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Gene: ZBTB7B |
Gene summary for ZBTB7B |
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Gene information | Species | Human | Gene symbol | ZBTB7B | Gene ID | 51043 |
Gene name | zinc finger and BTB domain containing 7B | |
Gene Alias | CKROX | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O15156 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51043 | ZBTB7B | P17T-E | Human | Esophagus | ESCC | 1.23e-04 | 8.51e-02 | 0.1278 |
51043 | ZBTB7B | P20T-E | Human | Esophagus | ESCC | 1.74e-12 | 2.95e-01 | 0.1124 |
51043 | ZBTB7B | P21T-E | Human | Esophagus | ESCC | 1.68e-09 | 8.80e-02 | 0.1617 |
51043 | ZBTB7B | P22T-E | Human | Esophagus | ESCC | 1.38e-09 | -6.25e-03 | 0.1236 |
51043 | ZBTB7B | P23T-E | Human | Esophagus | ESCC | 5.02e-11 | 3.40e-01 | 0.108 |
51043 | ZBTB7B | P24T-E | Human | Esophagus | ESCC | 1.10e-15 | 1.51e-01 | 0.1287 |
51043 | ZBTB7B | P26T-E | Human | Esophagus | ESCC | 1.03e-04 | 3.39e-02 | 0.1276 |
51043 | ZBTB7B | P27T-E | Human | Esophagus | ESCC | 9.50e-11 | 5.88e-02 | 0.1055 |
51043 | ZBTB7B | P28T-E | Human | Esophagus | ESCC | 9.83e-15 | 3.28e-01 | 0.1149 |
51043 | ZBTB7B | P30T-E | Human | Esophagus | ESCC | 1.25e-20 | 7.32e-01 | 0.137 |
51043 | ZBTB7B | P31T-E | Human | Esophagus | ESCC | 6.87e-13 | 6.03e-02 | 0.1251 |
51043 | ZBTB7B | P32T-E | Human | Esophagus | ESCC | 5.02e-06 | -3.01e-02 | 0.1666 |
51043 | ZBTB7B | P36T-E | Human | Esophagus | ESCC | 2.66e-13 | 3.35e-01 | 0.1187 |
51043 | ZBTB7B | P37T-E | Human | Esophagus | ESCC | 4.23e-07 | 1.16e-01 | 0.1371 |
51043 | ZBTB7B | P39T-E | Human | Esophagus | ESCC | 4.33e-15 | 8.82e-02 | 0.0894 |
51043 | ZBTB7B | P42T-E | Human | Esophagus | ESCC | 3.41e-16 | 3.15e-01 | 0.1175 |
51043 | ZBTB7B | P44T-E | Human | Esophagus | ESCC | 3.56e-02 | -6.94e-04 | 0.1096 |
51043 | ZBTB7B | P47T-E | Human | Esophagus | ESCC | 2.45e-15 | 1.72e-01 | 0.1067 |
51043 | ZBTB7B | P48T-E | Human | Esophagus | ESCC | 1.37e-21 | 1.40e-01 | 0.0959 |
51043 | ZBTB7B | P49T-E | Human | Esophagus | ESCC | 7.23e-03 | 8.19e-01 | 0.1768 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0006984 | Colorectum | AD | ER-nucleus signaling pathway | 21/3918 | 46/18723 | 1.47e-04 | 2.08e-03 | 21 |
GO:0050878 | Colorectum | AD | regulation of body fluid levels | 108/3918 | 379/18723 | 2.54e-04 | 3.20e-03 | 108 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:0007589 | Colorectum | AD | body fluid secretion | 33/3918 | 93/18723 | 8.26e-04 | 8.13e-03 | 33 |
GO:0032933 | Colorectum | AD | SREBP signaling pathway | 9/3918 | 15/18723 | 1.11e-03 | 1.01e-02 | 9 |
GO:0071501 | Colorectum | AD | cellular response to sterol depletion | 9/3918 | 16/18723 | 2.06e-03 | 1.64e-02 | 9 |
GO:1903706 | Colorectum | AD | regulation of hemopoiesis | 99/3918 | 367/18723 | 3.08e-03 | 2.28e-02 | 99 |
GO:0120162 | Colorectum | AD | positive regulation of cold-induced thermogenesis | 32/3918 | 97/18723 | 3.74e-03 | 2.63e-02 | 32 |
GO:0007595 | Colorectum | AD | lactation | 18/3918 | 47/18723 | 4.81e-03 | 3.25e-02 | 18 |
GO:0006991 | Colorectum | AD | response to sterol depletion | 9/3918 | 18/18723 | 5.82e-03 | 3.67e-02 | 9 |
GO:0031056 | Colorectum | AD | regulation of histone modification | 45/3918 | 152/18723 | 7.05e-03 | 4.31e-02 | 45 |
GO:0106106 | Colorectum | AD | cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
GO:0120161 | Colorectum | AD | regulation of cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB7B | SNV | Missense_Mutation | novel | c.1385N>A | p.Arg462Gln | p.R462Q | O15156 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C8-A26Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
ZBTB7B | SNV | Missense_Mutation | c.110N>A | p.Ser37Asn | p.S37N | O15156 | protein_coding | tolerated(0.53) | probably_damaging(0.969) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB7B | SNV | Missense_Mutation | c.1024N>C | p.Asp342His | p.D342H | O15156 | protein_coding | deleterious(0.04) | probably_damaging(0.988) | TCGA-D8-A27I-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adrimycin+cyclophosphamide | SD | |
ZBTB7B | SNV | Missense_Mutation | c.895N>A | p.Glu299Lys | p.E299K | O15156 | protein_coding | tolerated(0.25) | benign(0.222) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZBTB7B | SNV | Missense_Mutation | c.232G>A | p.Glu78Lys | p.E78K | O15156 | protein_coding | deleterious(0.01) | benign(0.161) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZBTB7B | insertion | In_Frame_Ins | novel | c.690_691insCCCAAA | p.Pro230_Val231insProLys | p.P230_V231insPK | O15156 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
ZBTB7B | SNV | Missense_Mutation | c.1120N>T | p.Arg374Cys | p.R374C | O15156 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB7B | SNV | Missense_Mutation | c.274T>C | p.Tyr92His | p.Y92H | O15156 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | PD | |
ZBTB7B | SNV | Missense_Mutation | c.968N>T | p.Gly323Val | p.G323V | O15156 | protein_coding | tolerated(0.07) | probably_damaging(0.977) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
ZBTB7B | SNV | Missense_Mutation | c.651G>T | p.Gln217His | p.Q217H | O15156 | protein_coding | tolerated(0.39) | probably_damaging(0.923) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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