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Gene: AVPI1 |
Gene summary for AVPI1 |
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Gene information | Species | Human | Gene symbol | AVPI1 | Gene ID | 60370 |
Gene name | arginine vasopressin induced 1 | |
Gene Alias | PP5395 | |
Cytomap | 10q24.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q5T686 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60370 | AVPI1 | P54T-E | Human | Esophagus | ESCC | 5.44e-21 | 9.22e-01 | 0.0975 |
60370 | AVPI1 | P56T-E | Human | Esophagus | ESCC | 6.49e-05 | 1.41e+00 | 0.1613 |
60370 | AVPI1 | P57T-E | Human | Esophagus | ESCC | 3.76e-08 | 5.75e-01 | 0.0926 |
60370 | AVPI1 | P61T-E | Human | Esophagus | ESCC | 2.24e-07 | 2.19e-01 | 0.099 |
60370 | AVPI1 | P62T-E | Human | Esophagus | ESCC | 1.04e-35 | 1.10e+00 | 0.1302 |
60370 | AVPI1 | P65T-E | Human | Esophagus | ESCC | 1.13e-09 | 4.48e-01 | 0.0978 |
60370 | AVPI1 | P74T-E | Human | Esophagus | ESCC | 3.75e-26 | 1.64e+00 | 0.1479 |
60370 | AVPI1 | P75T-E | Human | Esophagus | ESCC | 1.83e-22 | 1.09e+00 | 0.1125 |
60370 | AVPI1 | P76T-E | Human | Esophagus | ESCC | 4.46e-16 | 6.10e-01 | 0.1207 |
60370 | AVPI1 | P79T-E | Human | Esophagus | ESCC | 1.09e-04 | 2.53e-01 | 0.1154 |
60370 | AVPI1 | P80T-E | Human | Esophagus | ESCC | 1.06e-35 | 1.32e+00 | 0.155 |
60370 | AVPI1 | P82T-E | Human | Esophagus | ESCC | 2.03e-12 | 7.67e-01 | 0.1072 |
60370 | AVPI1 | P83T-E | Human | Esophagus | ESCC | 2.36e-21 | 1.11e+00 | 0.1738 |
60370 | AVPI1 | P84T-E | Human | Esophagus | ESCC | 1.50e-02 | 3.72e-01 | 0.0933 |
60370 | AVPI1 | P89T-E | Human | Esophagus | ESCC | 5.99e-08 | 1.04e+00 | 0.1752 |
60370 | AVPI1 | P107T-E | Human | Esophagus | ESCC | 5.66e-27 | 1.03e+00 | 0.171 |
60370 | AVPI1 | P127T-E | Human | Esophagus | ESCC | 3.87e-09 | 1.66e-01 | 0.0826 |
60370 | AVPI1 | P128T-E | Human | Esophagus | ESCC | 2.21e-11 | 6.82e-01 | 0.1241 |
60370 | AVPI1 | P130T-E | Human | Esophagus | ESCC | 1.65e-59 | 1.63e+00 | 0.1676 |
60370 | AVPI1 | C04 | Human | Oral cavity | OSCC | 7.46e-26 | 1.70e+00 | 0.2633 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434104 | Cervix | CC | positive regulation of MAPK cascade | 90/2311 | 480/18723 | 2.92e-05 | 4.83e-04 | 90 |
GO:00434107 | Oral cavity | OSCC | positive regulation of MAPK cascade | 213/7305 | 480/18723 | 8.71e-03 | 3.16e-02 | 213 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AVPI1 | SNV | Missense_Mutation | rs150249445 | c.103G>A | p.Glu35Lys | p.E35K | Q5T686 | protein_coding | tolerated(0.2) | benign(0.242) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
AVPI1 | SNV | Missense_Mutation | c.437N>C | p.Arg146Thr | p.R146T | Q5T686 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
AVPI1 | SNV | Missense_Mutation | novel | c.328G>A | p.Ala110Thr | p.A110T | Q5T686 | protein_coding | tolerated(0.35) | benign(0.006) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AVPI1 | SNV | Missense_Mutation | c.38N>T | p.Pro13Leu | p.P13L | Q5T686 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-Q1-A73Q-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
AVPI1 | SNV | Missense_Mutation | rs770933514 | c.133N>T | p.Arg45Cys | p.R45C | Q5T686 | protein_coding | deleterious(0.04) | probably_damaging(0.966) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
AVPI1 | SNV | Missense_Mutation | rs554930916 | c.161N>A | p.Arg54Gln | p.R54Q | Q5T686 | protein_coding | deleterious(0.02) | possibly_damaging(0.889) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
AVPI1 | SNV | Missense_Mutation | rs544820695 | c.100N>A | p.Ala34Thr | p.A34T | Q5T686 | protein_coding | tolerated(0.12) | benign(0.011) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AVPI1 | SNV | Missense_Mutation | c.329N>T | p.Ala110Val | p.A110V | Q5T686 | protein_coding | tolerated(0.1) | benign(0.109) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
AVPI1 | insertion | Frame_Shift_Ins | novel | c.38_39insC | p.Trp14LeufsTer6 | p.W14Lfs*6 | Q5T686 | protein_coding | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
AVPI1 | SNV | Missense_Mutation | novel | c.184G>A | p.Ala62Thr | p.A62T | Q5T686 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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