Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZNF195

Gene summary for ZNF195

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZNF195

Gene ID

7748

Gene namezinc finger protein 195
Gene AliasHRF1
Cytomap11p15.4
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

O14628


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7748ZNF195P22T-EHumanEsophagusESCC1.44e-162.37e-010.1236
7748ZNF195P23T-EHumanEsophagusESCC2.29e-103.13e-010.108
7748ZNF195P24T-EHumanEsophagusESCC6.43e-091.51e-010.1287
7748ZNF195P26T-EHumanEsophagusESCC1.89e-222.81e-010.1276
7748ZNF195P27T-EHumanEsophagusESCC9.50e-122.96e-010.1055
7748ZNF195P28T-EHumanEsophagusESCC7.96e-192.58e-010.1149
7748ZNF195P30T-EHumanEsophagusESCC2.44e-051.47e-010.137
7748ZNF195P31T-EHumanEsophagusESCC2.04e-191.19e-010.1251
7748ZNF195P32T-EHumanEsophagusESCC5.64e-172.03e-010.1666
7748ZNF195P36T-EHumanEsophagusESCC2.74e-072.14e-010.1187
7748ZNF195P37T-EHumanEsophagusESCC2.25e-071.78e-010.1371
7748ZNF195P39T-EHumanEsophagusESCC2.09e-081.41e-010.0894
7748ZNF195P40T-EHumanEsophagusESCC1.52e-041.03e-010.109
7748ZNF195P42T-EHumanEsophagusESCC5.79e-041.57e-010.1175
7748ZNF195P47T-EHumanEsophagusESCC3.92e-139.16e-020.1067
7748ZNF195P48T-EHumanEsophagusESCC3.70e-171.84e-010.0959
7748ZNF195P52T-EHumanEsophagusESCC1.67e-163.12e-010.1555
7748ZNF195P54T-EHumanEsophagusESCC9.53e-111.80e-010.0975
7748ZNF195P57T-EHumanEsophagusESCC5.14e-041.13e-010.0926
7748ZNF195P61T-EHumanEsophagusESCC4.45e-123.08e-010.099
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ZNF195CD8TEXBreastDCISPOLA1,PITPNA-AS1,UACA, etc.1.33e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF195BNBreastHealthyPOLA1,PITPNA-AS1,UACA, etc.3.09e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF195MYOFIBColorectumADJNIPA2,TMEM116,IL6R, etc.3.31e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF195GLIAColorectumADJNIPA2,TMEM116,IL6R, etc.6.45e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF195MYOFIBColorectumCRCNIPA2,TMEM116,IL6R, etc.4.79e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF195ICAFColorectumFAPNIPA2,TMEM116,IL6R, etc.2.15e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF195PCVColorectumHealthyNIPA2,TMEM116,IL6R, etc.1.92e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF195MYOFIBColorectumMSI-HNIPA2,TMEM116,IL6R, etc.4.52e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF195MYOFIBColorectumSERNIPA2,TMEM116,IL6R, etc.2.55e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF195CD8TRMProstateHealthyGNLY,CTSW,PRF1, etc.3.35e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ZNF195SNVMissense_Mutationc.1237G>Ap.Glu413Lysp.E413KO14628protein_codingtolerated(0.1)possibly_damaging(0.663)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
ZNF195deletionFrame_Shift_Delnovelc.1312delNp.Tyr438ThrfsTer184p.Y438Tfs*184O14628protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
ZNF195SNVMissense_Mutationc.712A>Cp.Asn238Hisp.N238HO14628protein_codingtolerated(1)benign(0)TCGA-DS-A1OB-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinPD
ZNF195SNVMissense_Mutationnovelc.710G>Tp.Ser237Ilep.S237IO14628protein_codingtolerated(0.54)benign(0.022)TCGA-DS-A1OB-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinPD
ZNF195SNVMissense_Mutationc.698N>Cp.Arg233Thrp.R233TO14628protein_codingtolerated(0.2)probably_damaging(0.966)TCGA-IR-A3LK-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
ZNF195SNVMissense_Mutationnovelc.1040A>Gp.His347Argp.H347RO14628protein_codingtolerated(1)benign(0)TCGA-A6-6781-01Colorectumcolon adenocarcinomaMale<65III/IVChemotherapyoxaliplatinSD
ZNF195SNVMissense_Mutationrs775701149c.1204A>Gp.Arg402Glyp.R402GO14628protein_codingtolerated(0.2)benign(0.006)TCGA-AA-A00N-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
ZNF195SNVMissense_Mutationc.155N>Cp.Leu52Prop.L52PO14628protein_codingdeleterious(0.05)possibly_damaging(0.766)TCGA-AD-A5EJ-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
ZNF195SNVMissense_Mutationrs748909798c.598N>Tp.Asp200Tyrp.D200YO14628protein_codingtolerated(0.15)probably_damaging(0.99)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
ZNF195SNVMissense_Mutationrs559329436c.1484N>Tp.Thr495Metp.T495MO14628protein_codingdeleterious(0)probably_damaging(0.917)TCGA-AG-A02N-01Colorectumrectum adenocarcinomaMale>=65I/IIChemotherapyfolinicCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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