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Gene: ADH7 |
Gene summary for ADH7 |
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Gene information | Species | Human | Gene symbol | ADH7 | Gene ID | 131 |
Gene name | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | |
Gene Alias | ADH4 | |
Cytomap | 4q23 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | P40394 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
131 | ADH7 | P107T-E | Human | Esophagus | ESCC | 1.29e-17 | 6.86e-01 | 0.171 |
131 | ADH7 | P127T-E | Human | Esophagus | ESCC | 8.54e-46 | 9.50e-01 | 0.0826 |
131 | ADH7 | P128T-E | Human | Esophagus | ESCC | 1.31e-13 | 5.88e-01 | 0.1241 |
131 | ADH7 | C46 | Human | Oral cavity | OSCC | 2.16e-41 | 1.06e+00 | 0.1673 |
131 | ADH7 | C57 | Human | Oral cavity | OSCC | 8.77e-04 | 4.76e-01 | 0.1679 |
131 | ADH7 | C08 | Human | Oral cavity | OSCC | 1.47e-56 | 1.99e+00 | 0.1919 |
131 | ADH7 | LN22 | Human | Oral cavity | OSCC | 2.15e-16 | 2.21e+00 | 0.1733 |
131 | ADH7 | LN46 | Human | Oral cavity | OSCC | 1.43e-03 | 4.63e-01 | 0.1666 |
131 | ADH7 | SYSMH1 | Human | Oral cavity | OSCC | 1.06e-15 | 5.64e-01 | 0.1127 |
131 | ADH7 | SYSMH4 | Human | Oral cavity | OSCC | 1.14e-07 | 2.76e-01 | 0.1226 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000609120 | Esophagus | HGIN | generation of precursor metabolites and energy | 145/2587 | 490/18723 | 3.41e-20 | 2.04e-17 | 145 |
GO:009730520 | Esophagus | HGIN | response to alcohol | 54/2587 | 253/18723 | 6.46e-04 | 8.87e-03 | 54 |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:00193958 | Esophagus | ESCC | fatty acid oxidation | 69/8552 | 103/18723 | 9.95e-06 | 9.44e-05 | 69 |
GO:00344407 | Esophagus | ESCC | lipid oxidation | 71/8552 | 108/18723 | 2.00e-05 | 1.74e-04 | 71 |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:0097305111 | Esophagus | ESCC | response to alcohol | 138/8552 | 253/18723 | 2.70e-03 | 1.14e-02 | 138 |
GO:00302586 | Esophagus | ESCC | lipid modification | 116/8552 | 212/18723 | 4.90e-03 | 1.89e-02 | 116 |
GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
GO:00060667 | Oral cavity | OSCC | alcohol metabolic process | 179/7305 | 353/18723 | 4.54e-06 | 5.21e-05 | 179 |
GO:009730519 | Oral cavity | OSCC | response to alcohol | 127/7305 | 253/18723 | 1.81e-04 | 1.24e-03 | 127 |
GO:00066317 | Oral cavity | OSCC | fatty acid metabolic process | 186/7305 | 390/18723 | 2.65e-04 | 1.69e-03 | 186 |
GO:00193957 | Oral cavity | OSCC | fatty acid oxidation | 57/7305 | 103/18723 | 5.58e-04 | 3.23e-03 | 57 |
GO:00344406 | Oral cavity | OSCC | lipid oxidation | 59/7305 | 108/18723 | 7.01e-04 | 3.89e-03 | 59 |
GO:00067203 | Oral cavity | OSCC | isoprenoid metabolic process | 59/7305 | 116/18723 | 6.18e-03 | 2.33e-02 | 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0062010 | Esophagus | HGIN | Pyruvate metabolism | 16/1383 | 47/8465 | 2.27e-03 | 1.95e-02 | 1.55e-02 | 16 |
hsa0062013 | Esophagus | HGIN | Pyruvate metabolism | 16/1383 | 47/8465 | 2.27e-03 | 1.95e-02 | 1.55e-02 | 16 |
hsa0062023 | Esophagus | ESCC | Pyruvate metabolism | 32/4205 | 47/8465 | 8.11e-03 | 1.94e-02 | 9.94e-03 | 32 |
hsa0001016 | Esophagus | ESCC | Glycolysis / Gluconeogenesis | 42/4205 | 67/8465 | 2.15e-02 | 4.78e-02 | 2.45e-02 | 42 |
hsa0062033 | Esophagus | ESCC | Pyruvate metabolism | 32/4205 | 47/8465 | 8.11e-03 | 1.94e-02 | 9.94e-03 | 32 |
hsa0001017 | Esophagus | ESCC | Glycolysis / Gluconeogenesis | 42/4205 | 67/8465 | 2.15e-02 | 4.78e-02 | 2.45e-02 | 42 |
hsa049365 | Oral cavity | OSCC | Alcoholic liver disease | 78/3704 | 142/8465 | 4.53e-03 | 1.12e-02 | 5.68e-03 | 78 |
hsa0493612 | Oral cavity | OSCC | Alcoholic liver disease | 78/3704 | 142/8465 | 4.53e-03 | 1.12e-02 | 5.68e-03 | 78 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADH7 | SNV | Missense_Mutation | c.943N>T | p.Pro315Ser | p.P315S | P40394 | protein_coding | tolerated(0.17) | possibly_damaging(0.503) | TCGA-BH-A18M-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ADH7 | SNV | Missense_Mutation | c.632N>T | p.Pro211Leu | p.P211L | P40394 | protein_coding | deleterious(0.01) | possibly_damaging(0.616) | TCGA-EW-A1OY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ADH7 | insertion | Frame_Shift_Ins | novel | c.232_233insC | p.Met78ThrfsTer12 | p.M78Tfs*12 | P40394 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
ADH7 | deletion | Frame_Shift_Del | novel | c.479delN | p.Phe160SerfsTer2 | p.F160Sfs*2 | P40394 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ADH7 | SNV | Missense_Mutation | rs759568380 | c.172C>T | p.Arg58Cys | p.R58C | P40394 | protein_coding | deleterious(0.04) | possibly_damaging(0.606) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ADH7 | SNV | Missense_Mutation | c.472N>A | p.His158Asn | p.H158N | P40394 | protein_coding | deleterious(0.04) | benign(0.04) | TCGA-EA-A3QE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ADH7 | SNV | Missense_Mutation | c.170N>G | p.Val57Gly | p.V57G | P40394 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ADH7 | SNV | Missense_Mutation | rs760167786 | c.893N>T | p.Ala298Val | p.A298V | P40394 | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADH7 | SNV | Missense_Mutation | rs147020637 | c.374N>A | p.Arg125His | p.R125H | P40394 | protein_coding | tolerated(0.44) | benign(0.013) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADH7 | SNV | Missense_Mutation | rs147020637 | c.374N>A | p.Arg125His | p.R125H | P40394 | protein_coding | tolerated(0.44) | benign(0.013) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
131 | ADH7 | DRUGGABLE GENOME, ENZYME | anthracyclines and related substances | 23441093,21900104 |
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