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Gene: ZNF195 |
Gene summary for ZNF195 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF195 | Gene ID | 7748 |
Gene name | zinc finger protein 195 | |
Gene Alias | HRF1 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O14628 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7748 | ZNF195 | P22T-E | Human | Esophagus | ESCC | 1.44e-16 | 2.37e-01 | 0.1236 |
7748 | ZNF195 | P23T-E | Human | Esophagus | ESCC | 2.29e-10 | 3.13e-01 | 0.108 |
7748 | ZNF195 | P24T-E | Human | Esophagus | ESCC | 6.43e-09 | 1.51e-01 | 0.1287 |
7748 | ZNF195 | P26T-E | Human | Esophagus | ESCC | 1.89e-22 | 2.81e-01 | 0.1276 |
7748 | ZNF195 | P27T-E | Human | Esophagus | ESCC | 9.50e-12 | 2.96e-01 | 0.1055 |
7748 | ZNF195 | P28T-E | Human | Esophagus | ESCC | 7.96e-19 | 2.58e-01 | 0.1149 |
7748 | ZNF195 | P30T-E | Human | Esophagus | ESCC | 2.44e-05 | 1.47e-01 | 0.137 |
7748 | ZNF195 | P31T-E | Human | Esophagus | ESCC | 2.04e-19 | 1.19e-01 | 0.1251 |
7748 | ZNF195 | P32T-E | Human | Esophagus | ESCC | 5.64e-17 | 2.03e-01 | 0.1666 |
7748 | ZNF195 | P36T-E | Human | Esophagus | ESCC | 2.74e-07 | 2.14e-01 | 0.1187 |
7748 | ZNF195 | P37T-E | Human | Esophagus | ESCC | 2.25e-07 | 1.78e-01 | 0.1371 |
7748 | ZNF195 | P39T-E | Human | Esophagus | ESCC | 2.09e-08 | 1.41e-01 | 0.0894 |
7748 | ZNF195 | P40T-E | Human | Esophagus | ESCC | 1.52e-04 | 1.03e-01 | 0.109 |
7748 | ZNF195 | P42T-E | Human | Esophagus | ESCC | 5.79e-04 | 1.57e-01 | 0.1175 |
7748 | ZNF195 | P47T-E | Human | Esophagus | ESCC | 3.92e-13 | 9.16e-02 | 0.1067 |
7748 | ZNF195 | P48T-E | Human | Esophagus | ESCC | 3.70e-17 | 1.84e-01 | 0.0959 |
7748 | ZNF195 | P52T-E | Human | Esophagus | ESCC | 1.67e-16 | 3.12e-01 | 0.1555 |
7748 | ZNF195 | P54T-E | Human | Esophagus | ESCC | 9.53e-11 | 1.80e-01 | 0.0975 |
7748 | ZNF195 | P57T-E | Human | Esophagus | ESCC | 5.14e-04 | 1.13e-01 | 0.0926 |
7748 | ZNF195 | P61T-E | Human | Esophagus | ESCC | 4.45e-12 | 3.08e-01 | 0.099 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF195 | SNV | Missense_Mutation | c.1237G>A | p.Glu413Lys | p.E413K | O14628 | protein_coding | tolerated(0.1) | possibly_damaging(0.663) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF195 | deletion | Frame_Shift_Del | novel | c.1312delN | p.Tyr438ThrfsTer184 | p.Y438Tfs*184 | O14628 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZNF195 | SNV | Missense_Mutation | c.712A>C | p.Asn238His | p.N238H | O14628 | protein_coding | tolerated(1) | benign(0) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
ZNF195 | SNV | Missense_Mutation | novel | c.710G>T | p.Ser237Ile | p.S237I | O14628 | protein_coding | tolerated(0.54) | benign(0.022) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
ZNF195 | SNV | Missense_Mutation | c.698N>C | p.Arg233Thr | p.R233T | O14628 | protein_coding | tolerated(0.2) | probably_damaging(0.966) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF195 | SNV | Missense_Mutation | novel | c.1040A>G | p.His347Arg | p.H347R | O14628 | protein_coding | tolerated(1) | benign(0) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
ZNF195 | SNV | Missense_Mutation | rs775701149 | c.1204A>G | p.Arg402Gly | p.R402G | O14628 | protein_coding | tolerated(0.2) | benign(0.006) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF195 | SNV | Missense_Mutation | c.155N>C | p.Leu52Pro | p.L52P | O14628 | protein_coding | deleterious(0.05) | possibly_damaging(0.766) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF195 | SNV | Missense_Mutation | rs748909798 | c.598N>T | p.Asp200Tyr | p.D200Y | O14628 | protein_coding | tolerated(0.15) | probably_damaging(0.99) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF195 | SNV | Missense_Mutation | rs559329436 | c.1484N>T | p.Thr495Met | p.T495M | O14628 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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