Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: C17orf89

Gene summary for C17ORF89

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

C17orf89

Gene ID

284184

Gene nameNADH:ubiquinone oxidoreductase complex assembly factor 8
Gene AliasC17orf89
Cytomap17q25.3
Gene Typeprotein-coding
GO ID

GO:0006996

UniProtAcc

A1L188


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
284184C17orf89P65T-EHumanEsophagusESCC2.12e-377.68e-010.0978
284184C17orf89P74T-EHumanEsophagusESCC2.68e-591.87e+000.1479
284184C17orf89P75T-EHumanEsophagusESCC5.21e-441.03e+000.1125
284184C17orf89P76T-EHumanEsophagusESCC2.90e-591.35e+000.1207
284184C17orf89P79T-EHumanEsophagusESCC4.74e-431.01e+000.1154
284184C17orf89P80T-EHumanEsophagusESCC1.58e-632.12e+000.155
284184C17orf89P82T-EHumanEsophagusESCC3.36e-171.09e+000.1072
284184C17orf89P83T-EHumanEsophagusESCC1.44e-722.69e+000.1738
284184C17orf89P84T-EHumanEsophagusESCC1.84e-065.53e-010.0933
284184C17orf89P89T-EHumanEsophagusESCC2.66e-292.18e+000.1752
284184C17orf89P91T-EHumanEsophagusESCC8.66e-222.76e+000.1828
284184C17orf89P94T-EHumanEsophagusESCC1.43e-028.33e-010.0879
284184C17orf89P104T-EHumanEsophagusESCC2.25e-038.10e-010.0931
284184C17orf89P107T-EHumanEsophagusESCC3.40e-912.48e+000.171
284184C17orf89P126T-EHumanEsophagusESCC8.31e-081.12e+000.1125
284184C17orf89P127T-EHumanEsophagusESCC3.64e-202.68e-010.0826
284184C17orf89P128T-EHumanEsophagusESCC5.30e-732.56e+000.1241
284184C17orf89P130T-EHumanEsophagusESCC1.20e-962.04e+000.1676
284184C17orf89S43HumanLiverCirrhotic2.32e-08-2.82e-01-0.0187
284184C17orf89HCC1_MengHumanLiverHCC5.29e-794.79e-010.0246
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0471418BreastPrecancerThermogenesis68/684232/84654.40e-221.26e-209.69e-2168
hsa0471419BreastPrecancerThermogenesis68/684232/84654.40e-221.26e-209.69e-2168
hsa0471424BreastIDCThermogenesis75/867232/84658.41e-213.04e-192.27e-1975
hsa0471434BreastIDCThermogenesis75/867232/84658.41e-213.04e-192.27e-1975
hsa0471443BreastDCISThermogenesis74/846232/84658.72e-213.13e-192.30e-1974
hsa0471453BreastDCISThermogenesis74/846232/84658.72e-213.13e-192.30e-1974
hsa0471439EsophagusHGINThermogenesis91/1383232/84651.97e-175.36e-164.25e-1691
hsa04714114EsophagusHGINThermogenesis91/1383232/84651.97e-175.36e-164.25e-1691
hsa04714211EsophagusESCCThermogenesis163/4205232/84659.22e-111.14e-095.86e-10163
hsa04714310EsophagusESCCThermogenesis163/4205232/84659.22e-111.14e-095.86e-10163
hsa0471422LiverHCCThermogenesis170/4020232/84655.36e-162.25e-141.25e-14170
hsa0471432LiverHCCThermogenesis170/4020232/84655.36e-162.25e-141.25e-14170
hsa0471412StomachGCThermogenesis56/708232/84651.35e-134.32e-123.04e-1256
hsa0471413StomachGCThermogenesis56/708232/84651.35e-134.32e-123.04e-1256
hsa0471421StomachCAG with IMThermogenesis55/640232/84657.01e-152.23e-131.56e-1355
hsa0471431StomachCAG with IMThermogenesis55/640232/84657.01e-152.23e-131.56e-1355
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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