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Gene: C19orf24 |
Gene summary for C19ORF24 |
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Gene information | Species | Human | Gene symbol | C19orf24 | Gene ID | 55009 |
Gene name | family with sequence similarity 174 member C | |
Gene Alias | C19orf24 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BVV8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55009 | C19orf24 | P65T-E | Human | Esophagus | ESCC | 3.40e-14 | 4.05e-01 | 0.0978 |
55009 | C19orf24 | P74T-E | Human | Esophagus | ESCC | 9.93e-42 | 1.19e+00 | 0.1479 |
55009 | C19orf24 | P75T-E | Human | Esophagus | ESCC | 1.27e-90 | 1.93e+00 | 0.1125 |
55009 | C19orf24 | P76T-E | Human | Esophagus | ESCC | 6.89e-46 | 9.85e-01 | 0.1207 |
55009 | C19orf24 | P79T-E | Human | Esophagus | ESCC | 4.36e-18 | 4.20e-01 | 0.1154 |
55009 | C19orf24 | P80T-E | Human | Esophagus | ESCC | 8.59e-61 | 1.78e+00 | 0.155 |
55009 | C19orf24 | P82T-E | Human | Esophagus | ESCC | 6.46e-24 | 1.25e+00 | 0.1072 |
55009 | C19orf24 | P83T-E | Human | Esophagus | ESCC | 9.98e-65 | 1.73e+00 | 0.1738 |
55009 | C19orf24 | P84T-E | Human | Esophagus | ESCC | 7.59e-07 | 6.50e-01 | 0.0933 |
55009 | C19orf24 | P89T-E | Human | Esophagus | ESCC | 1.07e-32 | 2.17e+00 | 0.1752 |
55009 | C19orf24 | P91T-E | Human | Esophagus | ESCC | 2.58e-20 | 1.92e+00 | 0.1828 |
55009 | C19orf24 | P107T-E | Human | Esophagus | ESCC | 1.14e-74 | 1.83e+00 | 0.171 |
55009 | C19orf24 | P126T-E | Human | Esophagus | ESCC | 1.82e-10 | 1.41e+00 | 0.1125 |
55009 | C19orf24 | P127T-E | Human | Esophagus | ESCC | 1.29e-27 | 3.99e-01 | 0.0826 |
55009 | C19orf24 | P128T-E | Human | Esophagus | ESCC | 1.11e-53 | 2.15e+00 | 0.1241 |
55009 | C19orf24 | P130T-E | Human | Esophagus | ESCC | 1.25e-89 | 1.88e+00 | 0.1676 |
55009 | C19orf24 | S43 | Human | Liver | Cirrhotic | 4.06e-02 | -1.63e-01 | -0.0187 |
55009 | C19orf24 | HCC1_Meng | Human | Liver | HCC | 3.21e-71 | 1.23e-01 | 0.0246 |
55009 | C19orf24 | HCC2_Meng | Human | Liver | HCC | 3.76e-29 | 1.63e-01 | 0.0107 |
55009 | C19orf24 | cirrhotic1 | Human | Liver | Cirrhotic | 8.12e-10 | 2.08e-01 | 0.0202 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C19orf24 | SNV | Missense_Mutation | c.185C>A | p.Pro62Gln | p.P62Q | Q9BVV8 | protein_coding | tolerated(0.11) | possibly_damaging(0.574) | TCGA-4N-A93T-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | SD | |
C19orf24 | deletion | In_Frame_Del | rs761097595 | c.219_221delNNN | p.Phe74del | p.F74del | Q9BVV8 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
C19orf24 | SNV | Missense_Mutation | novel | c.305N>A | p.Arg102Gln | p.R102Q | Q9BVV8 | protein_coding | deleterious(0.01) | benign(0.416) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C19orf24 | SNV | Missense_Mutation | novel | c.361N>A | p.Asp121Asn | p.D121N | Q9BVV8 | protein_coding | deleterious(0.04) | benign(0.2) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
C19orf24 | deletion | In_Frame_Del | novel | c.244_246delGGC | p.Gly82del | p.G82del | Q9BVV8 | protein_coding | TCGA-G3-A3CK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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