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Gene: ZNF143 |
Gene summary for ZNF143 |
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Gene information | Species | Human | Gene symbol | ZNF143 | Gene ID | 7702 |
Gene name | zinc finger protein 143 | |
Gene Alias | SBF | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P52747 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7702 | ZNF143 | P24T-E | Human | Esophagus | ESCC | 8.86e-05 | 1.28e-01 | 0.1287 |
7702 | ZNF143 | P26T-E | Human | Esophagus | ESCC | 6.61e-11 | 1.82e-01 | 0.1276 |
7702 | ZNF143 | P27T-E | Human | Esophagus | ESCC | 1.06e-10 | 1.41e-01 | 0.1055 |
7702 | ZNF143 | P28T-E | Human | Esophagus | ESCC | 1.97e-08 | 2.15e-01 | 0.1149 |
7702 | ZNF143 | P30T-E | Human | Esophagus | ESCC | 1.03e-10 | 3.77e-01 | 0.137 |
7702 | ZNF143 | P31T-E | Human | Esophagus | ESCC | 1.65e-13 | 1.92e-01 | 0.1251 |
7702 | ZNF143 | P32T-E | Human | Esophagus | ESCC | 2.31e-09 | 1.95e-01 | 0.1666 |
7702 | ZNF143 | P36T-E | Human | Esophagus | ESCC | 9.95e-09 | 2.55e-01 | 0.1187 |
7702 | ZNF143 | P37T-E | Human | Esophagus | ESCC | 1.09e-08 | 2.05e-01 | 0.1371 |
7702 | ZNF143 | P39T-E | Human | Esophagus | ESCC | 1.78e-09 | 1.43e-01 | 0.0894 |
7702 | ZNF143 | P42T-E | Human | Esophagus | ESCC | 9.56e-05 | 1.97e-01 | 0.1175 |
7702 | ZNF143 | P47T-E | Human | Esophagus | ESCC | 1.45e-06 | 8.52e-02 | 0.1067 |
7702 | ZNF143 | P48T-E | Human | Esophagus | ESCC | 3.52e-10 | 1.75e-01 | 0.0959 |
7702 | ZNF143 | P49T-E | Human | Esophagus | ESCC | 1.13e-09 | 7.07e-01 | 0.1768 |
7702 | ZNF143 | P52T-E | Human | Esophagus | ESCC | 1.08e-13 | 2.14e-01 | 0.1555 |
7702 | ZNF143 | P54T-E | Human | Esophagus | ESCC | 1.43e-03 | 1.60e-01 | 0.0975 |
7702 | ZNF143 | P57T-E | Human | Esophagus | ESCC | 4.56e-07 | 1.08e-01 | 0.0926 |
7702 | ZNF143 | P61T-E | Human | Esophagus | ESCC | 1.42e-04 | 1.07e-01 | 0.099 |
7702 | ZNF143 | P62T-E | Human | Esophagus | ESCC | 3.47e-24 | 3.93e-01 | 0.1302 |
7702 | ZNF143 | P65T-E | Human | Esophagus | ESCC | 4.76e-07 | 8.79e-02 | 0.0978 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063833 | Esophagus | ESCC | transcription by RNA polymerase III | 41/8552 | 46/18723 | 7.69e-10 | 1.90e-08 | 41 |
GO:00987812 | Esophagus | ESCC | ncRNA transcription | 45/8552 | 56/18723 | 1.05e-07 | 1.72e-06 | 45 |
GO:0006359 | Esophagus | ESCC | regulation of transcription by RNA polymerase III | 19/8552 | 22/18723 | 9.52e-05 | 6.78e-04 | 19 |
GO:00093011 | Esophagus | ESCC | snRNA transcription | 16/8552 | 19/18723 | 6.45e-04 | 3.43e-03 | 16 |
GO:0045945 | Esophagus | ESCC | positive regulation of transcription by RNA polymerase III | 10/8552 | 11/18723 | 2.54e-03 | 1.08e-02 | 10 |
GO:00427951 | Esophagus | ESCC | snRNA transcription by RNA polymerase II | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF143 | SNV | Missense_Mutation | novel | c.337N>T | p.Asp113Tyr | p.D113Y | P52747 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF143 | SNV | Missense_Mutation | rs766025125 | c.157N>A | p.Val53Ile | p.V53I | P52747 | protein_coding | deleterious(0.04) | benign(0.063) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ZNF143 | SNV | Missense_Mutation | c.702N>C | p.Glu234Asp | p.E234D | P52747 | protein_coding | tolerated(0.31) | benign(0.076) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
ZNF143 | insertion | Frame_Shift_Ins | novel | c.338_339insT | p.Gly114TrpfsTer13 | p.G114Wfs*13 | P52747 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF143 | SNV | Missense_Mutation | rs768865975 | c.142N>A | p.Val48Ile | p.V48I | P52747 | protein_coding | tolerated(0.1) | benign(0.017) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZNF143 | SNV | Missense_Mutation | rs775453952 | c.754N>T | p.His252Tyr | p.H252Y | P52747 | protein_coding | deleterious(0.03) | benign(0.027) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF143 | SNV | Missense_Mutation | c.305G>T | p.Arg102Leu | p.R102L | P52747 | protein_coding | tolerated(0.17) | benign(0.097) | TCGA-FU-A57G-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF143 | SNV | Missense_Mutation | rs762077968 | c.68N>T | p.Ala23Val | p.A23V | P52747 | protein_coding | deleterious_low_confidence(0.01) | benign(0.027) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF143 | SNV | Missense_Mutation | c.1324N>A | p.Asp442Asn | p.D442N | P52747 | protein_coding | deleterious(0.02) | probably_damaging(0.972) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF143 | SNV | Missense_Mutation | c.1234N>G | p.Thr412Ala | p.T412A | P52747 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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