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Gene: ADRBK1 |
Gene summary for ADRBK1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ADRBK1 | Gene ID | 156 |
| Gene name | G protein-coupled receptor kinase 2 | |
| Gene Alias | ADRBK1 | |
| Cytomap | 11q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0002026 | UniProtAcc | A0A0S2Z392 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 156 | ADRBK1 | P74T-E | Human | Esophagus | ESCC | 2.07e-18 | 4.43e-01 | 0.1479 |
| 156 | ADRBK1 | P75T-E | Human | Esophagus | ESCC | 1.25e-26 | 4.45e-01 | 0.1125 |
| 156 | ADRBK1 | P76T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.15e-01 | 0.1207 |
| 156 | ADRBK1 | P79T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.58e-01 | 0.1154 |
| 156 | ADRBK1 | P80T-E | Human | Esophagus | ESCC | 2.66e-23 | 5.17e-01 | 0.155 |
| 156 | ADRBK1 | P82T-E | Human | Esophagus | ESCC | 4.96e-16 | 5.01e-01 | 0.1072 |
| 156 | ADRBK1 | P83T-E | Human | Esophagus | ESCC | 5.54e-12 | 2.89e-01 | 0.1738 |
| 156 | ADRBK1 | P84T-E | Human | Esophagus | ESCC | 1.34e-04 | 2.67e-01 | 0.0933 |
| 156 | ADRBK1 | P89T-E | Human | Esophagus | ESCC | 6.19e-09 | 3.92e-01 | 0.1752 |
| 156 | ADRBK1 | P91T-E | Human | Esophagus | ESCC | 1.72e-16 | 9.48e-01 | 0.1828 |
| 156 | ADRBK1 | P94T-E | Human | Esophagus | ESCC | 6.05e-03 | 2.95e-01 | 0.0879 |
| 156 | ADRBK1 | P104T-E | Human | Esophagus | ESCC | 4.25e-08 | 4.69e-01 | 0.0931 |
| 156 | ADRBK1 | P107T-E | Human | Esophagus | ESCC | 1.88e-20 | 3.90e-01 | 0.171 |
| 156 | ADRBK1 | P126T-E | Human | Esophagus | ESCC | 4.97e-07 | 6.10e-01 | 0.1125 |
| 156 | ADRBK1 | P127T-E | Human | Esophagus | ESCC | 4.99e-20 | 3.70e-01 | 0.0826 |
| 156 | ADRBK1 | P128T-E | Human | Esophagus | ESCC | 7.29e-27 | 7.47e-01 | 0.1241 |
| 156 | ADRBK1 | P130T-E | Human | Esophagus | ESCC | 2.55e-31 | 4.80e-01 | 0.1676 |
| 156 | ADRBK1 | C04 | Human | Oral cavity | OSCC | 3.68e-11 | 5.87e-01 | 0.2633 |
| 156 | ADRBK1 | C21 | Human | Oral cavity | OSCC | 3.46e-31 | 7.54e-01 | 0.2678 |
| 156 | ADRBK1 | C30 | Human | Oral cavity | OSCC | 1.30e-20 | 8.87e-01 | 0.3055 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
| hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
| hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
| hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
| hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
| hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
| hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
| hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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