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Gene: ZNF343 |
Gene summary for ZNF343 |
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Gene information | Species | Human | Gene symbol | ZNF343 | Gene ID | 79175 |
Gene name | zinc finger protein 343 | |
Gene Alias | dJ734P14.5 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q6P1L6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79175 | ZNF343 | P32T-E | Human | Esophagus | ESCC | 1.60e-05 | 1.08e-01 | 0.1666 |
79175 | ZNF343 | P36T-E | Human | Esophagus | ESCC | 1.12e-05 | 2.03e-01 | 0.1187 |
79175 | ZNF343 | P47T-E | Human | Esophagus | ESCC | 8.14e-13 | 8.85e-02 | 0.1067 |
79175 | ZNF343 | P48T-E | Human | Esophagus | ESCC | 7.12e-10 | 6.69e-02 | 0.0959 |
79175 | ZNF343 | P49T-E | Human | Esophagus | ESCC | 7.48e-03 | 2.02e-01 | 0.1768 |
79175 | ZNF343 | P52T-E | Human | Esophagus | ESCC | 1.03e-05 | 9.96e-02 | 0.1555 |
79175 | ZNF343 | P54T-E | Human | Esophagus | ESCC | 9.92e-04 | 1.01e-01 | 0.0975 |
79175 | ZNF343 | P57T-E | Human | Esophagus | ESCC | 1.41e-04 | 5.36e-02 | 0.0926 |
79175 | ZNF343 | P61T-E | Human | Esophagus | ESCC | 1.48e-02 | 7.69e-02 | 0.099 |
79175 | ZNF343 | P62T-E | Human | Esophagus | ESCC | 2.60e-03 | 9.05e-02 | 0.1302 |
79175 | ZNF343 | P65T-E | Human | Esophagus | ESCC | 1.06e-02 | 8.01e-02 | 0.0978 |
79175 | ZNF343 | P74T-E | Human | Esophagus | ESCC | 7.24e-03 | 1.04e-01 | 0.1479 |
79175 | ZNF343 | P75T-E | Human | Esophagus | ESCC | 1.62e-09 | 9.47e-02 | 0.1125 |
79175 | ZNF343 | P79T-E | Human | Esophagus | ESCC | 9.88e-13 | 8.87e-02 | 0.1154 |
79175 | ZNF343 | P80T-E | Human | Esophagus | ESCC | 1.97e-04 | 1.82e-01 | 0.155 |
79175 | ZNF343 | P83T-E | Human | Esophagus | ESCC | 2.39e-19 | 4.27e-01 | 0.1738 |
79175 | ZNF343 | P89T-E | Human | Esophagus | ESCC | 3.85e-03 | 2.58e-01 | 0.1752 |
79175 | ZNF343 | P107T-E | Human | Esophagus | ESCC | 2.64e-07 | 1.49e-01 | 0.171 |
79175 | ZNF343 | P128T-E | Human | Esophagus | ESCC | 1.60e-13 | 3.58e-01 | 0.1241 |
79175 | ZNF343 | P130T-E | Human | Esophagus | ESCC | 1.71e-04 | 4.30e-02 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF343 | SNV | Missense_Mutation | novel | c.1795T>A | p.Phe599Ile | p.F599I | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF343 | SNV | Missense_Mutation | c.295C>T | p.Leu99Phe | p.L99F | protein_coding | tolerated(0.13) | benign(0.272) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZNF343 | SNV | Missense_Mutation | c.1786G>A | p.Gly596Ser | p.G596S | protein_coding | deleterious(0) | possibly_damaging(0.814) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
ZNF343 | insertion | Frame_Shift_Ins | novel | c.1629_1630insGGGCCTCTTAGCTACTCCCC | p.Ser544GlyfsTer115 | p.S544Gfs*115 | protein_coding | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD | |||
ZNF343 | insertion | Frame_Shift_Ins | novel | c.1796_1797insC | p.Ser600Ter | p.S600* | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ZNF343 | insertion | Frame_Shift_Ins | novel | c.1793_1794insGAGAGGGGCAAAGATGT | p.Phe599ArgfsTer59 | p.F599Rfs*59 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ZNF343 | insertion | Frame_Shift_Ins | novel | c.1440_1441insG | p.Arg481GlufsTer9 | p.R481Efs*9 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | |||
ZNF343 | insertion | Nonsense_Mutation | novel | c.1439_1440insAAATTAGGTAAAGTGATTCAGATTAAAGGTGAAATAATTTATACA | p.Cys480delinsTer | p.C480delins* | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | |||
ZNF343 | SNV | Missense_Mutation | novel | c.213N>A | p.Phe71Leu | p.F71L | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
ZNF343 | SNV | Missense_Mutation | novel | c.143N>T | p.Cys48Phe | p.C48F | protein_coding | tolerated(0.09) | benign(0.029) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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