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Gene: ZNF92 |
Gene summary for ZNF92 |
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Gene information | Species | Human | Gene symbol | ZNF92 | Gene ID | 168374 |
Gene name | zinc finger protein 92 | |
Gene Alias | HEL-203 | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q03936 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
168374 | ZNF92 | P23T-E | Human | Esophagus | ESCC | 2.64e-09 | 1.70e-01 | 0.108 |
168374 | ZNF92 | P24T-E | Human | Esophagus | ESCC | 6.03e-04 | 1.06e-01 | 0.1287 |
168374 | ZNF92 | P26T-E | Human | Esophagus | ESCC | 3.66e-18 | 3.40e-01 | 0.1276 |
168374 | ZNF92 | P27T-E | Human | Esophagus | ESCC | 3.98e-12 | 2.09e-01 | 0.1055 |
168374 | ZNF92 | P28T-E | Human | Esophagus | ESCC | 1.13e-10 | 2.48e-01 | 0.1149 |
168374 | ZNF92 | P30T-E | Human | Esophagus | ESCC | 9.34e-03 | 1.59e-01 | 0.137 |
168374 | ZNF92 | P31T-E | Human | Esophagus | ESCC | 1.40e-05 | 1.69e-01 | 0.1251 |
168374 | ZNF92 | P32T-E | Human | Esophagus | ESCC | 1.17e-03 | 2.25e-01 | 0.1666 |
168374 | ZNF92 | P36T-E | Human | Esophagus | ESCC | 2.76e-06 | 2.30e-01 | 0.1187 |
168374 | ZNF92 | P37T-E | Human | Esophagus | ESCC | 3.49e-07 | 1.60e-01 | 0.1371 |
168374 | ZNF92 | P40T-E | Human | Esophagus | ESCC | 3.14e-04 | 1.69e-01 | 0.109 |
168374 | ZNF92 | P42T-E | Human | Esophagus | ESCC | 8.21e-11 | 2.07e-01 | 0.1175 |
168374 | ZNF92 | P44T-E | Human | Esophagus | ESCC | 8.73e-05 | 1.21e-01 | 0.1096 |
168374 | ZNF92 | P47T-E | Human | Esophagus | ESCC | 3.97e-10 | 1.95e-01 | 0.1067 |
168374 | ZNF92 | P48T-E | Human | Esophagus | ESCC | 2.84e-04 | 9.94e-02 | 0.0959 |
168374 | ZNF92 | P49T-E | Human | Esophagus | ESCC | 2.58e-06 | 3.32e-01 | 0.1768 |
168374 | ZNF92 | P52T-E | Human | Esophagus | ESCC | 3.60e-08 | 2.12e-01 | 0.1555 |
168374 | ZNF92 | P54T-E | Human | Esophagus | ESCC | 3.56e-08 | 1.73e-01 | 0.0975 |
168374 | ZNF92 | P56T-E | Human | Esophagus | ESCC | 7.34e-06 | 4.49e-01 | 0.1613 |
168374 | ZNF92 | P57T-E | Human | Esophagus | ESCC | 2.34e-05 | 9.03e-02 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF92 | SNV | Missense_Mutation | c.1166N>C | p.Arg389Thr | p.R389T | Q03936 | protein_coding | tolerated(0.15) | possibly_damaging(0.647) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF92 | SNV | Missense_Mutation | novel | c.353A>C | p.Lys118Thr | p.K118T | Q03936 | protein_coding | tolerated(0.1) | benign(0.077) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF92 | SNV | Missense_Mutation | c.1628N>G | p.Asp543Gly | p.D543G | Q03936 | protein_coding | tolerated(1) | benign(0.003) | TCGA-C5-A1BI-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ZNF92 | SNV | Missense_Mutation | rs377733062 | c.463N>T | p.His155Tyr | p.H155Y | Q03936 | protein_coding | tolerated(0.25) | benign(0.026) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF92 | SNV | Missense_Mutation | c.341G>A | p.Arg114Lys | p.R114K | Q03936 | protein_coding | tolerated(0.45) | benign(0.013) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF92 | SNV | Missense_Mutation | c.277N>T | p.Asp93Tyr | p.D93Y | Q03936 | protein_coding | deleterious(0.04) | benign(0.062) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF92 | SNV | Missense_Mutation | rs781442558 | c.1423N>A | p.His475Asn | p.H475N | Q03936 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF92 | SNV | Missense_Mutation | novel | c.579N>C | p.Lys193Asn | p.K193N | Q03936 | protein_coding | tolerated(0.08) | benign(0.348) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF92 | SNV | Missense_Mutation | novel | c.1059N>A | p.Phe353Leu | p.F353L | Q03936 | protein_coding | tolerated(0.43) | benign(0.013) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF92 | SNV | Missense_Mutation | novel | c.467N>C | p.Lys156Thr | p.K156T | Q03936 | protein_coding | deleterious(0.03) | benign(0.117) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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