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Gene: ZDBF2 |
Gene summary for ZDBF2 |
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Gene information | Species | Human | Gene symbol | ZDBF2 | Gene ID | 57683 |
Gene name | zinc finger DBF-type containing 2 | |
Gene Alias | Slx9 | |
Cytomap | 2q33.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | N0DVX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57683 | ZDBF2 | PTC05 | Human | Thyroid | PTC | 5.18e-13 | 3.17e-01 | 0.2065 |
57683 | ZDBF2 | PTC06 | Human | Thyroid | PTC | 9.94e-09 | 2.55e-01 | 0.2057 |
57683 | ZDBF2 | PTC07 | Human | Thyroid | PTC | 2.25e-13 | 2.51e-01 | 0.2044 |
57683 | ZDBF2 | ATC12 | Human | Thyroid | ATC | 2.13e-05 | 7.18e-02 | 0.34 |
57683 | ZDBF2 | ATC13 | Human | Thyroid | ATC | 5.29e-68 | 1.14e+00 | 0.34 |
57683 | ZDBF2 | ATC4 | Human | Thyroid | ATC | 9.10e-05 | 8.09e-02 | 0.34 |
57683 | ZDBF2 | ATC5 | Human | Thyroid | ATC | 4.83e-63 | 1.23e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZDBF2 | SNV | Missense_Mutation | c.6529N>G | p.His2177Asp | p.H2177D | Q9HCK1 | protein_coding | tolerated(0.28) | benign(0.023) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
ZDBF2 | SNV | Missense_Mutation | c.2125N>T | p.Asp709Tyr | p.D709Y | Q9HCK1 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-A8-A07I-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
ZDBF2 | SNV | Missense_Mutation | novel | c.3068N>T | p.Arg1023Ile | p.R1023I | Q9HCK1 | protein_coding | tolerated(0.17) | possibly_damaging(0.797) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | novel | c.4442N>G | p.Glu1481Gly | p.E1481G | Q9HCK1 | protein_coding | tolerated(0.08) | possibly_damaging(0.452) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | rs749703720 | c.5024N>A | p.Arg1675Gln | p.R1675Q | Q9HCK1 | protein_coding | tolerated(0.07) | benign(0.052) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | novel | c.7046N>T | p.Arg2349Ile | p.R2349I | Q9HCK1 | protein_coding | deleterious(0) | benign(0.091) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | novel | c.6959N>G | p.Ser2320Cys | p.S2320C | Q9HCK1 | protein_coding | tolerated(0.18) | benign(0) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | c.3345N>T | p.Lys1115Asn | p.K1115N | Q9HCK1 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZDBF2 | SNV | Missense_Mutation | novel | c.3208N>A | p.Asp1070Asn | p.D1070N | Q9HCK1 | protein_coding | tolerated(0.21) | benign(0.034) | TCGA-B6-A400-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | rs781279011 | c.6683C>T | p.Ser2228Leu | p.S2228L | Q9HCK1 | protein_coding | tolerated(0.66) | benign(0.023) | TCGA-BH-A0DG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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