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Gene: XACT |
Gene summary for XACT |
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Gene information | Species | Human | Gene symbol | XACT | Gene ID | 105463123 |
Gene name | X active specific transcript | |
Gene Alias | XACT | |
Cytomap | Xq23 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
105463123 | XACT | A002-C-203 | Human | Colorectum | FAP | 1.20e-51 | 6.66e-01 | 0.2786 |
105463123 | XACT | A001-C-119 | Human | Colorectum | FAP | 5.80e-16 | -9.13e-01 | -0.1557 |
105463123 | XACT | A002-C-021 | Human | Colorectum | FAP | 1.94e-15 | 4.50e-01 | 0.1171 |
105463123 | XACT | A002-C-205 | Human | Colorectum | FAP | 2.27e-08 | 2.51e-01 | -0.1236 |
105463123 | XACT | A015-C-006 | Human | Colorectum | FAP | 1.65e-05 | -4.47e-01 | -0.0994 |
105463123 | XACT | A015-C-106 | Human | Colorectum | FAP | 1.12e-03 | 2.28e-01 | -0.0511 |
105463123 | XACT | A002-C-114 | Human | Colorectum | FAP | 4.23e-12 | 3.30e-01 | -0.1561 |
105463123 | XACT | A015-C-104 | Human | Colorectum | FAP | 2.15e-05 | -2.37e-01 | -0.1899 |
105463123 | XACT | A015-C-202 | Human | Colorectum | FAP | 2.30e-02 | -1.12e-01 | -0.0849 |
105463123 | XACT | A002-C-016 | Human | Colorectum | FAP | 2.29e-07 | 3.08e-01 | 0.0521 |
105463123 | XACT | A015-C-002 | Human | Colorectum | FAP | 2.45e-05 | 3.20e-01 | -0.0763 |
105463123 | XACT | A001-C-007 | Human | Colorectum | CRC | 3.06e-05 | -6.05e-01 | 0.1899 |
105463123 | XACT | A002-C-116 | Human | Colorectum | FAP | 2.56e-12 | 3.27e-01 | -0.0452 |
105463123 | XACT | A008-E-015 | Human | Colorectum | FAP | 3.00e-02 | 1.40e-01 | 0.0177 |
105463123 | XACT | A014-C-008 | Human | Colorectum | FAP | 3.53e-14 | 3.59e-01 | -0.191 |
105463123 | XACT | F034 | Human | Colorectum | FAP | 1.23e-05 | 2.87e-01 | -0.0665 |
105463123 | XACT | F072B | Human | Colorectum | FAP | 7.85e-08 | -4.78e-01 | 0.257 |
105463123 | XACT | CRC-1-8810 | Human | Colorectum | CRC | 1.68e-79 | -1.54e+00 | 0.6257 |
105463123 | XACT | CRC-3-11773 | Human | Colorectum | CRC | 7.27e-59 | -1.33e+00 | 0.2564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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