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Gene: ZNF704 |
Gene summary for ZNF704 |
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Gene information | Species | Human | Gene symbol | ZNF704 | Gene ID | 619279 |
Gene name | zinc finger protein 704 | |
Gene Alias | Gig1 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZNC4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
619279 | ZNF704 | A015-C-204 | Human | Colorectum | FAP | 1.48e-08 | -3.88e-01 | -0.0228 |
619279 | ZNF704 | A014-C-040 | Human | Colorectum | FAP | 2.52e-05 | -4.74e-01 | -0.1184 |
619279 | ZNF704 | A002-C-201 | Human | Colorectum | FAP | 2.03e-20 | -4.96e-01 | 0.0324 |
619279 | ZNF704 | A001-C-119 | Human | Colorectum | FAP | 6.03e-10 | -4.81e-01 | -0.1557 |
619279 | ZNF704 | A001-C-108 | Human | Colorectum | FAP | 1.58e-15 | -3.25e-01 | -0.0272 |
619279 | ZNF704 | A002-C-205 | Human | Colorectum | FAP | 3.14e-27 | -4.88e-01 | -0.1236 |
619279 | ZNF704 | A001-C-104 | Human | Colorectum | FAP | 1.74e-03 | -2.82e-01 | 0.0184 |
619279 | ZNF704 | A015-C-005 | Human | Colorectum | FAP | 3.79e-04 | -2.00e-01 | -0.0336 |
619279 | ZNF704 | A015-C-006 | Human | Colorectum | FAP | 6.10e-22 | -6.03e-01 | -0.0994 |
619279 | ZNF704 | A015-C-106 | Human | Colorectum | FAP | 1.98e-09 | -2.43e-01 | -0.0511 |
619279 | ZNF704 | A002-C-114 | Human | Colorectum | FAP | 1.36e-24 | -5.10e-01 | -0.1561 |
619279 | ZNF704 | A015-C-104 | Human | Colorectum | FAP | 2.34e-28 | -3.77e-01 | -0.1899 |
619279 | ZNF704 | A001-C-014 | Human | Colorectum | FAP | 3.19e-12 | -3.22e-01 | 0.0135 |
619279 | ZNF704 | A002-C-016 | Human | Colorectum | FAP | 9.65e-28 | -5.20e-01 | 0.0521 |
619279 | ZNF704 | A015-C-002 | Human | Colorectum | FAP | 9.29e-20 | -6.21e-01 | -0.0763 |
619279 | ZNF704 | A001-C-203 | Human | Colorectum | FAP | 1.99e-07 | -1.50e-01 | -0.0481 |
619279 | ZNF704 | A002-C-116 | Human | Colorectum | FAP | 7.44e-39 | -7.04e-01 | -0.0452 |
619279 | ZNF704 | A014-C-008 | Human | Colorectum | FAP | 9.44e-17 | -4.03e-01 | -0.191 |
619279 | ZNF704 | A018-E-020 | Human | Colorectum | FAP | 5.44e-24 | -4.61e-01 | -0.2034 |
619279 | ZNF704 | F034 | Human | Colorectum | FAP | 5.55e-16 | -3.07e-01 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF704 | SNV | Missense_Mutation | rs752885224 | c.1157G>A | p.Arg386Gln | p.R386Q | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
ZNF704 | SNV | Missense_Mutation | novel | c.119N>T | p.Ala40Val | p.A40V | Q6ZNC4 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF704 | insertion | Nonsense_Mutation | novel | c.733_734insAAATAAAATGTAAGCATTGGAAAGCTTTGGCA | p.Ser245Ter | p.S245* | Q6ZNC4 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
ZNF704 | SNV | Missense_Mutation | c.1063N>A | p.Gly355Arg | p.G355R | Q6ZNC4 | protein_coding | tolerated(0.28) | probably_damaging(0.911) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF704 | SNV | Missense_Mutation | c.824N>A | p.Arg275Gln | p.R275Q | Q6ZNC4 | protein_coding | tolerated(0.34) | benign(0.014) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF704 | SNV | Missense_Mutation | c.1040N>T | p.Pro347Leu | p.P347L | Q6ZNC4 | protein_coding | tolerated(0.14) | probably_damaging(0.998) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF704 | SNV | Missense_Mutation | novel | c.46N>C | p.Lys16Gln | p.K16Q | Q6ZNC4 | protein_coding | tolerated_low_confidence(0.52) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF704 | SNV | Missense_Mutation | rs139476385 | c.1052C>T | p.Pro351Leu | p.P351L | Q6ZNC4 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-CM-6161-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF704 | SNV | Missense_Mutation | rs752885224 | c.1157G>A | p.Arg386Gln | p.R386Q | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF704 | SNV | Missense_Mutation | c.980N>A | p.Ser327Asn | p.S327N | Q6ZNC4 | protein_coding | tolerated(0.58) | benign(0.003) | TCGA-G4-6294-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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