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Gene: AKAP8 |
Gene summary for AKAP8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | AKAP8 | Gene ID | 10270 |
| Gene name | A-kinase anchoring protein 8 | |
| Gene Alias | AKAP 95 | |
| Cytomap | 19p13.12 | |
| Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | O43823 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10270 | AKAP8 | P57T-E | Human | Esophagus | ESCC | 1.00e-11 | 1.83e-01 | 0.0926 |
| 10270 | AKAP8 | P61T-E | Human | Esophagus | ESCC | 4.78e-14 | 3.16e-01 | 0.099 |
| 10270 | AKAP8 | P62T-E | Human | Esophagus | ESCC | 1.01e-24 | 4.43e-01 | 0.1302 |
| 10270 | AKAP8 | P65T-E | Human | Esophagus | ESCC | 1.75e-11 | 1.79e-01 | 0.0978 |
| 10270 | AKAP8 | P74T-E | Human | Esophagus | ESCC | 9.84e-13 | 2.81e-01 | 0.1479 |
| 10270 | AKAP8 | P75T-E | Human | Esophagus | ESCC | 4.61e-22 | 3.70e-01 | 0.1125 |
| 10270 | AKAP8 | P76T-E | Human | Esophagus | ESCC | 2.76e-10 | 2.55e-01 | 0.1207 |
| 10270 | AKAP8 | P79T-E | Human | Esophagus | ESCC | 3.02e-23 | 2.80e-01 | 0.1154 |
| 10270 | AKAP8 | P80T-E | Human | Esophagus | ESCC | 1.24e-20 | 6.10e-01 | 0.155 |
| 10270 | AKAP8 | P82T-E | Human | Esophagus | ESCC | 3.53e-07 | 3.59e-01 | 0.1072 |
| 10270 | AKAP8 | P83T-E | Human | Esophagus | ESCC | 3.17e-13 | 3.72e-01 | 0.1738 |
| 10270 | AKAP8 | P84T-E | Human | Esophagus | ESCC | 6.02e-07 | 3.21e-01 | 0.0933 |
| 10270 | AKAP8 | P89T-E | Human | Esophagus | ESCC | 1.49e-06 | 6.42e-01 | 0.1752 |
| 10270 | AKAP8 | P91T-E | Human | Esophagus | ESCC | 7.89e-11 | 9.05e-01 | 0.1828 |
| 10270 | AKAP8 | P104T-E | Human | Esophagus | ESCC | 3.74e-03 | 9.26e-02 | 0.0931 |
| 10270 | AKAP8 | P107T-E | Human | Esophagus | ESCC | 1.93e-28 | 6.30e-01 | 0.171 |
| 10270 | AKAP8 | P127T-E | Human | Esophagus | ESCC | 1.41e-13 | 2.22e-01 | 0.0826 |
| 10270 | AKAP8 | P128T-E | Human | Esophagus | ESCC | 2.26e-17 | 6.45e-01 | 0.1241 |
| 10270 | AKAP8 | P130T-E | Human | Esophagus | ESCC | 4.16e-35 | 7.44e-01 | 0.1676 |
| 10270 | AKAP8 | C04 | Human | Oral cavity | OSCC | 3.66e-09 | 3.98e-01 | 0.2633 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
| GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
| GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
| GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
| GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
| GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
| GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
| GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
| GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
| GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
| GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
| GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
| GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
| GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
| GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
| GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
| GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
| GO:0046822110 | Esophagus | ESCC | regulation of nucleocytoplasmic transport | 88/8552 | 106/18723 | 1.88e-15 | 1.19e-13 | 88 |
| GO:007116612 | Esophagus | ESCC | ribonucleoprotein complex localization | 66/8552 | 77/18723 | 2.94e-13 | 1.38e-11 | 66 |
| GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| AKAP8 | SNV | Missense_Mutation | rs764482753 | c.1192N>T | p.Arg398Cys | p.R398C | O43823 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| AKAP8 | SNV | Missense_Mutation | novel | c.1489C>T | p.Arg497Trp | p.R497W | O43823 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
| AKAP8 | SNV | Missense_Mutation | rs767177827 | c.1268C>G | p.Thr423Ser | p.T423S | O43823 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| AKAP8 | SNV | Missense_Mutation | c.1600A>C | p.Lys534Gln | p.K534Q | O43823 | protein_coding | deleterious(0.02) | probably_damaging(0.939) | TCGA-E2-A1L7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | |
| AKAP8 | SNV | Missense_Mutation | novel | c.1997N>C | p.Arg666Thr | p.R666T | O43823 | protein_coding | tolerated_low_confidence(0.6) | benign(0.005) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
| AKAP8 | SNV | Missense_Mutation | c.1581N>C | p.Leu527Phe | p.L527F | O43823 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
| AKAP8 | SNV | Missense_Mutation | c.374C>T | p.Ser125Phe | p.S125F | O43823 | protein_coding | deleterious(0.05) | benign(0.072) | TCGA-EK-A3GN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
| AKAP8 | SNV | Missense_Mutation | novel | c.1015T>G | p.Ser339Ala | p.S339A | O43823 | protein_coding | tolerated(0.09) | possibly_damaging(0.565) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| AKAP8 | SNV | Missense_Mutation | c.712N>T | p.Pro238Ser | p.P238S | O43823 | protein_coding | tolerated(0.08) | benign(0.062) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| AKAP8 | SNV | Missense_Mutation | c.2006N>T | p.Pro669Leu | p.P669L | O43823 | protein_coding | tolerated_low_confidence(0.3) | benign(0) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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