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Gene: C5orf38 |
Gene summary for C5ORF38 |
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Gene information | Species | Human | Gene symbol | C5orf38 | Gene ID | 153571 |
Gene name | chromosome 5 open reading frame 38 | |
Gene Alias | CEI | |
Cytomap | 5p15.33 | |
Gene Type | ncRNA | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153571 | C5orf38 | P39T-E | Human | Esophagus | ESCC | 2.62e-04 | 1.03e-01 | 0.0894 |
153571 | C5orf38 | P40T-E | Human | Esophagus | ESCC | 7.57e-03 | 9.57e-02 | 0.109 |
153571 | C5orf38 | P42T-E | Human | Esophagus | ESCC | 3.70e-07 | 2.25e-01 | 0.1175 |
153571 | C5orf38 | P44T-E | Human | Esophagus | ESCC | 8.45e-04 | 1.99e-01 | 0.1096 |
153571 | C5orf38 | P47T-E | Human | Esophagus | ESCC | 3.74e-14 | 2.43e-01 | 0.1067 |
153571 | C5orf38 | P48T-E | Human | Esophagus | ESCC | 1.00e-09 | 1.53e-01 | 0.0959 |
153571 | C5orf38 | P49T-E | Human | Esophagus | ESCC | 1.92e-04 | 4.93e-01 | 0.1768 |
153571 | C5orf38 | P52T-E | Human | Esophagus | ESCC | 5.53e-13 | 3.34e-01 | 0.1555 |
153571 | C5orf38 | P54T-E | Human | Esophagus | ESCC | 1.78e-06 | 1.66e-01 | 0.0975 |
153571 | C5orf38 | P56T-E | Human | Esophagus | ESCC | 2.09e-16 | 1.65e+00 | 0.1613 |
153571 | C5orf38 | P57T-E | Human | Esophagus | ESCC | 2.42e-13 | 2.49e-01 | 0.0926 |
153571 | C5orf38 | P61T-E | Human | Esophagus | ESCC | 1.44e-13 | 2.71e-01 | 0.099 |
153571 | C5orf38 | P62T-E | Human | Esophagus | ESCC | 7.51e-12 | 1.96e-01 | 0.1302 |
153571 | C5orf38 | P65T-E | Human | Esophagus | ESCC | 1.05e-24 | 5.53e-01 | 0.0978 |
153571 | C5orf38 | P74T-E | Human | Esophagus | ESCC | 7.23e-07 | 2.79e-01 | 0.1479 |
153571 | C5orf38 | P75T-E | Human | Esophagus | ESCC | 8.79e-03 | 5.60e-02 | 0.1125 |
153571 | C5orf38 | P76T-E | Human | Esophagus | ESCC | 9.34e-09 | 2.38e-01 | 0.1207 |
153571 | C5orf38 | P79T-E | Human | Esophagus | ESCC | 9.88e-14 | 2.56e-01 | 0.1154 |
153571 | C5orf38 | P80T-E | Human | Esophagus | ESCC | 5.07e-09 | 1.72e-01 | 0.155 |
153571 | C5orf38 | P82T-E | Human | Esophagus | ESCC | 2.24e-04 | 3.62e-01 | 0.1072 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C5orf38 | SNV | Missense_Mutation | novel | c.56N>T | p.Ser19Phe | p.S19F | Q86SI9 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.937) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C5orf38 | SNV | Missense_Mutation | rs779809202 | c.410N>T | p.Arg137Ile | p.R137I | Q86SI9 | protein_coding | deleterious_low_confidence(0) | benign(0.027) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C5orf38 | SNV | Missense_Mutation | c.169N>A | p.Pro57Thr | p.P57T | Q86SI9 | protein_coding | deleterious_low_confidence(0) | benign(0.393) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C5orf38 | SNV | Missense_Mutation | novel | c.359N>T | p.Ala120Val | p.A120V | Q86SI9 | protein_coding | deleterious_low_confidence(0) | benign(0.441) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C5orf38 | SNV | Missense_Mutation | c.59N>T | p.Thr20Met | p.T20M | Q86SI9 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.96) | TCGA-DC-6155-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD | |
C5orf38 | SNV | Missense_Mutation | c.179N>A | p.Arg60Gln | p.R60Q | Q86SI9 | protein_coding | deleterious_low_confidence(0) | benign(0.367) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
C5orf38 | SNV | Missense_Mutation | c.205N>A | p.Val69Met | p.V69M | Q86SI9 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.596) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C5orf38 | SNV | Missense_Mutation | rs779809202 | c.410G>T | p.Arg137Ile | p.R137I | Q86SI9 | protein_coding | deleterious_low_confidence(0) | benign(0.027) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C5orf38 | SNV | Missense_Mutation | c.179N>A | p.Arg60Gln | p.R60Q | Q86SI9 | protein_coding | deleterious_low_confidence(0) | benign(0.367) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C5orf38 | SNV | Missense_Mutation | novel | c.289G>A | p.Gly97Arg | p.G97R | Q86SI9 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.978) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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