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Gene: ATP10D |
Gene summary for ATP10D |
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Gene information | Species | Human | Gene symbol | ATP10D | Gene ID | 57205 |
Gene name | ATPase phospholipid transporting 10D (putative) | |
Gene Alias | ATPVD | |
Cytomap | 4p12 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9P241 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57205 | ATP10D | P75T-E | Human | Esophagus | ESCC | 7.99e-20 | 3.73e-01 | 0.1125 |
57205 | ATP10D | P76T-E | Human | Esophagus | ESCC | 2.25e-03 | 9.58e-02 | 0.1207 |
57205 | ATP10D | P79T-E | Human | Esophagus | ESCC | 2.77e-03 | 4.09e-02 | 0.1154 |
57205 | ATP10D | P80T-E | Human | Esophagus | ESCC | 2.13e-21 | 5.91e-01 | 0.155 |
57205 | ATP10D | P83T-E | Human | Esophagus | ESCC | 6.19e-21 | 4.39e-01 | 0.1738 |
57205 | ATP10D | P89T-E | Human | Esophagus | ESCC | 4.73e-02 | 3.77e-01 | 0.1752 |
57205 | ATP10D | P91T-E | Human | Esophagus | ESCC | 4.47e-07 | 4.68e-01 | 0.1828 |
57205 | ATP10D | P107T-E | Human | Esophagus | ESCC | 1.17e-21 | 5.77e-01 | 0.171 |
57205 | ATP10D | P127T-E | Human | Esophagus | ESCC | 4.92e-05 | 8.68e-02 | 0.0826 |
57205 | ATP10D | P128T-E | Human | Esophagus | ESCC | 2.72e-05 | 1.33e-01 | 0.1241 |
57205 | ATP10D | P130T-E | Human | Esophagus | ESCC | 2.30e-10 | 1.41e-01 | 0.1676 |
57205 | ATP10D | C04 | Human | Oral cavity | OSCC | 6.20e-16 | 9.64e-01 | 0.2633 |
57205 | ATP10D | C21 | Human | Oral cavity | OSCC | 3.21e-20 | 7.86e-01 | 0.2678 |
57205 | ATP10D | C30 | Human | Oral cavity | OSCC | 2.20e-21 | 1.02e+00 | 0.3055 |
57205 | ATP10D | C43 | Human | Oral cavity | OSCC | 3.24e-04 | 1.20e-01 | 0.1704 |
57205 | ATP10D | C51 | Human | Oral cavity | OSCC | 1.61e-13 | 8.60e-01 | 0.2674 |
57205 | ATP10D | C06 | Human | Oral cavity | OSCC | 2.64e-03 | 1.01e+00 | 0.2699 |
57205 | ATP10D | EOLP-1 | Human | Oral cavity | EOLP | 1.43e-02 | 2.55e-01 | -0.0202 |
57205 | ATP10D | SYSMH1 | Human | Oral cavity | OSCC | 1.77e-04 | 1.51e-01 | 0.1127 |
57205 | ATP10D | SYSMH2 | Human | Oral cavity | OSCC | 1.09e-09 | 2.43e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00157483 | Oral cavity | EOLP | organophosphate ester transport | 28/2218 | 140/18723 | 3.66e-03 | 2.05e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP10D | SNV | Missense_Mutation | rs149296162 | c.2045N>A | p.Ser682Asn | p.S682N | Q9P241 | protein_coding | tolerated(0.27) | benign(0.014) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
ATP10D | SNV | Missense_Mutation | c.2279G>C | p.Gly760Ala | p.G760A | Q9P241 | protein_coding | deleterious(0.04) | possibly_damaging(0.899) | TCGA-A2-A25D-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
ATP10D | SNV | Missense_Mutation | c.3184A>G | p.Ser1062Gly | p.S1062G | Q9P241 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP10D | SNV | Missense_Mutation | novel | c.521N>T | p.Asp174Val | p.D174V | Q9P241 | protein_coding | deleterious(0) | possibly_damaging(0.824) | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ATP10D | SNV | Missense_Mutation | c.830N>C | p.Arg277Thr | p.R277T | Q9P241 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP10D | SNV | Missense_Mutation | c.736N>A | p.Glu246Lys | p.E246K | Q9P241 | protein_coding | deleterious(0.01) | probably_damaging(0.967) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ATP10D | SNV | Missense_Mutation | novel | c.544C>A | p.Arg182Ser | p.R182S | Q9P241 | protein_coding | deleterious(0) | possibly_damaging(0.527) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP10D | SNV | Missense_Mutation | novel | c.3178G>T | p.Asp1060Tyr | p.D1060Y | Q9P241 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP10D | SNV | Missense_Mutation | c.1234G>A | p.Glu412Lys | p.E412K | Q9P241 | protein_coding | tolerated(0.07) | benign(0.41) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP10D | SNV | Missense_Mutation | rs763021315 | c.4115N>A | p.Gly1372Glu | p.G1372E | Q9P241 | protein_coding | tolerated(1) | benign(0) | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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