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Gene: ZNF766 |
Gene summary for ZNF766 |
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Gene information | Species | Human | Gene symbol | ZNF766 | Gene ID | 90321 |
Gene name | zinc finger protein 766 | |
Gene Alias | ZNF766 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5HY98 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90321 | ZNF766 | P26T-E | Human | Esophagus | ESCC | 1.21e-17 | 3.54e-01 | 0.1276 |
90321 | ZNF766 | P27T-E | Human | Esophagus | ESCC | 2.56e-09 | 3.05e-01 | 0.1055 |
90321 | ZNF766 | P28T-E | Human | Esophagus | ESCC | 3.70e-08 | 1.83e-01 | 0.1149 |
90321 | ZNF766 | P30T-E | Human | Esophagus | ESCC | 4.79e-09 | 4.47e-01 | 0.137 |
90321 | ZNF766 | P31T-E | Human | Esophagus | ESCC | 1.72e-09 | 2.44e-01 | 0.1251 |
90321 | ZNF766 | P32T-E | Human | Esophagus | ESCC | 5.17e-13 | 2.29e-01 | 0.1666 |
90321 | ZNF766 | P36T-E | Human | Esophagus | ESCC | 2.30e-11 | 2.67e-01 | 0.1187 |
90321 | ZNF766 | P37T-E | Human | Esophagus | ESCC | 1.55e-07 | 1.69e-01 | 0.1371 |
90321 | ZNF766 | P39T-E | Human | Esophagus | ESCC | 9.27e-12 | 1.58e-01 | 0.0894 |
90321 | ZNF766 | P42T-E | Human | Esophagus | ESCC | 2.98e-02 | 1.43e-01 | 0.1175 |
90321 | ZNF766 | P44T-E | Human | Esophagus | ESCC | 2.09e-03 | 1.22e-01 | 0.1096 |
90321 | ZNF766 | P47T-E | Human | Esophagus | ESCC | 5.02e-06 | 8.90e-02 | 0.1067 |
90321 | ZNF766 | P48T-E | Human | Esophagus | ESCC | 3.45e-07 | 1.37e-01 | 0.0959 |
90321 | ZNF766 | P49T-E | Human | Esophagus | ESCC | 3.38e-04 | 4.09e-01 | 0.1768 |
90321 | ZNF766 | P52T-E | Human | Esophagus | ESCC | 3.38e-05 | 2.02e-01 | 0.1555 |
90321 | ZNF766 | P54T-E | Human | Esophagus | ESCC | 2.80e-10 | 3.63e-01 | 0.0975 |
90321 | ZNF766 | P57T-E | Human | Esophagus | ESCC | 7.03e-06 | 1.35e-01 | 0.0926 |
90321 | ZNF766 | P61T-E | Human | Esophagus | ESCC | 3.56e-07 | 2.34e-01 | 0.099 |
90321 | ZNF766 | P62T-E | Human | Esophagus | ESCC | 7.17e-23 | 4.02e-01 | 0.1302 |
90321 | ZNF766 | P65T-E | Human | Esophagus | ESCC | 6.74e-09 | 1.68e-01 | 0.0978 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF766 | SNV | Missense_Mutation | rs375042302 | c.440N>T | p.Ser147Leu | p.S147L | Q5HY98 | protein_coding | tolerated(0.13) | benign(0.011) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD |
ZNF766 | SNV | Missense_Mutation | novel | c.935C>T | p.Ser312Leu | p.S312L | Q5HY98 | protein_coding | deleterious(0.01) | possibly_damaging(0.48) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF766 | SNV | Missense_Mutation | novel | c.1196N>T | p.Ala399Val | p.A399V | Q5HY98 | protein_coding | tolerated(0.26) | benign(0.017) | TCGA-VS-A8QH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | gemcitabine | PD |
ZNF766 | insertion | Frame_Shift_Ins | novel | c.933_934insGTGGA | p.Ser312ValfsTer5 | p.S312Vfs*5 | Q5HY98 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
ZNF766 | SNV | Missense_Mutation | c.956N>T | p.Arg319Ile | p.R319I | Q5HY98 | protein_coding | tolerated(0.11) | possibly_damaging(0.544) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF766 | SNV | Missense_Mutation | c.1359N>C | p.Trp453Cys | p.W453C | Q5HY98 | protein_coding | tolerated(0.16) | benign(0) | TCGA-CM-6168-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF766 | SNV | Missense_Mutation | c.961N>T | p.His321Tyr | p.H321Y | Q5HY98 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-F4-6460-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD | |
ZNF766 | SNV | Missense_Mutation | rs752315701 | c.40N>A | p.Val14Met | p.V14M | Q5HY98 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF766 | SNV | Missense_Mutation | c.972N>T | p.Glu324Asp | p.E324D | Q5HY98 | protein_coding | deleterious(0.02) | possibly_damaging(0.813) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF766 | SNV | Missense_Mutation | rs766094251 | c.845G>A | p.Arg282Gln | p.R282Q | Q5HY98 | protein_coding | tolerated(1) | benign(0.007) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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