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Gene: APOD |
Gene summary for APOD |
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Gene information | Species | Human | Gene symbol | APOD | Gene ID | 347 |
Gene name | apolipoprotein D | |
Gene Alias | APOD | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | P05090 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
347 | APOD | P130T-E | Human | Esophagus | ESCC | 4.82e-78 | 1.98e+00 | 0.1676 |
347 | APOD | NEOLP-1 | Human | Oral cavity | NEOLP | 2.92e-07 | 3.84e-01 | -0.0194 |
347 | APOD | SYSMH1 | Human | Oral cavity | OSCC | 7.87e-03 | -2.26e-01 | 0.1127 |
347 | APOD | SYSMH4 | Human | Oral cavity | OSCC | 3.50e-02 | -2.26e-01 | 0.1226 |
347 | APOD | SYSMH5 | Human | Oral cavity | OSCC | 1.66e-02 | -2.28e-01 | 0.0647 |
347 | APOD | P1_S1_AK | Human | Skin | AK | 2.71e-54 | -1.35e+00 | -0.3399 |
347 | APOD | P2_S3_AK | Human | Skin | AK | 3.76e-53 | -1.37e+00 | -0.3287 |
347 | APOD | P2_S4_SCCIS | Human | Skin | SCCIS | 5.26e-48 | -1.36e+00 | -0.3043 |
347 | APOD | P3_S6_AK | Human | Skin | AK | 7.92e-48 | -1.31e+00 | -0.3256 |
347 | APOD | P4_S8_cSCC | Human | Skin | cSCC | 1.79e-30 | -1.32e+00 | -0.3095 |
347 | APOD | P5_S10_cSCC | Human | Skin | cSCC | 4.74e-56 | -1.37e+00 | -0.299 |
347 | APOD | P1_cSCC | Human | Skin | cSCC | 1.96e-30 | -1.34e+00 | 0.0292 |
347 | APOD | P2_cSCC | Human | Skin | cSCC | 3.88e-55 | -1.36e+00 | -0.024 |
347 | APOD | P4_cSCC | Human | Skin | cSCC | 3.41e-34 | -1.24e+00 | -0.00290000000000005 |
347 | APOD | P10_cSCC | Human | Skin | cSCC | 2.15e-43 | -1.28e+00 | 0.1017 |
347 | APOD | cSCC_p1 | Human | Skin | cSCC | 6.55e-53 | -1.37e+00 | -0.1916 |
347 | APOD | cSCC_p10 | Human | Skin | cSCC | 4.66e-58 | -1.37e+00 | -0.2095 |
347 | APOD | cSCC_p11 | Human | Skin | cSCC | 5.82e-53 | -1.37e+00 | -0.2102 |
347 | APOD | cSCC_p3 | Human | Skin | cSCC | 3.78e-49 | -1.33e+00 | -0.2085 |
347 | APOD | cSCC_p4 | Human | Skin | cSCC | 2.64e-46 | -1.36e+00 | -0.2022 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697914 | Breast | IDC | response to oxidative stress | 83/1434 | 446/18723 | 2.36e-14 | 7.06e-12 | 83 |
GO:000030214 | Breast | IDC | response to reactive oxygen species | 46/1434 | 222/18723 | 4.12e-10 | 4.59e-08 | 46 |
GO:000756813 | Breast | IDC | aging | 52/1434 | 339/18723 | 1.14e-06 | 5.10e-05 | 52 |
GO:005090011 | Breast | IDC | leukocyte migration | 54/1434 | 369/18723 | 3.10e-06 | 1.15e-04 | 54 |
GO:000941013 | Breast | IDC | response to xenobiotic stimulus | 62/1434 | 462/18723 | 1.05e-05 | 2.88e-04 | 62 |
GO:000268511 | Breast | IDC | regulation of leukocyte migration | 33/1434 | 210/18723 | 6.10e-05 | 1.27e-03 | 33 |
GO:003109912 | Breast | IDC | regeneration | 31/1434 | 198/18723 | 1.08e-04 | 2.03e-03 | 31 |
GO:001921612 | Breast | IDC | regulation of lipid metabolic process | 45/1434 | 331/18723 | 1.21e-04 | 2.24e-03 | 45 |
GO:000268311 | Breast | IDC | negative regulation of immune system process | 55/1434 | 434/18723 | 1.53e-04 | 2.67e-03 | 55 |
GO:00512712 | Breast | IDC | negative regulation of cellular component movement | 48/1434 | 367/18723 | 1.88e-04 | 3.12e-03 | 48 |
GO:20001462 | Breast | IDC | negative regulation of cell motility | 46/1434 | 359/18723 | 4.01e-04 | 5.60e-03 | 46 |
GO:007167511 | Breast | IDC | regulation of mononuclear cell migration | 20/1434 | 115/18723 | 4.35e-04 | 5.90e-03 | 20 |
GO:007167411 | Breast | IDC | mononuclear cell migration | 29/1434 | 196/18723 | 4.68e-04 | 6.26e-03 | 29 |
GO:007259413 | Breast | IDC | establishment of protein localization to organelle | 51/1434 | 422/18723 | 7.94e-04 | 9.55e-03 | 51 |
GO:00303362 | Breast | IDC | negative regulation of cell migration | 43/1434 | 344/18723 | 1.01e-03 | 1.13e-02 | 43 |
GO:00400132 | Breast | IDC | negative regulation of locomotion | 47/1434 | 391/18723 | 1.39e-03 | 1.43e-02 | 47 |
GO:00486592 | Breast | IDC | smooth muscle cell proliferation | 26/1434 | 184/18723 | 1.77e-03 | 1.72e-02 | 26 |
GO:00486602 | Breast | IDC | regulation of smooth muscle cell proliferation | 25/1434 | 180/18723 | 2.71e-03 | 2.41e-02 | 25 |
GO:00071625 | Breast | IDC | negative regulation of cell adhesion | 37/1434 | 303/18723 | 3.27e-03 | 2.75e-02 | 37 |
GO:2000404 | Breast | IDC | regulation of T cell migration | 9/1434 | 42/18723 | 3.91e-03 | 3.20e-02 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APOD | SNV | Missense_Mutation | novel | c.254N>C | p.Gly85Ala | p.G85A | P05090 | protein_coding | deleterious(0.04) | possibly_damaging(0.899) | TCGA-OL-A5RZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
APOD | insertion | Nonsense_Mutation | novel | c.145_146insCCTAGCAAGACAGGCT | p.Ile49ThrfsTer2 | p.I49Tfs*2 | P05090 | protein_coding | TCGA-OL-A66P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR | ||
APOD | SNV | Missense_Mutation | rs5954 | c.344N>T | p.Ser115Leu | p.S115L | P05090 | protein_coding | tolerated(0.57) | benign(0.23) | TCGA-JW-A5VJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
APOD | SNV | Missense_Mutation | rs5954 | c.344C>T | p.Ser115Leu | p.S115L | P05090 | protein_coding | tolerated(0.57) | benign(0.23) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
APOD | SNV | Missense_Mutation | rs5954 | c.344C>T | p.Ser115Leu | p.S115L | P05090 | protein_coding | tolerated(0.57) | benign(0.23) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
APOD | SNV | Missense_Mutation | c.53N>T | p.Ala18Val | p.A18V | P05090 | protein_coding | tolerated(0.21) | benign(0.254) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
APOD | SNV | Missense_Mutation | novel | c.153N>T | p.Lys51Asn | p.K51N | P05090 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
APOD | SNV | Missense_Mutation | c.277G>C | p.Glu93Gln | p.E93Q | P05090 | protein_coding | tolerated(0.29) | benign(0.026) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
APOD | SNV | Missense_Mutation | rs201787147 | c.370N>A | p.Asp124Asn | p.D124N | P05090 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
APOD | SNV | Missense_Mutation | rs5954 | c.344N>T | p.Ser115Leu | p.S115L | P05090 | protein_coding | tolerated(0.57) | benign(0.23) | TCGA-NH-A50U-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
347 | APOD | DRUGGABLE GENOME, ENZYME | RETINOIDS | 8943263 |
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