Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ARIH2

Gene summary for ARIH2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ARIH2

Gene ID

10425

Gene nameariadne RBR E3 ubiquitin protein ligase 2
Gene AliasARI2
Cytomap3p21.31
Gene Typeprotein-coding
GO ID

GO:0000209

UniProtAcc

O95376


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10425ARIH2P48T-EHumanEsophagusESCC3.15e-192.31e-010.0959
10425ARIH2P49T-EHumanEsophagusESCC1.23e-091.03e+000.1768
10425ARIH2P52T-EHumanEsophagusESCC1.31e-175.00e-010.1555
10425ARIH2P54T-EHumanEsophagusESCC5.02e-123.27e-010.0975
10425ARIH2P56T-EHumanEsophagusESCC8.10e-089.69e-010.1613
10425ARIH2P57T-EHumanEsophagusESCC3.90e-183.59e-010.0926
10425ARIH2P61T-EHumanEsophagusESCC1.02e-072.27e-010.099
10425ARIH2P62T-EHumanEsophagusESCC2.94e-336.65e-010.1302
10425ARIH2P65T-EHumanEsophagusESCC3.69e-142.65e-010.0978
10425ARIH2P74T-EHumanEsophagusESCC1.75e-401.20e+000.1479
10425ARIH2P75T-EHumanEsophagusESCC6.75e-499.85e-010.1125
10425ARIH2P76T-EHumanEsophagusESCC1.73e-195.22e-010.1207
10425ARIH2P79T-EHumanEsophagusESCC1.48e-406.83e-010.1154
10425ARIH2P80T-EHumanEsophagusESCC1.85e-421.39e+000.155
10425ARIH2P82T-EHumanEsophagusESCC7.24e-106.77e-010.1072
10425ARIH2P83T-EHumanEsophagusESCC4.16e-291.07e+000.1738
10425ARIH2P84T-EHumanEsophagusESCC8.98e-064.72e-010.0933
10425ARIH2P89T-EHumanEsophagusESCC4.40e-066.92e-010.1752
10425ARIH2P91T-EHumanEsophagusESCC2.30e-119.87e-010.1828
10425ARIH2P104T-EHumanEsophagusESCC5.60e-045.23e-010.0931
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004217627EsophagusHGINregulation of protein catabolic process119/2587391/187238.09e-182.43e-15119
GO:001049826EsophagusHGINproteasomal protein catabolic process139/2587490/187231.20e-173.41e-15139
GO:007259420EsophagusHGINestablishment of protein localization to organelle120/2587422/187231.73e-154.00e-13120
GO:004586227EsophagusHGINpositive regulation of proteolysis107/2587372/187232.61e-144.60e-12107
GO:004316126EsophagusHGINproteasome-mediated ubiquitin-dependent protein catabolic process114/2587412/187237.00e-141.20e-11114
GO:190336227EsophagusHGINregulation of cellular protein catabolic process81/2587255/187231.16e-131.93e-1181
GO:000989626EsophagusHGINpositive regulation of catabolic process126/2587492/187231.46e-122.09e-10126
GO:003133126EsophagusHGINpositive regulation of cellular catabolic process112/2587427/187235.15e-126.72e-10112
GO:190305027EsophagusHGINregulation of proteolysis involved in cellular protein catabolic process70/2587221/187236.21e-127.76e-1070
GO:006113627EsophagusHGINregulation of proteasomal protein catabolic process60/2587187/187231.10e-101.12e-0860
GO:000683920EsophagusHGINmitochondrial transport74/2587254/187231.32e-101.32e-0874
GO:004573227EsophagusHGINpositive regulation of protein catabolic process69/2587231/187231.66e-101.64e-0869
GO:200005827EsophagusHGINregulation of ubiquitin-dependent protein catabolic process53/2587164/187239.89e-108.13e-0853
GO:190336427EsophagusHGINpositive regulation of cellular protein catabolic process51/2587155/187231.01e-098.15e-0851
GO:190180020EsophagusHGINpositive regulation of proteasomal protein catabolic process41/2587114/187232.25e-091.67e-0741
GO:190382926EsophagusHGINpositive regulation of cellular protein localization75/2587276/187233.19e-092.30e-0775
GO:190305219EsophagusHGINpositive regulation of proteolysis involved in cellular protein catabolic process45/2587133/187233.55e-092.53e-0745
GO:007058520EsophagusHGINprotein localization to mitochondrion43/2587125/187234.43e-093.03e-0743
GO:003243427EsophagusHGINregulation of proteasomal ubiquitin-dependent protein catabolic process45/2587134/187234.64e-093.12e-0745
GO:007265520EsophagusHGINestablishment of protein localization to mitochondrion41/2587120/187231.26e-087.96e-0741
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ARIH2SNVMissense_Mutationc.782N>Ap.Arg261Hisp.R261HO95376protein_codingtolerated(0.07)benign(0.007)TCGA-GM-A2DD-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilCR
ARIH2SNVMissense_Mutationnovelc.1295A>Tp.Tyr432Phep.Y432FO95376protein_codingdeleterious(0.03)possibly_damaging(0.788)TCGA-UC-A7PD-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
ARIH2SNVMissense_Mutationc.980T>Cp.Leu327Prop.L327PO95376protein_codingdeleterious(0)probably_damaging(0.995)TCGA-A6-5661-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
ARIH2SNVMissense_Mutationc.923G>Tp.Gly308Valp.G308VO95376protein_codingdeleterious(0)probably_damaging(0.998)TCGA-AZ-6600-01Colorectumcolon adenocarcinomaMale<65III/IVChemotherapycpt-11PD
ARIH2SNVMissense_Mutationc.760N>Ap.Glu254Lysp.E254KO95376protein_codingdeleterious(0.03)possibly_damaging(0.585)TCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
ARIH2SNVMissense_Mutationnovelc.828N>Cp.Trp276Cysp.W276CO95376protein_codingdeleterious(0)probably_damaging(0.993)TCGA-F5-6814-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
ARIH2SNVMissense_Mutationnovelc.323N>Ap.Arg108Lysp.R108KO95376protein_codingtolerated(0.85)benign(0.014)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
ARIH2SNVMissense_Mutationnovelc.323N>Tp.Arg108Ilep.R108IO95376protein_codingtolerated(0.14)possibly_damaging(0.473)TCGA-A5-A1OF-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ARIH2SNVMissense_Mutationnovelc.1244N>Gp.Lys415Argp.K415RO95376protein_codingtolerated(0.41)benign(0.001)TCGA-A5-A1OF-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ARIH2SNVMissense_Mutationnovelc.118G>Ap.Val40Metp.V40MO95376protein_codingtolerated(0.13)benign(0.038)TCGA-AJ-A3EK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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