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Gene: ARHGAP1 |
Gene summary for ARHGAP1 |
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Gene information | Species | Human | Gene symbol | ARHGAP1 | Gene ID | 392 |
Gene name | Rho GTPase activating protein 1 | |
Gene Alias | CDC42GAP | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q07960 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
392 | ARHGAP1 | P4T-E | Human | Esophagus | ESCC | 3.60e-10 | 2.43e-01 | 0.1323 |
392 | ARHGAP1 | P5T-E | Human | Esophagus | ESCC | 1.74e-03 | 8.12e-02 | 0.1327 |
392 | ARHGAP1 | P8T-E | Human | Esophagus | ESCC | 5.10e-24 | 4.06e-01 | 0.0889 |
392 | ARHGAP1 | P9T-E | Human | Esophagus | ESCC | 1.69e-14 | 2.93e-01 | 0.1131 |
392 | ARHGAP1 | P10T-E | Human | Esophagus | ESCC | 1.05e-13 | 2.39e-01 | 0.116 |
392 | ARHGAP1 | P11T-E | Human | Esophagus | ESCC | 1.18e-28 | 9.54e-01 | 0.1426 |
392 | ARHGAP1 | P12T-E | Human | Esophagus | ESCC | 1.52e-14 | 2.25e-01 | 0.1122 |
392 | ARHGAP1 | P15T-E | Human | Esophagus | ESCC | 3.45e-28 | 4.29e-01 | 0.1149 |
392 | ARHGAP1 | P16T-E | Human | Esophagus | ESCC | 1.40e-18 | 3.84e-01 | 0.1153 |
392 | ARHGAP1 | P17T-E | Human | Esophagus | ESCC | 7.78e-17 | 5.12e-01 | 0.1278 |
392 | ARHGAP1 | P19T-E | Human | Esophagus | ESCC | 4.94e-13 | 7.38e-01 | 0.1662 |
392 | ARHGAP1 | P20T-E | Human | Esophagus | ESCC | 9.57e-18 | 3.04e-01 | 0.1124 |
392 | ARHGAP1 | P21T-E | Human | Esophagus | ESCC | 1.42e-31 | 5.90e-01 | 0.1617 |
392 | ARHGAP1 | P22T-E | Human | Esophagus | ESCC | 1.60e-17 | 2.46e-01 | 0.1236 |
392 | ARHGAP1 | P23T-E | Human | Esophagus | ESCC | 1.28e-18 | 4.23e-01 | 0.108 |
392 | ARHGAP1 | P24T-E | Human | Esophagus | ESCC | 7.19e-14 | 3.87e-01 | 0.1287 |
392 | ARHGAP1 | P26T-E | Human | Esophagus | ESCC | 3.43e-10 | 1.92e-01 | 0.1276 |
392 | ARHGAP1 | P27T-E | Human | Esophagus | ESCC | 7.39e-13 | 2.47e-01 | 0.1055 |
392 | ARHGAP1 | P28T-E | Human | Esophagus | ESCC | 7.29e-14 | 3.01e-01 | 0.1149 |
392 | ARHGAP1 | P30T-E | Human | Esophagus | ESCC | 1.80e-11 | 5.13e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:005125810 | Cervix | CC | protein polymerization | 70/2311 | 297/18723 | 5.20e-08 | 3.11e-06 | 70 |
GO:003227110 | Cervix | CC | regulation of protein polymerization | 57/2311 | 233/18723 | 2.37e-07 | 1.03e-05 | 57 |
GO:00081549 | Cervix | CC | actin polymerization or depolymerization | 51/2311 | 218/18723 | 4.05e-06 | 1.05e-04 | 51 |
GO:00300419 | Cervix | CC | actin filament polymerization | 45/2311 | 191/18723 | 1.20e-05 | 2.54e-04 | 45 |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:00083608 | Cervix | CC | regulation of cell shape | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:00308339 | Cervix | CC | regulation of actin filament polymerization | 40/2311 | 172/18723 | 4.90e-05 | 7.40e-04 | 40 |
GO:00080649 | Cervix | CC | regulation of actin polymerization or depolymerization | 42/2311 | 188/18723 | 8.60e-05 | 1.15e-03 | 42 |
GO:00308328 | Cervix | CC | regulation of actin filament length | 42/2311 | 189/18723 | 9.76e-05 | 1.27e-03 | 42 |
GO:000701515 | Cervix | HSIL_HPV | actin filament organization | 43/737 | 442/18723 | 4.77e-08 | 3.59e-06 | 43 |
GO:003295615 | Cervix | HSIL_HPV | regulation of actin cytoskeleton organization | 33/737 | 358/18723 | 5.61e-06 | 2.09e-04 | 33 |
GO:003297015 | Cervix | HSIL_HPV | regulation of actin filament-based process | 35/737 | 397/18723 | 7.87e-06 | 2.81e-04 | 35 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP1 | SNV | Missense_Mutation | c.730N>T | p.Val244Phe | p.V244F | Q07960 | protein_coding | deleterious(0) | possibly_damaging(0.713) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP1 | SNV | Missense_Mutation | rs760960194 | c.205N>T | p.Arg69Trp | p.R69W | Q07960 | protein_coding | deleterious(0.01) | benign(0.049) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP1 | deletion | Frame_Shift_Del | novel | c.178_179delNN | p.Trp60GlyfsTer2 | p.W60Gfs*2 | Q07960 | protein_coding | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ARHGAP1 | SNV | Missense_Mutation | rs764362910 | c.394N>A | p.Asp132Asn | p.D132N | Q07960 | protein_coding | tolerated(0.16) | benign(0.01) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARHGAP1 | SNV | Missense_Mutation | novel | c.421N>T | p.Arg141Cys | p.R141C | Q07960 | protein_coding | deleterious(0.02) | probably_damaging(0.985) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGAP1 | SNV | Missense_Mutation | novel | c.232N>T | p.Asp78Tyr | p.D78Y | Q07960 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ARHGAP1 | SNV | Missense_Mutation | novel | c.1253C>T | p.Thr418Ile | p.T418I | Q07960 | protein_coding | tolerated(0.43) | benign(0.023) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP1 | SNV | Missense_Mutation | c.1222A>G | p.Ile408Val | p.I408V | Q07960 | protein_coding | tolerated(1) | benign(0.003) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ARHGAP1 | SNV | Missense_Mutation | rs754102804 | c.872N>A | p.Arg291Gln | p.R291Q | Q07960 | protein_coding | tolerated(0.07) | benign(0.173) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP1 | SNV | Missense_Mutation | novel | c.1145N>A | p.Ser382Asn | p.S382N | Q07960 | protein_coding | deleterious(0.02) | benign(0.019) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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