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Gene: YAE1D1 |
Gene summary for YAE1D1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | YAE1D1 | Gene ID | 57002 |
| Gene name | YAE1 maturation factor of ABCE1 | |
| Gene Alias | C7orf36 | |
| Cytomap | 7p14.1 | |
| Gene Type | protein-coding | GO ID | GO:0006807 | UniProtAcc | Q9NRH1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57002 | YAE1D1 | P28T-E | Human | Esophagus | ESCC | 4.65e-23 | 3.62e-01 | 0.1149 |
| 57002 | YAE1D1 | P30T-E | Human | Esophagus | ESCC | 7.61e-20 | 4.19e-01 | 0.137 |
| 57002 | YAE1D1 | P31T-E | Human | Esophagus | ESCC | 4.06e-15 | 2.78e-01 | 0.1251 |
| 57002 | YAE1D1 | P32T-E | Human | Esophagus | ESCC | 7.87e-21 | 4.68e-01 | 0.1666 |
| 57002 | YAE1D1 | P36T-E | Human | Esophagus | ESCC | 6.88e-08 | 2.32e-01 | 0.1187 |
| 57002 | YAE1D1 | P37T-E | Human | Esophagus | ESCC | 1.61e-12 | 3.06e-01 | 0.1371 |
| 57002 | YAE1D1 | P38T-E | Human | Esophagus | ESCC | 1.17e-03 | 1.49e-01 | 0.127 |
| 57002 | YAE1D1 | P39T-E | Human | Esophagus | ESCC | 1.22e-13 | 2.33e-01 | 0.0894 |
| 57002 | YAE1D1 | P40T-E | Human | Esophagus | ESCC | 2.26e-07 | 2.00e-01 | 0.109 |
| 57002 | YAE1D1 | P42T-E | Human | Esophagus | ESCC | 1.25e-15 | 3.73e-01 | 0.1175 |
| 57002 | YAE1D1 | P44T-E | Human | Esophagus | ESCC | 9.03e-05 | 2.15e-01 | 0.1096 |
| 57002 | YAE1D1 | P47T-E | Human | Esophagus | ESCC | 2.73e-11 | 1.99e-01 | 0.1067 |
| 57002 | YAE1D1 | P48T-E | Human | Esophagus | ESCC | 7.09e-15 | 1.50e-01 | 0.0959 |
| 57002 | YAE1D1 | P49T-E | Human | Esophagus | ESCC | 6.51e-06 | 4.77e-01 | 0.1768 |
| 57002 | YAE1D1 | P52T-E | Human | Esophagus | ESCC | 2.80e-26 | 4.90e-01 | 0.1555 |
| 57002 | YAE1D1 | P54T-E | Human | Esophagus | ESCC | 3.22e-15 | 2.88e-01 | 0.0975 |
| 57002 | YAE1D1 | P56T-E | Human | Esophagus | ESCC | 9.50e-06 | 9.04e-01 | 0.1613 |
| 57002 | YAE1D1 | P57T-E | Human | Esophagus | ESCC | 1.56e-13 | 1.55e-01 | 0.0926 |
| 57002 | YAE1D1 | P61T-E | Human | Esophagus | ESCC | 8.81e-23 | 2.34e-01 | 0.099 |
| 57002 | YAE1D1 | P62T-E | Human | Esophagus | ESCC | 1.27e-23 | 4.07e-01 | 0.1302 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| YAE1D1 | SNV | Missense_Mutation | c.445G>C | p.Glu149Gln | p.E149Q | Q9NRH1 | protein_coding | tolerated(0.29) | benign(0.006) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| YAE1D1 | SNV | Missense_Mutation | c.534N>G | p.Ile178Met | p.I178M | Q9NRH1 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| YAE1D1 | SNV | Missense_Mutation | rs767689486 | c.227N>G | p.Tyr76Cys | p.Y76C | Q9NRH1 | protein_coding | tolerated(0.12) | probably_damaging(1) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
| YAE1D1 | SNV | Missense_Mutation | rs767147083 | c.524N>G | p.His175Arg | p.H175R | Q9NRH1 | protein_coding | tolerated(0.54) | benign(0.001) | TCGA-FI-A2F9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| YAE1D1 | SNV | Missense_Mutation | c.233N>T | p.Arg78Leu | p.R78L | Q9NRH1 | protein_coding | tolerated(0.1) | benign(0.001) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| YAE1D1 | SNV | Missense_Mutation | rs773458006 | c.76N>A | p.Glu26Lys | p.E26K | Q9NRH1 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| YAE1D1 | SNV | Missense_Mutation | novel | c.146N>C | p.Gly49Ala | p.G49A | Q9NRH1 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-73-4658-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| YAE1D1 | SNV | Missense_Mutation | c.130N>A | p.Glu44Lys | p.E44K | Q9NRH1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-78-7149-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
| YAE1D1 | SNV | Missense_Mutation | rs749934423 | c.416N>T | p.Asp139Val | p.D139V | Q9NRH1 | protein_coding | deleterious(0) | benign(0.422) | TCGA-22-4593-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| YAE1D1 | SNV | Missense_Mutation | novel | c.526N>T | p.Ser176Cys | p.S176C | Q9NRH1 | protein_coding | deleterious(0.03) | benign(0.43) | TCGA-39-5034-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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