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Gene: ZIC1 |
Gene summary for ZIC1 |
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Gene information | Species | Human | Gene symbol | ZIC1 | Gene ID | 7545 |
Gene name | Zic family member 1 | |
Gene Alias | BAIDCS | |
Cytomap | 3q24 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q15915 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7545 | ZIC1 | P61T-E | Human | Esophagus | ESCC | 1.60e-19 | 4.66e-01 | 0.099 |
7545 | ZIC1 | P74T-E | Human | Esophagus | ESCC | 1.97e-54 | 1.33e+00 | 0.1479 |
7545 | ZIC1 | P82T-E | Human | Esophagus | ESCC | 4.25e-08 | 6.21e-01 | 0.1072 |
7545 | ZIC1 | P83T-E | Human | Esophagus | ESCC | 3.38e-25 | 5.81e-01 | 0.1738 |
7545 | ZIC1 | P89T-E | Human | Esophagus | ESCC | 4.62e-24 | 1.31e+00 | 0.1752 |
7545 | ZIC1 | P91T-E | Human | Esophagus | ESCC | 4.77e-11 | 6.84e-01 | 0.1828 |
7545 | ZIC1 | P107T-E | Human | Esophagus | ESCC | 4.76e-30 | 5.81e-01 | 0.171 |
7545 | ZIC1 | P126T-E | Human | Esophagus | ESCC | 7.86e-04 | 3.37e-01 | 0.1125 |
7545 | ZIC1 | P127T-E | Human | Esophagus | ESCC | 2.37e-34 | 5.59e-01 | 0.0826 |
7545 | ZIC1 | HCC1_Meng | Human | Liver | HCC | 1.14e-12 | 2.91e-02 | 0.0246 |
7545 | ZIC1 | S014 | Human | Liver | HCC | 1.26e-28 | 1.15e+00 | 0.2254 |
7545 | ZIC1 | S015 | Human | Liver | HCC | 8.10e-28 | 1.02e+00 | 0.2375 |
7545 | ZIC1 | S016 | Human | Liver | HCC | 8.76e-36 | 1.15e+00 | 0.2243 |
7545 | ZIC1 | S028 | Human | Liver | HCC | 1.54e-07 | 3.44e-01 | 0.2503 |
7545 | ZIC1 | S029 | Human | Liver | HCC | 3.24e-05 | 2.72e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
GO:0033157110 | Esophagus | ESCC | regulation of intracellular protein transport | 169/8552 | 229/18723 | 3.31e-18 | 3.23e-16 | 169 |
GO:0032388110 | Esophagus | ESCC | positive regulation of intracellular transport | 152/8552 | 202/18723 | 7.89e-18 | 7.36e-16 | 152 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0046822110 | Esophagus | ESCC | regulation of nucleocytoplasmic transport | 88/8552 | 106/18723 | 1.88e-15 | 1.19e-13 | 88 |
GO:009031617 | Esophagus | ESCC | positive regulation of intracellular protein transport | 122/8552 | 160/18723 | 2.45e-15 | 1.49e-13 | 122 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:190018018 | Esophagus | ESCC | regulation of protein localization to nucleus | 102/8552 | 136/18723 | 2.84e-12 | 1.13e-10 | 102 |
GO:190018217 | Esophagus | ESCC | positive regulation of protein localization to nucleus | 70/8552 | 87/18723 | 2.63e-11 | 8.99e-10 | 70 |
GO:004682417 | Esophagus | ESCC | positive regulation of nucleocytoplasmic transport | 52/8552 | 62/18723 | 5.40e-10 | 1.38e-08 | 52 |
GO:005117014 | Esophagus | ESCC | import into nucleus | 111/8552 | 159/18723 | 5.69e-10 | 1.44e-08 | 111 |
GO:000660613 | Esophagus | ESCC | protein import into nucleus | 108/8552 | 155/18723 | 1.16e-09 | 2.77e-08 | 108 |
GO:190458914 | Esophagus | ESCC | regulation of protein import | 49/8552 | 63/18723 | 1.91e-07 | 2.97e-06 | 49 |
GO:190459116 | Esophagus | ESCC | positive regulation of protein import | 36/8552 | 43/18723 | 2.90e-07 | 4.20e-06 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZIC1 | SNV | Missense_Mutation | c.557C>T | p.Ser186Leu | p.S186L | Q15915 | protein_coding | deleterious(0.03) | benign(0.069) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
ZIC1 | SNV | Missense_Mutation | novel | c.963N>G | p.Ile321Met | p.I321M | Q15915 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ZIC1 | SNV | Missense_Mutation | novel | c.1003G>A | p.Glu335Lys | p.E335K | Q15915 | protein_coding | deleterious(0.02) | benign(0.061) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZIC1 | SNV | Missense_Mutation | novel | c.1139A>G | p.His380Arg | p.H380R | Q15915 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZIC1 | SNV | Missense_Mutation | c.1042N>A | p.Asp348Asn | p.D348N | Q15915 | protein_coding | deleterious(0) | possibly_damaging(0.742) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZIC1 | SNV | Missense_Mutation | c.385G>A | p.Gly129Arg | p.G129R | Q15915 | protein_coding | tolerated(0.37) | benign(0.003) | TCGA-DR-A0ZL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZIC1 | SNV | Missense_Mutation | novel | c.940G>A | p.Ala314Thr | p.A314T | Q15915 | protein_coding | deleterious(0) | possibly_damaging(0.578) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ZIC1 | SNV | Missense_Mutation | c.1196N>T | p.Ser399Phe | p.S399F | Q15915 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-FU-A3HY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZIC1 | SNV | Missense_Mutation | c.706N>A | p.Ala236Thr | p.A236T | Q15915 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZIC1 | SNV | Missense_Mutation | c.971G>T | p.Arg324Met | p.R324M | Q15915 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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