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Gene: AIMP2 |
Gene summary for AIMP2 |
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Gene information | Species | Human | Gene symbol | AIMP2 | Gene ID | 7965 |
Gene name | aminoacyl tRNA synthetase complex interacting multifunctional protein 2 | |
Gene Alias | HLD17 | |
Cytomap | 7p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | F8W950 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7965 | AIMP2 | P42T-E | Human | Esophagus | ESCC | 2.48e-21 | 7.77e-01 | 0.1175 |
7965 | AIMP2 | P44T-E | Human | Esophagus | ESCC | 5.29e-09 | 3.50e-01 | 0.1096 |
7965 | AIMP2 | P47T-E | Human | Esophagus | ESCC | 3.10e-36 | 5.96e-01 | 0.1067 |
7965 | AIMP2 | P48T-E | Human | Esophagus | ESCC | 8.90e-21 | 4.40e-01 | 0.0959 |
7965 | AIMP2 | P49T-E | Human | Esophagus | ESCC | 7.71e-11 | 1.26e+00 | 0.1768 |
7965 | AIMP2 | P52T-E | Human | Esophagus | ESCC | 4.37e-49 | 1.11e+00 | 0.1555 |
7965 | AIMP2 | P54T-E | Human | Esophagus | ESCC | 1.06e-33 | 8.48e-01 | 0.0975 |
7965 | AIMP2 | P56T-E | Human | Esophagus | ESCC | 1.07e-04 | 1.03e+00 | 0.1613 |
7965 | AIMP2 | P57T-E | Human | Esophagus | ESCC | 9.07e-27 | 6.13e-01 | 0.0926 |
7965 | AIMP2 | P61T-E | Human | Esophagus | ESCC | 5.12e-25 | 6.78e-01 | 0.099 |
7965 | AIMP2 | P62T-E | Human | Esophagus | ESCC | 7.94e-53 | 1.09e+00 | 0.1302 |
7965 | AIMP2 | P65T-E | Human | Esophagus | ESCC | 5.93e-26 | 5.03e-01 | 0.0978 |
7965 | AIMP2 | P74T-E | Human | Esophagus | ESCC | 2.48e-36 | 1.14e+00 | 0.1479 |
7965 | AIMP2 | P75T-E | Human | Esophagus | ESCC | 7.38e-75 | 1.30e+00 | 0.1125 |
7965 | AIMP2 | P76T-E | Human | Esophagus | ESCC | 2.04e-42 | 8.63e-01 | 0.1207 |
7965 | AIMP2 | P79T-E | Human | Esophagus | ESCC | 2.75e-36 | 6.36e-01 | 0.1154 |
7965 | AIMP2 | P80T-E | Human | Esophagus | ESCC | 3.17e-44 | 1.31e+00 | 0.155 |
7965 | AIMP2 | P82T-E | Human | Esophagus | ESCC | 8.63e-26 | 1.14e+00 | 0.1072 |
7965 | AIMP2 | P83T-E | Human | Esophagus | ESCC | 3.07e-63 | 1.90e+00 | 0.1738 |
7965 | AIMP2 | P84T-E | Human | Esophagus | ESCC | 1.60e-03 | 4.38e-01 | 0.0933 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332027 | Esophagus | HGIN | regulation of protein modification by small protein conjugation or removal | 78/2587 | 242/18723 | 1.40e-13 | 2.26e-11 | 78 |
GO:003139627 | Esophagus | HGIN | regulation of protein ubiquitination | 64/2587 | 210/18723 | 3.02e-10 | 2.71e-08 | 64 |
GO:007099727 | Esophagus | HGIN | neuron death | 81/2587 | 361/18723 | 5.01e-06 | 1.61e-04 | 81 |
GO:190121424 | Esophagus | HGIN | regulation of neuron death | 68/2587 | 319/18723 | 1.46e-04 | 2.91e-03 | 68 |
GO:19033228 | Esophagus | HGIN | positive regulation of protein modification by small protein conjugation or removal | 35/2587 | 138/18723 | 2.11e-04 | 3.88e-03 | 35 |
GO:190121625 | Esophagus | HGIN | positive regulation of neuron death | 27/2587 | 97/18723 | 2.16e-04 | 3.96e-03 | 27 |
GO:00313987 | Esophagus | HGIN | positive regulation of protein ubiquitination | 28/2587 | 119/18723 | 2.89e-03 | 2.81e-02 | 28 |
GO:00604794 | Esophagus | HGIN | lung cell differentiation | 9/2587 | 24/18723 | 3.33e-03 | 3.12e-02 | 9 |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:0031396111 | Esophagus | ESCC | regulation of protein ubiquitination | 154/8552 | 210/18723 | 2.70e-16 | 2.04e-14 | 154 |
GO:190332216 | Esophagus | ESCC | positive regulation of protein modification by small protein conjugation or removal | 99/8552 | 138/18723 | 4.39e-10 | 1.16e-08 | 99 |
GO:0070997111 | Esophagus | ESCC | neuron death | 216/8552 | 361/18723 | 3.49e-08 | 6.45e-07 | 216 |
GO:003139816 | Esophagus | ESCC | positive regulation of protein ubiquitination | 82/8552 | 119/18723 | 2.41e-07 | 3.64e-06 | 82 |
GO:1901214111 | Esophagus | ESCC | regulation of neuron death | 186/8552 | 319/18723 | 3.35e-06 | 3.73e-05 | 186 |
GO:00303239 | Esophagus | ESCC | respiratory tube development | 112/8552 | 181/18723 | 7.82e-06 | 7.69e-05 | 112 |
GO:00605417 | Esophagus | ESCC | respiratory system development | 123/8552 | 203/18723 | 1.26e-05 | 1.15e-04 | 123 |
GO:00303249 | Esophagus | ESCC | lung development | 109/8552 | 177/18723 | 1.40e-05 | 1.27e-04 | 109 |
GO:1901216111 | Esophagus | ESCC | positive regulation of neuron death | 65/8552 | 97/18723 | 1.76e-05 | 1.56e-04 | 65 |
GO:00604284 | Esophagus | ESCC | lung epithelium development | 27/8552 | 37/18723 | 7.00e-04 | 3.66e-03 | 27 |
GO:006047913 | Esophagus | ESCC | lung cell differentiation | 18/8552 | 24/18723 | 3.43e-03 | 1.41e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AIMP2 | SNV | Missense_Mutation | novel | c.170C>T | p.Ser57Phe | p.S57F | Q13155 | protein_coding | tolerated(0.11) | benign(0.307) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AIMP2 | SNV | Missense_Mutation | novel | c.392C>T | p.Pro131Leu | p.P131L | Q13155 | protein_coding | deleterious(0.01) | probably_damaging(0.938) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AIMP2 | SNV | Missense_Mutation | rs368275022 | c.154N>G | p.Leu52Val | p.L52V | Q13155 | protein_coding | tolerated(0.55) | benign(0.056) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
AIMP2 | SNV | Missense_Mutation | c.241C>G | p.Gln81Glu | p.Q81E | Q13155 | protein_coding | tolerated(0.13) | benign(0.073) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
AIMP2 | SNV | Missense_Mutation | rs368275022 | c.154C>G | p.Leu52Val | p.L52V | Q13155 | protein_coding | tolerated(0.55) | benign(0.056) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
AIMP2 | SNV | Missense_Mutation | rs764368950 | c.365N>C | p.Ile122Thr | p.I122T | Q13155 | protein_coding | deleterious(0) | possibly_damaging(0.858) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AIMP2 | SNV | Missense_Mutation | rs75895975 | c.461N>T | p.Thr154Met | p.T154M | Q13155 | protein_coding | tolerated(0.14) | benign(0.237) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AIMP2 | SNV | Missense_Mutation | rs764843355 | c.457N>T | p.His153Tyr | p.H153Y | Q13155 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
AIMP2 | SNV | Missense_Mutation | rs747974072 | c.383N>T | p.Pro128Leu | p.P128L | Q13155 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DM-A1HA-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
AIMP2 | SNV | Missense_Mutation | c.542N>T | p.Tyr181Phe | p.Y181F | Q13155 | protein_coding | tolerated(0.53) | benign(0.006) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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