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Gene: ZNF623 |
Gene summary for ZNF623 |
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Gene information | Species | Human | Gene symbol | ZNF623 | Gene ID | 9831 |
Gene name | zinc finger protein 623 | |
Gene Alias | ZNF623 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0A0MT18 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9831 | ZNF623 | P28T-E | Human | Esophagus | ESCC | 3.79e-10 | 2.12e-01 | 0.1149 |
9831 | ZNF623 | P30T-E | Human | Esophagus | ESCC | 1.84e-12 | 3.93e-01 | 0.137 |
9831 | ZNF623 | P31T-E | Human | Esophagus | ESCC | 1.60e-25 | 2.92e-01 | 0.1251 |
9831 | ZNF623 | P32T-E | Human | Esophagus | ESCC | 3.27e-14 | 2.42e-01 | 0.1666 |
9831 | ZNF623 | P36T-E | Human | Esophagus | ESCC | 2.63e-16 | 4.39e-01 | 0.1187 |
9831 | ZNF623 | P37T-E | Human | Esophagus | ESCC | 4.16e-02 | 6.95e-02 | 0.1371 |
9831 | ZNF623 | P39T-E | Human | Esophagus | ESCC | 4.62e-10 | 1.61e-01 | 0.0894 |
9831 | ZNF623 | P40T-E | Human | Esophagus | ESCC | 6.83e-03 | 1.39e-01 | 0.109 |
9831 | ZNF623 | P42T-E | Human | Esophagus | ESCC | 3.32e-06 | 2.17e-01 | 0.1175 |
9831 | ZNF623 | P44T-E | Human | Esophagus | ESCC | 6.15e-03 | 1.14e-01 | 0.1096 |
9831 | ZNF623 | P47T-E | Human | Esophagus | ESCC | 2.06e-10 | 1.08e-01 | 0.1067 |
9831 | ZNF623 | P48T-E | Human | Esophagus | ESCC | 6.23e-11 | 1.23e-01 | 0.0959 |
9831 | ZNF623 | P49T-E | Human | Esophagus | ESCC | 5.83e-13 | 6.15e-01 | 0.1768 |
9831 | ZNF623 | P52T-E | Human | Esophagus | ESCC | 1.04e-11 | 2.80e-01 | 0.1555 |
9831 | ZNF623 | P54T-E | Human | Esophagus | ESCC | 4.06e-08 | 2.47e-01 | 0.0975 |
9831 | ZNF623 | P56T-E | Human | Esophagus | ESCC | 1.59e-03 | 2.99e-01 | 0.1613 |
9831 | ZNF623 | P57T-E | Human | Esophagus | ESCC | 2.14e-04 | 2.02e-01 | 0.0926 |
9831 | ZNF623 | P61T-E | Human | Esophagus | ESCC | 1.30e-05 | 1.45e-01 | 0.099 |
9831 | ZNF623 | P62T-E | Human | Esophagus | ESCC | 7.39e-26 | 4.31e-01 | 0.1302 |
9831 | ZNF623 | P65T-E | Human | Esophagus | ESCC | 2.98e-09 | 2.03e-01 | 0.0978 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF623 | SNV | Missense_Mutation | novel | c.1266N>T | p.Gln422His | p.Q422H | O75123 | protein_coding | deleterious(0.04) | possibly_damaging(0.888) | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
ZNF623 | SNV | Missense_Mutation | novel | c.950G>A | p.Arg317Lys | p.R317K | O75123 | protein_coding | tolerated(1) | benign(0.365) | TCGA-AC-A5XU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
ZNF623 | SNV | Missense_Mutation | c.910T>C | p.Ser304Pro | p.S304P | O75123 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-AR-A24N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF623 | SNV | Missense_Mutation | c.283N>G | p.Gln95Glu | p.Q95E | O75123 | protein_coding | tolerated(0.05) | benign(0.013) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF623 | SNV | Missense_Mutation | c.1130G>A | p.Cys377Tyr | p.C377Y | O75123 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EW-A1P7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
ZNF623 | SNV | Missense_Mutation | novel | c.112N>T | p.Leu38Phe | p.L38F | O75123 | protein_coding | tolerated(0.09) | benign(0.044) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF623 | SNV | Missense_Mutation | rs373149668 | c.857C>T | p.Thr286Ile | p.T286I | O75123 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-Q1-A6DT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF623 | SNV | Missense_Mutation | rs375460182 | c.398N>T | p.Thr133Met | p.T133M | O75123 | protein_coding | tolerated(0.09) | possibly_damaging(0.582) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZNF623 | SNV | Missense_Mutation | rs370100274 | c.488N>A | p.Ser163Asn | p.S163N | O75123 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF623 | SNV | Missense_Mutation | c.1175N>A | p.Arg392Gln | p.R392Q | O75123 | protein_coding | tolerated(0.64) | probably_damaging(0.999) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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