![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C1orf174 |
Gene summary for C1ORF174 |
![]() |
Gene information | Species | Human | Gene symbol | C1orf174 | Gene ID | 339448 |
Gene name | chromosome 1 open reading frame 174 | |
Gene Alias | C1orf174 | |
Cytomap | 1p36.32 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8IYL3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339448 | C1orf174 | P49T-E | Human | Esophagus | ESCC | 2.48e-15 | 1.19e+00 | 0.1768 |
339448 | C1orf174 | P52T-E | Human | Esophagus | ESCC | 2.52e-25 | 5.40e-01 | 0.1555 |
339448 | C1orf174 | P54T-E | Human | Esophagus | ESCC | 1.73e-13 | 3.44e-01 | 0.0975 |
339448 | C1orf174 | P56T-E | Human | Esophagus | ESCC | 1.89e-09 | 8.04e-01 | 0.1613 |
339448 | C1orf174 | P57T-E | Human | Esophagus | ESCC | 1.11e-12 | 1.84e-01 | 0.0926 |
339448 | C1orf174 | P61T-E | Human | Esophagus | ESCC | 1.21e-10 | 2.56e-01 | 0.099 |
339448 | C1orf174 | P62T-E | Human | Esophagus | ESCC | 1.73e-47 | 8.03e-01 | 0.1302 |
339448 | C1orf174 | P65T-E | Human | Esophagus | ESCC | 8.85e-19 | 3.43e-01 | 0.0978 |
339448 | C1orf174 | P74T-E | Human | Esophagus | ESCC | 2.35e-25 | 6.65e-01 | 0.1479 |
339448 | C1orf174 | P75T-E | Human | Esophagus | ESCC | 1.44e-45 | 7.99e-01 | 0.1125 |
339448 | C1orf174 | P76T-E | Human | Esophagus | ESCC | 1.49e-30 | 4.97e-01 | 0.1207 |
339448 | C1orf174 | P79T-E | Human | Esophagus | ESCC | 8.65e-31 | 4.53e-01 | 0.1154 |
339448 | C1orf174 | P80T-E | Human | Esophagus | ESCC | 2.08e-61 | 1.82e+00 | 0.155 |
339448 | C1orf174 | P82T-E | Human | Esophagus | ESCC | 6.72e-15 | 6.90e-01 | 0.1072 |
339448 | C1orf174 | P83T-E | Human | Esophagus | ESCC | 4.21e-32 | 7.75e-01 | 0.1738 |
339448 | C1orf174 | P84T-E | Human | Esophagus | ESCC | 9.94e-08 | 4.18e-01 | 0.0933 |
339448 | C1orf174 | P89T-E | Human | Esophagus | ESCC | 1.67e-09 | 7.17e-01 | 0.1752 |
339448 | C1orf174 | P91T-E | Human | Esophagus | ESCC | 2.81e-13 | 9.44e-01 | 0.1828 |
339448 | C1orf174 | P107T-E | Human | Esophagus | ESCC | 3.79e-38 | 9.87e-01 | 0.171 |
339448 | C1orf174 | P126T-E | Human | Esophagus | ESCC | 5.56e-03 | 3.69e-01 | 0.1125 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf174 | SNV | Missense_Mutation | c.607N>C | p.Glu203Gln | p.E203Q | Q8IYL3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
C1orf174 | SNV | Missense_Mutation | rs367965839 | c.547N>A | p.Val183Ile | p.V183I | Q8IYL3 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-GM-A3NY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
C1orf174 | insertion | Frame_Shift_Ins | novel | c.455_456insCA | p.Glu152AspfsTer35 | p.E152Dfs*35 | Q8IYL3 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
C1orf174 | insertion | Frame_Shift_Ins | novel | c.453_454insAAATGCATTTCAGAGCCAAAGATGATGATGATGAC | p.Glu152LysfsTer46 | p.E152Kfs*46 | Q8IYL3 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
C1orf174 | SNV | Missense_Mutation | rs140673232 | c.319G>A | p.Glu107Lys | p.E107K | Q8IYL3 | protein_coding | tolerated(0.68) | benign(0.013) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf174 | SNV | Missense_Mutation | rs149232221 | c.241G>A | p.Ala81Thr | p.A81T | Q8IYL3 | protein_coding | tolerated(0.28) | benign(0.072) | TCGA-ZJ-AAXF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf174 | SNV | Missense_Mutation | novel | c.283N>A | p.Glu95Lys | p.E95K | Q8IYL3 | protein_coding | tolerated(0.15) | benign(0.038) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf174 | SNV | Missense_Mutation | c.594N>A | p.Phe198Leu | p.F198L | Q8IYL3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
C1orf174 | SNV | Missense_Mutation | novel | c.350N>T | p.Ala117Val | p.A117V | Q8IYL3 | protein_coding | tolerated(0.17) | benign(0.359) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf174 | SNV | Missense_Mutation | rs751234275 | c.437N>T | p.Ala146Val | p.A146V | Q8IYL3 | protein_coding | tolerated(0.21) | benign(0.344) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |