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Gene: BORCS7 |
Gene summary for BORCS7 |
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Gene information | Species | Human | Gene symbol | BORCS7 | Gene ID | 119032 |
Gene name | BLOC-1 related complex subunit 7 | |
Gene Alias | C10orf32 | |
Cytomap | 10q24.32 | |
Gene Type | protein-coding | GO ID | GO:0000323 | UniProtAcc | A0A0B4J1R7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
119032 | BORCS7 | P52T-E | Human | Esophagus | ESCC | 1.19e-13 | 3.91e-02 | 0.1555 |
119032 | BORCS7 | P54T-E | Human | Esophagus | ESCC | 1.31e-14 | 1.48e-01 | 0.0975 |
119032 | BORCS7 | P56T-E | Human | Esophagus | ESCC | 3.82e-09 | 9.71e-01 | 0.1613 |
119032 | BORCS7 | P57T-E | Human | Esophagus | ESCC | 1.08e-22 | 1.99e-01 | 0.0926 |
119032 | BORCS7 | P61T-E | Human | Esophagus | ESCC | 5.83e-12 | 2.19e-01 | 0.099 |
119032 | BORCS7 | P62T-E | Human | Esophagus | ESCC | 4.81e-33 | 6.61e-01 | 0.1302 |
119032 | BORCS7 | P65T-E | Human | Esophagus | ESCC | 1.91e-14 | 2.59e-01 | 0.0978 |
119032 | BORCS7 | P74T-E | Human | Esophagus | ESCC | 1.32e-15 | 4.97e-01 | 0.1479 |
119032 | BORCS7 | P75T-E | Human | Esophagus | ESCC | 6.11e-25 | 5.00e-01 | 0.1125 |
119032 | BORCS7 | P76T-E | Human | Esophagus | ESCC | 3.18e-18 | 2.65e-01 | 0.1207 |
119032 | BORCS7 | P79T-E | Human | Esophagus | ESCC | 3.38e-20 | 2.96e-01 | 0.1154 |
119032 | BORCS7 | P80T-E | Human | Esophagus | ESCC | 7.95e-30 | 9.18e-01 | 0.155 |
119032 | BORCS7 | P82T-E | Human | Esophagus | ESCC | 2.77e-13 | 8.35e-01 | 0.1072 |
119032 | BORCS7 | P83T-E | Human | Esophagus | ESCC | 3.27e-09 | 2.15e-01 | 0.1738 |
119032 | BORCS7 | P89T-E | Human | Esophagus | ESCC | 6.73e-08 | 7.78e-01 | 0.1752 |
119032 | BORCS7 | P91T-E | Human | Esophagus | ESCC | 4.83e-05 | 9.18e-01 | 0.1828 |
119032 | BORCS7 | P107T-E | Human | Esophagus | ESCC | 5.99e-24 | 5.44e-01 | 0.171 |
119032 | BORCS7 | P127T-E | Human | Esophagus | ESCC | 4.00e-08 | 2.52e-02 | 0.0826 |
119032 | BORCS7 | P128T-E | Human | Esophagus | ESCC | 1.00e-10 | 1.89e-01 | 0.1241 |
119032 | BORCS7 | P130T-E | Human | Esophagus | ESCC | 3.97e-41 | 9.66e-01 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BORCS7 | SNV | Missense_Mutation | rs765943098 | c.65N>T | p.Thr22Met | p.T22M | Q96B45 | protein_coding | deleterious(0.03) | possibly_damaging(0.795) | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BORCS7 | insertion | In_Frame_Ins | novel | c.303_304insGCCCAGGCTGGTCTT | p.Leu101_Asn102insAlaGlnAlaGlyLeu | p.L101_N102insAQAGL | Q96B45 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
BORCS7 | insertion | Frame_Shift_Ins | novel | c.305_306insAC | p.Asn102LysfsTer5 | p.N102Kfs*5 | Q96B45 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
BORCS7 | SNV | Missense_Mutation | c.202N>T | p.Asp68Tyr | p.D68Y | Q96B45 | protein_coding | deleterious(0.02) | possibly_damaging(0.673) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
BORCS7 | SNV | Missense_Mutation | c.103N>T | p.Leu35Phe | p.L35F | Q96B45 | protein_coding | deleterious(0.03) | benign(0.315) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BORCS7 | SNV | Missense_Mutation | rs748603513 | c.227N>C | p.Ile76Thr | p.I76T | Q96B45 | protein_coding | tolerated(0.1) | benign(0.049) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
BORCS7 | SNV | Missense_Mutation | novel | c.161G>A | p.Arg54Gln | p.R54Q | Q96B45 | protein_coding | tolerated(0.07) | benign(0.177) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BORCS7 | SNV | Missense_Mutation | novel | c.294N>T | p.Gln98His | p.Q98H | Q96B45 | protein_coding | deleterious(0.02) | possibly_damaging(0.789) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BORCS7 | SNV | Missense_Mutation | novel | c.149N>A | p.Gly50Asp | p.G50D | Q96B45 | protein_coding | tolerated(0.13) | possibly_damaging(0.676) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BORCS7 | SNV | Missense_Mutation | novel | c.219G>T | p.Met73Ile | p.M73I | Q96B45 | protein_coding | tolerated(0.07) | possibly_damaging(0.465) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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