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Gene: ZNF250 |
Gene summary for ZNF250 |
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Gene information | Species | Human | Gene symbol | ZNF250 | Gene ID | 58500 |
Gene name | zinc finger protein 250 | |
Gene Alias | ZFP647 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KNS9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
58500 | ZNF250 | P27T-E | Human | Esophagus | ESCC | 1.36e-11 | 2.43e-01 | 0.1055 |
58500 | ZNF250 | P28T-E | Human | Esophagus | ESCC | 1.26e-05 | 1.42e-01 | 0.1149 |
58500 | ZNF250 | P30T-E | Human | Esophagus | ESCC | 8.03e-06 | 2.85e-01 | 0.137 |
58500 | ZNF250 | P31T-E | Human | Esophagus | ESCC | 1.40e-07 | 1.39e-01 | 0.1251 |
58500 | ZNF250 | P36T-E | Human | Esophagus | ESCC | 7.09e-12 | 2.06e-01 | 0.1187 |
58500 | ZNF250 | P44T-E | Human | Esophagus | ESCC | 2.53e-04 | 1.26e-01 | 0.1096 |
58500 | ZNF250 | P48T-E | Human | Esophagus | ESCC | 1.16e-05 | 1.30e-01 | 0.0959 |
58500 | ZNF250 | P49T-E | Human | Esophagus | ESCC | 2.40e-02 | 1.96e-01 | 0.1768 |
58500 | ZNF250 | P52T-E | Human | Esophagus | ESCC | 1.90e-07 | 1.54e-01 | 0.1555 |
58500 | ZNF250 | P54T-E | Human | Esophagus | ESCC | 6.16e-13 | 3.09e-01 | 0.0975 |
58500 | ZNF250 | P56T-E | Human | Esophagus | ESCC | 7.31e-04 | 3.53e-01 | 0.1613 |
58500 | ZNF250 | P57T-E | Human | Esophagus | ESCC | 4.69e-06 | 1.24e-01 | 0.0926 |
58500 | ZNF250 | P61T-E | Human | Esophagus | ESCC | 6.85e-03 | 1.00e-01 | 0.099 |
58500 | ZNF250 | P62T-E | Human | Esophagus | ESCC | 6.56e-11 | 1.87e-01 | 0.1302 |
58500 | ZNF250 | P65T-E | Human | Esophagus | ESCC | 3.81e-08 | 1.73e-01 | 0.0978 |
58500 | ZNF250 | P74T-E | Human | Esophagus | ESCC | 5.07e-10 | 2.64e-01 | 0.1479 |
58500 | ZNF250 | P75T-E | Human | Esophagus | ESCC | 1.15e-17 | 3.07e-01 | 0.1125 |
58500 | ZNF250 | P76T-E | Human | Esophagus | ESCC | 6.93e-06 | 1.27e-01 | 0.1207 |
58500 | ZNF250 | P79T-E | Human | Esophagus | ESCC | 8.13e-12 | 2.68e-01 | 0.1154 |
58500 | ZNF250 | P80T-E | Human | Esophagus | ESCC | 1.80e-11 | 2.71e-01 | 0.155 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF250 | SNV | Missense_Mutation | c.1508G>A | p.Gly503Asp | p.G503D | P15622 | protein_coding | deleterious(0) | possibly_damaging(0.822) | TCGA-A8-A0A9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
ZNF250 | SNV | Missense_Mutation | c.1572N>C | p.Gln524His | p.Q524H | P15622 | protein_coding | tolerated(0.16) | probably_damaging(0.979) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF250 | SNV | Missense_Mutation | rs561303501 | c.1624C>T | p.Arg542Cys | p.R542C | P15622 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
ZNF250 | SNV | Missense_Mutation | c.1195G>C | p.Glu399Gln | p.E399Q | P15622 | protein_coding | deleterious(0.02) | possibly_damaging(0.724) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF250 | SNV | Missense_Mutation | c.665N>A | p.Thr222Asn | p.T222N | P15622 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-E2-A1BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
ZNF250 | insertion | Nonsense_Mutation | novel | c.997_998insCCTTTATCTGGAGCTTTTAACTTTATTCAAGATCAGAAAGGATATGCT | p.His333delinsProPheIleTrpSerPheTerLeuTyrSerArgSerGluArgIleCysTyr | p.H333delinsPFIWSF*LYSRSERICY | P15622 | protein_coding | TCGA-A8-A06T-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
ZNF250 | insertion | Frame_Shift_Ins | novel | c.1328_1329insGTTCAAGCTTTTCTTGTGCCTCAGTCTCCCAAGT | p.Val444PhefsTer23 | p.V444Ffs*23 | P15622 | protein_coding | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF250 | insertion | In_Frame_Ins | novel | c.447_448insGTGAGTGTGGGA | p.Thr149_Pro150insValSerValGly | p.T149_P150insVSVG | P15622 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF250 | insertion | In_Frame_Ins | novel | c.445_446insGCCCTATGAGTG | p.Thr149delinsSerProMetSerAla | p.T149delinsSPMSA | P15622 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF250 | insertion | Nonsense_Mutation | novel | c.1253_1254insAAAGTCTTGCTCTTGTTCCCCAGGCTGAAG | p.Thr418_Glu419insLysSerCysSerCysSerProGlyTerSer | p.T418_E419insKSCSCSPG*S | P15622 | protein_coding | TCGA-A8-A09B-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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