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Gene: YPEL5 |
Gene summary for YPEL5 |
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Gene information | Species | Human | Gene symbol | YPEL5 | Gene ID | 51646 |
Gene name | yippee like 5 | |
Gene Alias | CGI-127 | |
Cytomap | 2p23.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P62699 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51646 | YPEL5 | P24T-E | Human | Esophagus | ESCC | 5.07e-22 | 6.96e-01 | 0.1287 |
51646 | YPEL5 | P26T-E | Human | Esophagus | ESCC | 3.25e-68 | 1.76e+00 | 0.1276 |
51646 | YPEL5 | P27T-E | Human | Esophagus | ESCC | 2.34e-33 | 1.16e+00 | 0.1055 |
51646 | YPEL5 | P28T-E | Human | Esophagus | ESCC | 1.28e-33 | 1.02e+00 | 0.1149 |
51646 | YPEL5 | P30T-E | Human | Esophagus | ESCC | 3.88e-29 | 1.76e+00 | 0.137 |
51646 | YPEL5 | P31T-E | Human | Esophagus | ESCC | 1.15e-20 | 4.44e-01 | 0.1251 |
51646 | YPEL5 | P32T-E | Human | Esophagus | ESCC | 1.12e-16 | 4.82e-01 | 0.1666 |
51646 | YPEL5 | P36T-E | Human | Esophagus | ESCC | 3.67e-15 | 9.92e-01 | 0.1187 |
51646 | YPEL5 | P37T-E | Human | Esophagus | ESCC | 6.66e-10 | 4.05e-01 | 0.1371 |
51646 | YPEL5 | P38T-E | Human | Esophagus | ESCC | 7.15e-04 | 5.42e-01 | 0.127 |
51646 | YPEL5 | P39T-E | Human | Esophagus | ESCC | 3.41e-23 | 7.81e-01 | 0.0894 |
51646 | YPEL5 | P40T-E | Human | Esophagus | ESCC | 1.63e-09 | 7.60e-01 | 0.109 |
51646 | YPEL5 | P42T-E | Human | Esophagus | ESCC | 1.72e-13 | 8.14e-01 | 0.1175 |
51646 | YPEL5 | P44T-E | Human | Esophagus | ESCC | 3.46e-11 | 4.46e-01 | 0.1096 |
51646 | YPEL5 | P47T-E | Human | Esophagus | ESCC | 1.56e-32 | 1.03e+00 | 0.1067 |
51646 | YPEL5 | P48T-E | Human | Esophagus | ESCC | 5.98e-21 | 8.95e-01 | 0.0959 |
51646 | YPEL5 | P49T-E | Human | Esophagus | ESCC | 2.10e-19 | 2.08e+00 | 0.1768 |
51646 | YPEL5 | P52T-E | Human | Esophagus | ESCC | 1.89e-08 | 6.11e-01 | 0.1555 |
51646 | YPEL5 | P54T-E | Human | Esophagus | ESCC | 4.57e-25 | 1.31e+00 | 0.0975 |
51646 | YPEL5 | P56T-E | Human | Esophagus | ESCC | 5.34e-07 | 1.49e+00 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YPEL5 | SNV | Missense_Mutation | c.5N>A | p.Gly2Asp | p.G2D | P62699 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
YPEL5 | SNV | Missense_Mutation | c.355N>C | p.Asp119His | p.D119H | P62699 | protein_coding | deleterious_low_confidence(0) | benign(0.308) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
YPEL5 | SNV | Missense_Mutation | rs370740580 | c.25A>G | p.Ile9Val | p.I9V | P62699 | protein_coding | tolerated(0.41) | benign(0.003) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
YPEL5 | SNV | Missense_Mutation | c.122N>A | p.Arg41Lys | p.R41K | P62699 | protein_coding | tolerated(0.11) | possibly_damaging(0.622) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
YPEL5 | SNV | Missense_Mutation | c.307C>T | p.Arg103Cys | p.R103C | P62699 | protein_coding | deleterious(0) | benign(0.063) | TCGA-B5-A0JR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
YPEL5 | SNV | Missense_Mutation | c.163G>A | p.Glu55Lys | p.E55K | P62699 | protein_coding | tolerated(0.12) | benign(0.043) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
YPEL5 | SNV | Missense_Mutation | novel | c.175C>T | p.Arg59Trp | p.R59W | P62699 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
YPEL5 | SNV | Missense_Mutation | novel | c.320N>A | p.Arg107Gln | p.R107Q | P62699 | protein_coding | tolerated(0.65) | benign(0.007) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
YPEL5 | SNV | Missense_Mutation | novel | c.45T>G | p.Phe15Leu | p.F15L | P62699 | protein_coding | tolerated(0.05) | benign(0.038) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
YPEL5 | SNV | Missense_Mutation | novel | c.302T>C | p.Leu101Pro | p.L101P | P62699 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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