![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ATP5J2 |
Gene summary for ATP5J2 |
![]() |
Gene information | Species | Human | Gene symbol | ATP5J2 | Gene ID | 9551 |
Gene name | ATP synthase membrane subunit f | |
Gene Alias | ATP5J2 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P56134 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9551 | ATP5J2 | M1 | Human | Breast | IDC | 7.12e-10 | -3.91e-01 | 0.1577 |
9551 | ATP5J2 | M2 | Human | Breast | IDC | 1.80e-02 | -3.91e-01 | 0.21 |
9551 | ATP5J2 | NCCBC11 | Human | Breast | DCIS | 1.18e-02 | -3.91e-01 | 0.1232 |
9551 | ATP5J2 | NCCBC14 | Human | Breast | DCIS | 9.01e-14 | -3.91e-01 | 0.2021 |
9551 | ATP5J2 | NCCBC3 | Human | Breast | DCIS | 1.87e-24 | -3.91e-01 | 0.1198 |
9551 | ATP5J2 | NCCBC5 | Human | Breast | DCIS | 1.84e-13 | -3.91e-01 | 0.2046 |
9551 | ATP5J2 | P1 | Human | Breast | IDC | 3.35e-14 | -3.91e-01 | 0.1527 |
9551 | ATP5J2 | P2 | Human | Breast | IDC | 1.37e-09 | -3.91e-01 | 0.21 |
9551 | ATP5J2 | DCIS2 | Human | Breast | DCIS | 5.81e-18 | -3.91e-01 | 0.0085 |
9551 | ATP5J2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.36e-60 | 1.12e+00 | 0.294 |
9551 | ATP5J2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.23e-14 | 1.17e+00 | 0.3487 |
9551 | ATP5J2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.31e-46 | 1.43e+00 | 0.281 |
9551 | ATP5J2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.05e-52 | 1.01e+00 | 0.3859 |
9551 | ATP5J2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.16e-32 | 8.80e-01 | 0.2585 |
9551 | ATP5J2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.37e-47 | 8.85e-01 | 0.3005 |
9551 | ATP5J2 | LZE4T | Human | Esophagus | ESCC | 3.32e-08 | -6.24e-01 | 0.0811 |
9551 | ATP5J2 | LZE7T | Human | Esophagus | ESCC | 1.26e-03 | -6.24e-01 | 0.0667 |
9551 | ATP5J2 | LZE8T | Human | Esophagus | ESCC | 2.66e-07 | -6.24e-01 | 0.067 |
9551 | ATP5J2 | LZE20T | Human | Esophagus | ESCC | 1.87e-07 | -6.24e-01 | 0.0662 |
9551 | ATP5J2 | LZE22D1 | Human | Esophagus | HGIN | 1.89e-03 | -6.24e-01 | 0.0595 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0019023 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0471424 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0019033 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0471434 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0019043 | Breast | DCIS | Oxidative phosphorylation | 61/846 | 134/8465 | 9.84e-27 | 5.30e-25 | 3.90e-25 | 61 |
hsa0471443 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0019053 | Breast | DCIS | Oxidative phosphorylation | 61/846 | 134/8465 | 9.84e-27 | 5.30e-25 | 3.90e-25 | 61 |
hsa0471453 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0019018 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0471420 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa0019019 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa04714110 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa00190 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa001901 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
Page: 1 2 3 4 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP5J2 | SNV | Missense_Mutation | c.275A>C | p.Lys92Thr | p.K92T | P56134 | protein_coding | deleterious(0) | possibly_damaging(0.649) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATP5J2 | SNV | Missense_Mutation | rs11545970 | c.128N>T | p.Ala43Val | p.A43V | P56134 | protein_coding | tolerated(0.06) | benign(0.358) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | novel | c.50A>C | p.Lys17Thr | p.K17T | P56134 | protein_coding | deleterious(0.02) | possibly_damaging(0.461) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | rs762526939 | c.265C>T | p.Arg89Trp | p.R89W | P56134 | protein_coding | tolerated(0.06) | benign(0.125) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | novel | c.17N>T | p.Glu6Val | p.E6V | P56134 | protein_coding | tolerated(0.25) | possibly_damaging(0.661) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | novel | c.22N>T | p.Pro8Ser | p.P8S | P56134 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-56-8622-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP5J2 | SNV | Missense_Mutation | rs771516671 | c.149N>A | p.Arg50Gln | p.R50Q | P56134 | protein_coding | tolerated(0.32) | benign(0.015) | TCGA-D7-6520-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | epirubicin | SD |
ATP5J2 | SNV | Missense_Mutation | rs761746638 | c.220N>A | p.Val74Met | p.V74M | P56134 | protein_coding | tolerated(0.15) | benign(0.184) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |