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Gene: ARL14 |
Gene summary for ARL14 |
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Gene information | Species | Human | Gene symbol | ARL14 | Gene ID | 80117 |
Gene name | ADP ribosylation factor like GTPase 14 | |
Gene Alias | ARF7 | |
Cytomap | 3q25.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8N4G2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80117 | ARL14 | Pat13-B | Human | Stomach | GC | 5.19e-09 | -7.10e-01 | 0.0555 |
80117 | ARL14 | Pat15-B | Human | Stomach | GC | 2.08e-14 | -7.11e-01 | -0.0778 |
80117 | ARL14 | Pat16-B | Human | Stomach | GC | 2.44e-08 | -1.72e-01 | 0.1918 |
80117 | ARL14 | Pat17-B | Human | Stomach | GC | 1.50e-05 | -2.93e-01 | 0.3109 |
80117 | ARL14 | Pat18-B | Human | Stomach | GC | 1.01e-16 | -7.39e-01 | -0.0432 |
80117 | ARL14 | Pat19-B | Human | Stomach | GC | 7.72e-16 | -6.68e-01 | 0.0826 |
80117 | ARL14 | Pat22-B | Human | Stomach | GC | 8.30e-33 | -5.55e-01 | -0.1042 |
80117 | ARL14 | Pat24-B | Human | Stomach | GC | 1.49e-11 | -5.46e-01 | -0.1184 |
80117 | ARL14 | Pat25-A | Human | Stomach | CAG with IM | 7.38e-28 | -7.37e-01 | -0.1648 |
80117 | ARL14 | Pat26-A | Human | Stomach | CSG | 9.36e-32 | -7.88e-01 | -0.2402 |
80117 | ARL14 | Pat28-A | Human | Stomach | CSG | 2.03e-12 | -5.69e-01 | -0.2594 |
80117 | ARL14 | Pat29-A | Human | Stomach | CAG with IM | 4.33e-05 | -7.65e-01 | -0.2769 |
80117 | ARL14 | NAG_1 | Human | Stomach | CSG | 5.72e-17 | 7.16e-01 | -0.3534 |
80117 | ARL14 | NAG_2 | Human | Stomach | CSG | 3.01e-13 | 5.47e-01 | -0.3324 |
80117 | ARL14 | NAG_3 | Human | Stomach | CSG | 1.30e-03 | 4.50e-01 | -0.2816 |
80117 | ARL14 | CAG_2 | Human | Stomach | CAG | 7.03e-06 | -1.50e-01 | -0.2831 |
80117 | ARL14 | CAG_3 | Human | Stomach | CAG | 8.36e-09 | 1.74e-01 | -0.2766 |
80117 | ARL14 | SIM_1 | Human | Stomach | SIM | 1.09e-02 | 7.68e-02 | 0.3573 |
80117 | ARL14 | SIM_2 | Human | Stomach | SIM | 4.58e-06 | -8.98e-02 | 0.3139 |
80117 | ARL14 | EGC | Human | Stomach | GC | 1.29e-02 | -2.04e-01 | 0.1683 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARL14 | SNV | Missense_Mutation | rs772796463 | c.392N>C | p.Leu131Pro | p.L131P | Q8N4G2 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-A8-A08C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
ARL14 | SNV | Missense_Mutation | c.567N>G | p.Phe189Leu | p.F189L | Q8N4G2 | protein_coding | tolerated_low_confidence(0.06) | benign(0.005) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
ARL14 | SNV | Missense_Mutation | rs762555229 | c.229N>C | p.Cys77Arg | p.C77R | Q8N4G2 | protein_coding | deleterious(0.02) | benign(0.038) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARL14 | SNV | Missense_Mutation | c.210N>C | p.Lys70Asn | p.K70N | Q8N4G2 | protein_coding | deleterious(0.01) | benign(0.231) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARL14 | SNV | Missense_Mutation | c.133N>T | p.Ile45Leu | p.I45L | Q8N4G2 | protein_coding | deleterious(0.02) | benign(0.273) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARL14 | SNV | Missense_Mutation | c.355N>A | p.Val119Ile | p.V119I | Q8N4G2 | protein_coding | tolerated(0.19) | benign(0.044) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARL14 | SNV | Missense_Mutation | rs17853289 | c.172C>T | p.Leu58Phe | p.L58F | Q8N4G2 | protein_coding | tolerated(0.3) | benign(0.012) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ARL14 | SNV | Missense_Mutation | novel | c.117N>G | p.Ile39Met | p.I39M | Q8N4G2 | protein_coding | deleterious(0) | benign(0.185) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARL14 | SNV | Missense_Mutation | c.277N>T | p.Asp93Tyr | p.D93Y | Q8N4G2 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL14 | SNV | Missense_Mutation | rs754095868 | c.26C>T | p.Pro9Leu | p.P9L | Q8N4G2 | protein_coding | tolerated(0.75) | benign(0.001) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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