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Gene: ABCB8 |
Gene summary for ABCB8 |
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Gene information | Species | Human | Gene symbol | ABCB8 | Gene ID | 11194 |
Gene name | ATP binding cassette subfamily B member 8 | |
Gene Alias | EST328128 | |
Cytomap | 7q36.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NUT2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11194 | ABCB8 | P56T-E | Human | Esophagus | ESCC | 1.61e-05 | 6.24e-01 | 0.1613 |
11194 | ABCB8 | P57T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.61e-01 | 0.0926 |
11194 | ABCB8 | P61T-E | Human | Esophagus | ESCC | 6.73e-17 | 3.48e-01 | 0.099 |
11194 | ABCB8 | P62T-E | Human | Esophagus | ESCC | 8.45e-14 | 2.94e-01 | 0.1302 |
11194 | ABCB8 | P65T-E | Human | Esophagus | ESCC | 5.62e-18 | 3.73e-01 | 0.0978 |
11194 | ABCB8 | P74T-E | Human | Esophagus | ESCC | 3.12e-25 | 5.56e-01 | 0.1479 |
11194 | ABCB8 | P75T-E | Human | Esophagus | ESCC | 2.39e-24 | 4.09e-01 | 0.1125 |
11194 | ABCB8 | P76T-E | Human | Esophagus | ESCC | 1.97e-10 | 1.76e-01 | 0.1207 |
11194 | ABCB8 | P79T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.26e-01 | 0.1154 |
11194 | ABCB8 | P80T-E | Human | Esophagus | ESCC | 1.48e-19 | 5.80e-01 | 0.155 |
11194 | ABCB8 | P82T-E | Human | Esophagus | ESCC | 3.67e-14 | 5.49e-01 | 0.1072 |
11194 | ABCB8 | P83T-E | Human | Esophagus | ESCC | 1.41e-25 | 6.33e-01 | 0.1738 |
11194 | ABCB8 | P84T-E | Human | Esophagus | ESCC | 1.81e-05 | 2.98e-01 | 0.0933 |
11194 | ABCB8 | P89T-E | Human | Esophagus | ESCC | 1.03e-11 | 7.23e-01 | 0.1752 |
11194 | ABCB8 | P91T-E | Human | Esophagus | ESCC | 6.01e-17 | 1.41e+00 | 0.1828 |
11194 | ABCB8 | P94T-E | Human | Esophagus | ESCC | 2.58e-06 | 8.49e-01 | 0.0879 |
11194 | ABCB8 | P104T-E | Human | Esophagus | ESCC | 4.26e-13 | 5.49e-01 | 0.0931 |
11194 | ABCB8 | P107T-E | Human | Esophagus | ESCC | 4.22e-20 | 3.86e-01 | 0.171 |
11194 | ABCB8 | P126T-E | Human | Esophagus | ESCC | 4.26e-02 | 4.11e-01 | 0.1125 |
11194 | ABCB8 | P127T-E | Human | Esophagus | ESCC | 5.05e-07 | 8.02e-02 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa020102 | Liver | HCC | ABC transporters | 29/4020 | 45/8465 | 1.62e-02 | 3.88e-02 | 2.16e-02 | 29 |
hsa020103 | Liver | HCC | ABC transporters | 29/4020 | 45/8465 | 1.62e-02 | 3.88e-02 | 2.16e-02 | 29 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABCB8 | SNV | Missense_Mutation | rs772895911 | c.1310G>A | p.Arg437Gln | p.R437Q | Q9NUT2 | protein_coding | deleterious(0.02) | probably_damaging(0.941) | TCGA-A2-A0CO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
ABCB8 | SNV | Missense_Mutation | c.2064N>T | p.Trp688Cys | p.W688C | Q9NUT2 | protein_coding | tolerated(0.27) | benign(0) | TCGA-A7-A13F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ABCB8 | SNV | Missense_Mutation | rs374885136 | c.1100G>A | p.Arg367Gln | p.R367Q | Q9NUT2 | protein_coding | tolerated(0.14) | benign(0) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABCB8 | SNV | Missense_Mutation | c.1735N>A | p.Glu579Lys | p.E579K | Q9NUT2 | protein_coding | tolerated(0.14) | benign(0.292) | TCGA-AR-A24Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ABCB8 | SNV | Missense_Mutation | c.748C>A | p.Gln250Lys | p.Q250K | Q9NUT2 | protein_coding | tolerated(0.06) | benign(0.115) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ABCB8 | SNV | Missense_Mutation | novel | c.19C>G | p.Arg7Gly | p.R7G | Q9NUT2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.995) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
ABCB8 | SNV | Missense_Mutation | rs142475735 | c.997G>A | p.Val333Ile | p.V333I | Q9NUT2 | protein_coding | tolerated(0.09) | possibly_damaging(0.692) | TCGA-D8-A1JT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ABCB8 | SNV | Missense_Mutation | c.867N>T | p.Met289Ile | p.M289I | Q9NUT2 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABCB8 | SNV | Missense_Mutation | rs756291701 | c.298G>A | p.Val100Ile | p.V100I | Q9NUT2 | protein_coding | tolerated_low_confidence(0.37) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ABCB8 | SNV | Missense_Mutation | novel | c.1539N>T | p.Lys513Asn | p.K513N | Q9NUT2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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