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Gene: C21orf59 |
Gene summary for C21ORF59 |
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Gene information | Species | Human | Gene symbol | C21orf59 | Gene ID | 56683 |
Gene name | cilia and flagella associated protein 298 | |
Gene Alias | C21orf48 | |
Cytomap | 21q22.11 | |
Gene Type | protein-coding | GO ID | GO:0003341 | UniProtAcc | P57076 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56683 | C21orf59 | P54T-E | Human | Esophagus | ESCC | 6.33e-27 | 5.76e-01 | 0.0975 |
56683 | C21orf59 | P56T-E | Human | Esophagus | ESCC | 1.89e-03 | 8.22e-01 | 0.1613 |
56683 | C21orf59 | P57T-E | Human | Esophagus | ESCC | 2.45e-24 | 5.49e-01 | 0.0926 |
56683 | C21orf59 | P61T-E | Human | Esophagus | ESCC | 1.31e-34 | 9.53e-01 | 0.099 |
56683 | C21orf59 | P62T-E | Human | Esophagus | ESCC | 8.88e-59 | 1.04e+00 | 0.1302 |
56683 | C21orf59 | P65T-E | Human | Esophagus | ESCC | 2.71e-26 | 5.36e-01 | 0.0978 |
56683 | C21orf59 | P74T-E | Human | Esophagus | ESCC | 1.13e-60 | 1.85e+00 | 0.1479 |
56683 | C21orf59 | P75T-E | Human | Esophagus | ESCC | 5.95e-31 | 8.99e-01 | 0.1125 |
56683 | C21orf59 | P76T-E | Human | Esophagus | ESCC | 5.28e-26 | 6.43e-01 | 0.1207 |
56683 | C21orf59 | P79T-E | Human | Esophagus | ESCC | 1.46e-17 | 5.50e-01 | 0.1154 |
56683 | C21orf59 | P80T-E | Human | Esophagus | ESCC | 3.27e-65 | 2.11e+00 | 0.155 |
56683 | C21orf59 | P82T-E | Human | Esophagus | ESCC | 1.73e-16 | 8.82e-01 | 0.1072 |
56683 | C21orf59 | P83T-E | Human | Esophagus | ESCC | 2.50e-34 | 1.02e+00 | 0.1738 |
56683 | C21orf59 | P84T-E | Human | Esophagus | ESCC | 7.79e-06 | 4.34e-01 | 0.0933 |
56683 | C21orf59 | P89T-E | Human | Esophagus | ESCC | 3.05e-19 | 1.13e+00 | 0.1752 |
56683 | C21orf59 | P91T-E | Human | Esophagus | ESCC | 4.69e-11 | 1.15e+00 | 0.1828 |
56683 | C21orf59 | P107T-E | Human | Esophagus | ESCC | 1.47e-25 | 5.86e-01 | 0.171 |
56683 | C21orf59 | P126T-E | Human | Esophagus | ESCC | 7.77e-10 | 8.68e-01 | 0.1125 |
56683 | C21orf59 | P127T-E | Human | Esophagus | ESCC | 2.05e-22 | 3.17e-01 | 0.0826 |
56683 | C21orf59 | P128T-E | Human | Esophagus | ESCC | 3.36e-63 | 2.09e+00 | 0.1241 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C21orf59 | SNV | Missense_Mutation | novel | c.689N>A | p.Arg230Gln | p.R230Q | P57076 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C21orf59 | SNV | Missense_Mutation | c.31G>C | p.Glu11Gln | p.E11Q | P57076 | protein_coding | tolerated(0.2) | benign(0.287) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
C21orf59 | SNV | Missense_Mutation | novel | c.125N>G | p.Gln42Arg | p.Q42R | P57076 | protein_coding | tolerated(0.47) | benign(0.013) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C21orf59 | SNV | Missense_Mutation | c.588G>T | p.Lys196Asn | p.K196N | P57076 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C21orf59 | SNV | Missense_Mutation | rs878855068 | c.250N>A | p.Val84Ile | p.V84I | P57076 | protein_coding | tolerated(1) | benign(0) | TCGA-CM-4744-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
C21orf59 | deletion | Frame_Shift_Del | c.246delN | p.Lys82AsnfsTer27 | p.K82Nfs*27 | P57076 | protein_coding | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |||
C21orf59 | SNV | Missense_Mutation | novel | c.668N>T | p.Arg223Met | p.R223M | P57076 | protein_coding | deleterious(0.01) | possibly_damaging(0.682) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C21orf59 | SNV | Missense_Mutation | novel | c.172N>A | p.Leu58Ile | p.L58I | P57076 | protein_coding | tolerated(0.08) | possibly_damaging(0.521) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C21orf59 | SNV | Missense_Mutation | novel | c.782A>G | p.Asp261Gly | p.D261G | P57076 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C21orf59 | SNV | Missense_Mutation | rs761867633 | c.494G>A | p.Arg165His | p.R165H | P57076 | protein_coding | deleterious(0.04) | probably_damaging(0.932) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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