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Gene: ZNF770 |
Gene summary for ZNF770 |
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Gene information | Species | Human | Gene symbol | ZNF770 | Gene ID | 54989 |
Gene name | zinc finger protein 770 | |
Gene Alias | PRO1914 | |
Cytomap | 15q14 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6IQ21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54989 | ZNF770 | P21T-E | Human | Esophagus | ESCC | 8.45e-22 | 2.93e-01 | 0.1617 |
54989 | ZNF770 | P22T-E | Human | Esophagus | ESCC | 1.95e-11 | 1.84e-01 | 0.1236 |
54989 | ZNF770 | P23T-E | Human | Esophagus | ESCC | 8.63e-19 | 3.98e-01 | 0.108 |
54989 | ZNF770 | P24T-E | Human | Esophagus | ESCC | 6.59e-13 | 2.21e-01 | 0.1287 |
54989 | ZNF770 | P26T-E | Human | Esophagus | ESCC | 1.95e-33 | 5.72e-01 | 0.1276 |
54989 | ZNF770 | P27T-E | Human | Esophagus | ESCC | 2.55e-17 | 2.78e-01 | 0.1055 |
54989 | ZNF770 | P28T-E | Human | Esophagus | ESCC | 2.04e-21 | 3.76e-01 | 0.1149 |
54989 | ZNF770 | P30T-E | Human | Esophagus | ESCC | 1.36e-22 | 1.13e+00 | 0.137 |
54989 | ZNF770 | P31T-E | Human | Esophagus | ESCC | 6.23e-17 | 1.87e-01 | 0.1251 |
54989 | ZNF770 | P32T-E | Human | Esophagus | ESCC | 4.99e-19 | 2.77e-01 | 0.1666 |
54989 | ZNF770 | P36T-E | Human | Esophagus | ESCC | 6.18e-09 | 3.42e-01 | 0.1187 |
54989 | ZNF770 | P37T-E | Human | Esophagus | ESCC | 3.05e-21 | 2.11e-01 | 0.1371 |
54989 | ZNF770 | P38T-E | Human | Esophagus | ESCC | 5.98e-03 | 7.22e-02 | 0.127 |
54989 | ZNF770 | P39T-E | Human | Esophagus | ESCC | 2.75e-10 | 1.47e-01 | 0.0894 |
54989 | ZNF770 | P40T-E | Human | Esophagus | ESCC | 6.89e-10 | 6.01e-02 | 0.109 |
54989 | ZNF770 | P42T-E | Human | Esophagus | ESCC | 5.75e-08 | 2.39e-01 | 0.1175 |
54989 | ZNF770 | P44T-E | Human | Esophagus | ESCC | 1.18e-17 | 1.65e-01 | 0.1096 |
54989 | ZNF770 | P47T-E | Human | Esophagus | ESCC | 7.58e-19 | 1.04e-01 | 0.1067 |
54989 | ZNF770 | P48T-E | Human | Esophagus | ESCC | 1.22e-14 | 1.77e-01 | 0.0959 |
54989 | ZNF770 | P49T-E | Human | Esophagus | ESCC | 2.61e-09 | 9.32e-01 | 0.1768 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF770 | SNV | Missense_Mutation | novel | c.73A>T | p.Arg25Trp | p.R25W | Q6IQ21 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-A7-A6VW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
ZNF770 | SNV | Missense_Mutation | novel | c.2023N>T | p.His675Tyr | p.H675Y | Q6IQ21 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A3W7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
ZNF770 | SNV | Missense_Mutation | rs140429599 | c.1618G>C | p.Gly540Arg | p.G540R | Q6IQ21 | protein_coding | tolerated(0.1) | benign(0.125) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF770 | SNV | Missense_Mutation | novel | c.322C>G | p.Gln108Glu | p.Q108E | Q6IQ21 | protein_coding | tolerated(0.24) | benign(0.084) | TCGA-AQ-A7U7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | rituximab | CR |
ZNF770 | SNV | Missense_Mutation | rs768441646 | c.1877N>A | p.Arg626Gln | p.R626Q | Q6IQ21 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF770 | SNV | Missense_Mutation | novel | c.470N>C | p.Lys157Thr | p.K157T | Q6IQ21 | protein_coding | deleterious(0.01) | possibly_damaging(0.835) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF770 | SNV | Missense_Mutation | novel | c.1610N>C | p.Val537Ala | p.V537A | Q6IQ21 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-ZJ-AAXA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF770 | SNV | Missense_Mutation | c.1981N>G | p.Thr661Ala | p.T661A | Q6IQ21 | protein_coding | deleterious(0.01) | benign(0.056) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
ZNF770 | SNV | Missense_Mutation | c.1528N>G | p.Lys510Glu | p.K510E | Q6IQ21 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF770 | SNV | Missense_Mutation | novel | c.1321N>C | p.Ser441Pro | p.S441P | Q6IQ21 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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