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Gene: ARIH2 |
Gene summary for ARIH2 |
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Gene information | Species | Human | Gene symbol | ARIH2 | Gene ID | 10425 |
Gene name | ariadne RBR E3 ubiquitin protein ligase 2 | |
Gene Alias | ARI2 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | O95376 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10425 | ARIH2 | P48T-E | Human | Esophagus | ESCC | 3.15e-19 | 2.31e-01 | 0.0959 |
10425 | ARIH2 | P49T-E | Human | Esophagus | ESCC | 1.23e-09 | 1.03e+00 | 0.1768 |
10425 | ARIH2 | P52T-E | Human | Esophagus | ESCC | 1.31e-17 | 5.00e-01 | 0.1555 |
10425 | ARIH2 | P54T-E | Human | Esophagus | ESCC | 5.02e-12 | 3.27e-01 | 0.0975 |
10425 | ARIH2 | P56T-E | Human | Esophagus | ESCC | 8.10e-08 | 9.69e-01 | 0.1613 |
10425 | ARIH2 | P57T-E | Human | Esophagus | ESCC | 3.90e-18 | 3.59e-01 | 0.0926 |
10425 | ARIH2 | P61T-E | Human | Esophagus | ESCC | 1.02e-07 | 2.27e-01 | 0.099 |
10425 | ARIH2 | P62T-E | Human | Esophagus | ESCC | 2.94e-33 | 6.65e-01 | 0.1302 |
10425 | ARIH2 | P65T-E | Human | Esophagus | ESCC | 3.69e-14 | 2.65e-01 | 0.0978 |
10425 | ARIH2 | P74T-E | Human | Esophagus | ESCC | 1.75e-40 | 1.20e+00 | 0.1479 |
10425 | ARIH2 | P75T-E | Human | Esophagus | ESCC | 6.75e-49 | 9.85e-01 | 0.1125 |
10425 | ARIH2 | P76T-E | Human | Esophagus | ESCC | 1.73e-19 | 5.22e-01 | 0.1207 |
10425 | ARIH2 | P79T-E | Human | Esophagus | ESCC | 1.48e-40 | 6.83e-01 | 0.1154 |
10425 | ARIH2 | P80T-E | Human | Esophagus | ESCC | 1.85e-42 | 1.39e+00 | 0.155 |
10425 | ARIH2 | P82T-E | Human | Esophagus | ESCC | 7.24e-10 | 6.77e-01 | 0.1072 |
10425 | ARIH2 | P83T-E | Human | Esophagus | ESCC | 4.16e-29 | 1.07e+00 | 0.1738 |
10425 | ARIH2 | P84T-E | Human | Esophagus | ESCC | 8.98e-06 | 4.72e-01 | 0.0933 |
10425 | ARIH2 | P89T-E | Human | Esophagus | ESCC | 4.40e-06 | 6.92e-01 | 0.1752 |
10425 | ARIH2 | P91T-E | Human | Esophagus | ESCC | 2.30e-11 | 9.87e-01 | 0.1828 |
10425 | ARIH2 | P104T-E | Human | Esophagus | ESCC | 5.60e-04 | 5.23e-01 | 0.0931 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217627 | Esophagus | HGIN | regulation of protein catabolic process | 119/2587 | 391/18723 | 8.09e-18 | 2.43e-15 | 119 |
GO:001049826 | Esophagus | HGIN | proteasomal protein catabolic process | 139/2587 | 490/18723 | 1.20e-17 | 3.41e-15 | 139 |
GO:007259420 | Esophagus | HGIN | establishment of protein localization to organelle | 120/2587 | 422/18723 | 1.73e-15 | 4.00e-13 | 120 |
GO:004586227 | Esophagus | HGIN | positive regulation of proteolysis | 107/2587 | 372/18723 | 2.61e-14 | 4.60e-12 | 107 |
GO:004316126 | Esophagus | HGIN | proteasome-mediated ubiquitin-dependent protein catabolic process | 114/2587 | 412/18723 | 7.00e-14 | 1.20e-11 | 114 |
GO:190336227 | Esophagus | HGIN | regulation of cellular protein catabolic process | 81/2587 | 255/18723 | 1.16e-13 | 1.93e-11 | 81 |
GO:000989626 | Esophagus | HGIN | positive regulation of catabolic process | 126/2587 | 492/18723 | 1.46e-12 | 2.09e-10 | 126 |
GO:003133126 | Esophagus | HGIN | positive regulation of cellular catabolic process | 112/2587 | 427/18723 | 5.15e-12 | 6.72e-10 | 112 |
GO:190305027 | Esophagus | HGIN | regulation of proteolysis involved in cellular protein catabolic process | 70/2587 | 221/18723 | 6.21e-12 | 7.76e-10 | 70 |
GO:006113627 | Esophagus | HGIN | regulation of proteasomal protein catabolic process | 60/2587 | 187/18723 | 1.10e-10 | 1.12e-08 | 60 |
GO:000683920 | Esophagus | HGIN | mitochondrial transport | 74/2587 | 254/18723 | 1.32e-10 | 1.32e-08 | 74 |
GO:004573227 | Esophagus | HGIN | positive regulation of protein catabolic process | 69/2587 | 231/18723 | 1.66e-10 | 1.64e-08 | 69 |
GO:200005827 | Esophagus | HGIN | regulation of ubiquitin-dependent protein catabolic process | 53/2587 | 164/18723 | 9.89e-10 | 8.13e-08 | 53 |
GO:190336427 | Esophagus | HGIN | positive regulation of cellular protein catabolic process | 51/2587 | 155/18723 | 1.01e-09 | 8.15e-08 | 51 |
GO:190180020 | Esophagus | HGIN | positive regulation of proteasomal protein catabolic process | 41/2587 | 114/18723 | 2.25e-09 | 1.67e-07 | 41 |
GO:190382926 | Esophagus | HGIN | positive regulation of cellular protein localization | 75/2587 | 276/18723 | 3.19e-09 | 2.30e-07 | 75 |
GO:190305219 | Esophagus | HGIN | positive regulation of proteolysis involved in cellular protein catabolic process | 45/2587 | 133/18723 | 3.55e-09 | 2.53e-07 | 45 |
GO:007058520 | Esophagus | HGIN | protein localization to mitochondrion | 43/2587 | 125/18723 | 4.43e-09 | 3.03e-07 | 43 |
GO:003243427 | Esophagus | HGIN | regulation of proteasomal ubiquitin-dependent protein catabolic process | 45/2587 | 134/18723 | 4.64e-09 | 3.12e-07 | 45 |
GO:007265520 | Esophagus | HGIN | establishment of protein localization to mitochondrion | 41/2587 | 120/18723 | 1.26e-08 | 7.96e-07 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARIH2 | SNV | Missense_Mutation | c.782N>A | p.Arg261His | p.R261H | O95376 | protein_coding | tolerated(0.07) | benign(0.007) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR | |
ARIH2 | SNV | Missense_Mutation | novel | c.1295A>T | p.Tyr432Phe | p.Y432F | O95376 | protein_coding | deleterious(0.03) | possibly_damaging(0.788) | TCGA-UC-A7PD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ARIH2 | SNV | Missense_Mutation | c.980T>C | p.Leu327Pro | p.L327P | O95376 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARIH2 | SNV | Missense_Mutation | c.923G>T | p.Gly308Val | p.G308V | O95376 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-6600-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cpt-11 | PD | |
ARIH2 | SNV | Missense_Mutation | c.760N>A | p.Glu254Lys | p.E254K | O95376 | protein_coding | deleterious(0.03) | possibly_damaging(0.585) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ARIH2 | SNV | Missense_Mutation | novel | c.828N>C | p.Trp276Cys | p.W276C | O95376 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARIH2 | SNV | Missense_Mutation | novel | c.323N>A | p.Arg108Lys | p.R108K | O95376 | protein_coding | tolerated(0.85) | benign(0.014) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARIH2 | SNV | Missense_Mutation | novel | c.323N>T | p.Arg108Ile | p.R108I | O95376 | protein_coding | tolerated(0.14) | possibly_damaging(0.473) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARIH2 | SNV | Missense_Mutation | novel | c.1244N>G | p.Lys415Arg | p.K415R | O95376 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARIH2 | SNV | Missense_Mutation | novel | c.118G>A | p.Val40Met | p.V40M | O95376 | protein_coding | tolerated(0.13) | benign(0.038) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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