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Gene: ZXDC |
Gene summary for ZXDC |
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Gene information | Species | Human | Gene symbol | ZXDC | Gene ID | 79364 |
Gene name | ZXD family zinc finger C | |
Gene Alias | ZXDL | |
Cytomap | 3q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q2QGD7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79364 | ZXDC | P27T-E | Human | Esophagus | ESCC | 2.11e-21 | 2.35e-01 | 0.1055 |
79364 | ZXDC | P28T-E | Human | Esophagus | ESCC | 1.55e-24 | 4.14e-01 | 0.1149 |
79364 | ZXDC | P30T-E | Human | Esophagus | ESCC | 5.72e-14 | 5.26e-01 | 0.137 |
79364 | ZXDC | P31T-E | Human | Esophagus | ESCC | 3.69e-22 | 1.81e-01 | 0.1251 |
79364 | ZXDC | P32T-E | Human | Esophagus | ESCC | 5.82e-05 | 8.47e-02 | 0.1666 |
79364 | ZXDC | P36T-E | Human | Esophagus | ESCC | 6.38e-04 | 2.05e-01 | 0.1187 |
79364 | ZXDC | P37T-E | Human | Esophagus | ESCC | 8.81e-07 | 1.06e-01 | 0.1371 |
79364 | ZXDC | P39T-E | Human | Esophagus | ESCC | 6.66e-10 | 1.95e-01 | 0.0894 |
79364 | ZXDC | P42T-E | Human | Esophagus | ESCC | 1.89e-08 | 2.51e-01 | 0.1175 |
79364 | ZXDC | P47T-E | Human | Esophagus | ESCC | 6.88e-07 | 1.72e-01 | 0.1067 |
79364 | ZXDC | P48T-E | Human | Esophagus | ESCC | 5.62e-08 | 1.95e-01 | 0.0959 |
79364 | ZXDC | P49T-E | Human | Esophagus | ESCC | 2.28e-03 | 3.53e-01 | 0.1768 |
79364 | ZXDC | P52T-E | Human | Esophagus | ESCC | 5.74e-14 | 2.57e-01 | 0.1555 |
79364 | ZXDC | P54T-E | Human | Esophagus | ESCC | 6.00e-08 | 2.52e-01 | 0.0975 |
79364 | ZXDC | P56T-E | Human | Esophagus | ESCC | 1.38e-09 | 5.08e-01 | 0.1613 |
79364 | ZXDC | P57T-E | Human | Esophagus | ESCC | 1.76e-02 | 9.64e-02 | 0.0926 |
79364 | ZXDC | P61T-E | Human | Esophagus | ESCC | 7.45e-11 | 2.74e-01 | 0.099 |
79364 | ZXDC | P62T-E | Human | Esophagus | ESCC | 3.63e-13 | 2.57e-01 | 0.1302 |
79364 | ZXDC | P65T-E | Human | Esophagus | ESCC | 1.64e-12 | 2.99e-01 | 0.0978 |
79364 | ZXDC | P74T-E | Human | Esophagus | ESCC | 4.64e-11 | 3.26e-01 | 0.1479 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZXDC | SNV | Missense_Mutation | rs758081002 | c.2426N>T | p.Ser809Leu | p.S809L | Q2QGD7 | protein_coding | tolerated(1) | benign(0) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
ZXDC | SNV | Missense_Mutation | novel | c.905C>G | p.Pro302Arg | p.P302R | Q2QGD7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZXDC | SNV | Missense_Mutation | novel | c.1069N>T | p.Pro357Ser | p.P357S | Q2QGD7 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZXDC | SNV | Missense_Mutation | c.1870N>A | p.Pro624Thr | p.P624T | Q2QGD7 | protein_coding | tolerated(0.08) | benign(0.072) | TCGA-AO-A12F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
ZXDC | SNV | Missense_Mutation | c.2271N>G | p.Phe757Leu | p.F757L | Q2QGD7 | protein_coding | tolerated(0.74) | benign(0) | TCGA-B6-A1KC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZXDC | insertion | Frame_Shift_Ins | novel | c.1069_1070insATTT | p.Pro357HisfsTer6 | p.P357Hfs*6 | Q2QGD7 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZXDC | deletion | Frame_Shift_Del | novel | c.2138delN | p.Gly713AlafsTer12 | p.G713Afs*12 | Q2QGD7 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZXDC | SNV | Missense_Mutation | rs750723904 | c.1414A>G | p.Met472Val | p.M472V | Q2QGD7 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZXDC | SNV | Missense_Mutation | novel | c.752N>A | p.Thr251Lys | p.T251K | Q2QGD7 | protein_coding | deleterious(0.01) | possibly_damaging(0.883) | TCGA-EK-A2RE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZXDC | SNV | Missense_Mutation | novel | c.2161G>T | p.Ala721Ser | p.A721S | Q2QGD7 | protein_coding | tolerated(0.07) | benign(0.352) | TCGA-VS-A8EJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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