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Gene: BAMBI |
Gene summary for BAMBI |
Gene summary. |
Gene information | Species | Human | Gene symbol | BAMBI | Gene ID | 25805 |
Gene name | BMP and activin membrane bound inhibitor | |
Gene Alias | NMA | |
Cytomap | 10p12.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q13145 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25805 | BAMBI | P65T-E | Human | Esophagus | ESCC | 6.23e-44 | 1.18e+00 | 0.0978 |
25805 | BAMBI | P74T-E | Human | Esophagus | ESCC | 2.80e-10 | 6.35e-01 | 0.1479 |
25805 | BAMBI | P75T-E | Human | Esophagus | ESCC | 3.85e-18 | 5.77e-01 | 0.1125 |
25805 | BAMBI | P76T-E | Human | Esophagus | ESCC | 1.47e-32 | 9.58e-01 | 0.1207 |
25805 | BAMBI | P79T-E | Human | Esophagus | ESCC | 8.35e-29 | 7.22e-01 | 0.1154 |
25805 | BAMBI | P82T-E | Human | Esophagus | ESCC | 2.92e-06 | 4.75e-01 | 0.1072 |
25805 | BAMBI | P83T-E | Human | Esophagus | ESCC | 3.12e-10 | 3.62e-01 | 0.1738 |
25805 | BAMBI | P84T-E | Human | Esophagus | ESCC | 5.18e-07 | 4.95e-01 | 0.0933 |
25805 | BAMBI | P107T-E | Human | Esophagus | ESCC | 6.53e-21 | 8.24e-01 | 0.171 |
25805 | BAMBI | P126T-E | Human | Esophagus | ESCC | 4.53e-06 | 1.68e+00 | 0.1125 |
25805 | BAMBI | P127T-E | Human | Esophagus | ESCC | 4.34e-11 | 4.77e-01 | 0.0826 |
25805 | BAMBI | P128T-E | Human | Esophagus | ESCC | 1.24e-44 | 2.83e+00 | 0.1241 |
25805 | BAMBI | P130T-E | Human | Esophagus | ESCC | 2.77e-07 | 3.84e-01 | 0.1676 |
25805 | BAMBI | S43 | Human | Liver | Cirrhotic | 9.09e-08 | -1.56e-01 | -0.0187 |
25805 | BAMBI | HCC1_Meng | Human | Liver | HCC | 1.98e-75 | -1.07e-01 | 0.0246 |
25805 | BAMBI | HCC2_Meng | Human | Liver | HCC | 1.95e-11 | -1.98e-01 | 0.0107 |
25805 | BAMBI | cirrhotic1 | Human | Liver | Cirrhotic | 1.63e-08 | 2.79e-01 | 0.0202 |
25805 | BAMBI | cirrhotic2 | Human | Liver | Cirrhotic | 6.84e-12 | 2.14e-01 | 0.0201 |
25805 | BAMBI | cirrhotic3 | Human | Liver | Cirrhotic | 4.09e-03 | 7.61e-02 | 0.0215 |
25805 | BAMBI | HCC1 | Human | Liver | HCC | 4.51e-06 | 4.70e+00 | 0.5336 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005109825 | Esophagus | HGIN | regulation of binding | 78/2587 | 363/18723 | 3.73e-05 | 9.30e-04 | 78 |
GO:005109925 | Esophagus | HGIN | positive regulation of binding | 42/2587 | 173/18723 | 1.51e-04 | 2.97e-03 | 42 |
GO:000164917 | Esophagus | HGIN | osteoblast differentiation | 50/2587 | 229/18723 | 5.88e-04 | 8.30e-03 | 50 |
GO:003011116 | Esophagus | HGIN | regulation of Wnt signaling pathway | 65/2587 | 328/18723 | 1.53e-03 | 1.77e-02 | 65 |
GO:009026310 | Esophagus | HGIN | positive regulation of canonical Wnt signaling pathway | 26/2587 | 106/18723 | 2.17e-03 | 2.25e-02 | 26 |
GO:001605516 | Esophagus | HGIN | Wnt signaling pathway | 83/2587 | 444/18723 | 2.27e-03 | 2.33e-02 | 83 |
GO:019873816 | Esophagus | HGIN | cell-cell signaling by wnt | 83/2587 | 446/18723 | 2.58e-03 | 2.55e-02 | 83 |
GO:003017710 | Esophagus | HGIN | positive regulation of Wnt signaling pathway | 31/2587 | 140/18723 | 4.77e-03 | 4.09e-02 | 31 |
GO:006082816 | Esophagus | HGIN | regulation of canonical Wnt signaling pathway | 50/2587 | 253/18723 | 5.27e-03 | 4.35e-02 | 50 |
GO:000150316 | Esophagus | HGIN | ossification | 75/2587 | 408/18723 | 5.49e-03 | 4.49e-02 | 75 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:0051099111 | Esophagus | ESCC | positive regulation of binding | 122/8552 | 173/18723 | 2.79e-11 | 9.45e-10 | 122 |
GO:004339320 | Esophagus | ESCC | regulation of protein binding | 135/8552 | 196/18723 | 3.69e-11 | 1.22e-09 | 135 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:00715599 | Esophagus | ESCC | response to transforming growth factor beta | 157/8552 | 256/18723 | 2.95e-07 | 4.23e-06 | 157 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:006082817 | Esophagus | ESCC | regulation of canonical Wnt signaling pathway | 153/8552 | 253/18723 | 1.38e-06 | 1.67e-05 | 153 |
GO:000164918 | Esophagus | ESCC | osteoblast differentiation | 140/8552 | 229/18723 | 1.63e-06 | 1.95e-05 | 140 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa043506 | Oral cavity | OSCC | TGF-beta signaling pathway | 60/3704 | 108/8465 | 8.66e-03 | 1.97e-02 | 1.00e-02 | 60 |
hsa0435013 | Oral cavity | OSCC | TGF-beta signaling pathway | 60/3704 | 108/8465 | 8.66e-03 | 1.97e-02 | 1.00e-02 | 60 |
hsa0435041 | Oral cavity | NEOLP | TGF-beta signaling pathway | 28/1112 | 108/8465 | 2.46e-04 | 1.62e-03 | 1.02e-03 | 28 |
hsa0431024 | Oral cavity | NEOLP | Wnt signaling pathway | 34/1112 | 171/8465 | 8.05e-03 | 2.88e-02 | 1.81e-02 | 34 |
hsa0435051 | Oral cavity | NEOLP | TGF-beta signaling pathway | 28/1112 | 108/8465 | 2.46e-04 | 1.62e-03 | 1.02e-03 | 28 |
hsa0431034 | Oral cavity | NEOLP | Wnt signaling pathway | 34/1112 | 171/8465 | 8.05e-03 | 2.88e-02 | 1.81e-02 | 34 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BAMBI | SNV | Missense_Mutation | c.103G>T | p.Ala35Ser | p.A35S | Q13145 | protein_coding | tolerated(0.13) | benign(0.258) | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
BAMBI | insertion | Frame_Shift_Ins | novel | c.534_535insCA | p.Glu179GlnfsTer34 | p.E179Qfs*34 | Q13145 | protein_coding | TCGA-A2-A0T2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | ||
BAMBI | insertion | Nonsense_Mutation | novel | c.535_536insCCTGGCTAACATGGTGAAACCCCATCTCTACTACAAATACA | p.Glu179AlafsTer6 | p.E179Afs*6 | Q13145 | protein_coding | TCGA-A2-A0T2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | ||
BAMBI | SNV | Missense_Mutation | novel | c.521G>T | p.Arg174Met | p.R174M | Q13145 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAMBI | SNV | Missense_Mutation | novel | c.669N>T | p.Glu223Asp | p.E223D | Q13145 | protein_coding | tolerated_low_confidence(0.15) | probably_damaging(0.978) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BAMBI | SNV | Missense_Mutation | rs372503225 | c.148G>T | p.Ala50Ser | p.A50S | Q13145 | protein_coding | tolerated(0.13) | probably_damaging(0.999) | TCGA-AA-A024-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BAMBI | SNV | Missense_Mutation | rs375455762 | c.166C>A | p.Leu56Ile | p.L56I | Q13145 | protein_coding | tolerated(0.08) | probably_damaging(0.998) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BAMBI | SNV | Missense_Mutation | rs776749607 | c.458C>T | p.Ala153Val | p.A153V | Q13145 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BAMBI | SNV | Missense_Mutation | rs369743386 | c.530G>A | p.Arg177Gln | p.R177Q | Q13145 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BAMBI | SNV | Missense_Mutation | c.113T>C | p.Val38Ala | p.V38A | Q13145 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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