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Gene: WSB2 |
Gene summary for WSB2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | WSB2 | Gene ID | 55884 |
| Gene name | WD repeat and SOCS box containing 2 | |
| Gene Alias | SBA2 | |
| Cytomap | 12q24.23 | |
| Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9NYS7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55884 | WSB2 | C09 | Human | Oral cavity | OSCC | 2.55e-03 | 2.95e-01 | 0.1431 |
| 55884 | WSB2 | LN22 | Human | Oral cavity | OSCC | 5.51e-04 | 6.54e-01 | 0.1733 |
| 55884 | WSB2 | LN46 | Human | Oral cavity | OSCC | 2.55e-02 | 2.68e-01 | 0.1666 |
| 55884 | WSB2 | LP17 | Human | Oral cavity | LP | 2.33e-02 | 7.65e-01 | 0.2349 |
| 55884 | WSB2 | SYSMH1 | Human | Oral cavity | OSCC | 4.43e-21 | 4.35e-01 | 0.1127 |
| 55884 | WSB2 | SYSMH2 | Human | Oral cavity | OSCC | 1.06e-12 | 3.69e-01 | 0.2326 |
| 55884 | WSB2 | SYSMH3 | Human | Oral cavity | OSCC | 2.90e-12 | 3.30e-01 | 0.2442 |
| 55884 | WSB2 | SYSMH6 | Human | Oral cavity | OSCC | 2.45e-02 | 1.57e-01 | 0.1275 |
| 55884 | WSB2 | P4_S8_cSCC | Human | Skin | cSCC | 4.28e-02 | 1.27e-01 | -0.3095 |
| 55884 | WSB2 | P1_cSCC | Human | Skin | cSCC | 3.07e-18 | 5.55e-01 | 0.0292 |
| 55884 | WSB2 | P2_cSCC | Human | Skin | cSCC | 9.87e-05 | 2.25e-01 | -0.024 |
| 55884 | WSB2 | P4_cSCC | Human | Skin | cSCC | 5.83e-11 | 2.80e-01 | -0.00290000000000005 |
| 55884 | WSB2 | P10_cSCC | Human | Skin | cSCC | 4.59e-18 | 5.18e-01 | 0.1017 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| WSB2 | SNV | Missense_Mutation | c.1250N>A | p.Thr417Lys | p.T417K | Q9NYS7 | protein_coding | deleterious(0.03) | possibly_damaging(0.495) | TCGA-AR-A0U3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| WSB2 | insertion | Frame_Shift_Ins | novel | c.758_759insATGCATCTTGAGCCCTT | p.Gly254CysfsTer33 | p.G254Cfs*33 | Q9NYS7 | protein_coding | TCGA-A8-A09B-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
| WSB2 | SNV | Missense_Mutation | rs781441613 | c.904N>A | p.Ala302Thr | p.A302T | Q9NYS7 | protein_coding | tolerated(0.61) | benign(0.001) | TCGA-UC-A7PD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
| WSB2 | SNV | Missense_Mutation | rs550650687 | c.289N>T | p.Arg97Trp | p.R97W | Q9NYS7 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| WSB2 | SNV | Missense_Mutation | c.410A>G | p.Asp137Gly | p.D137G | Q9NYS7 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| WSB2 | SNV | Missense_Mutation | novel | c.392N>G | p.His131Arg | p.H131R | Q9NYS7 | protein_coding | tolerated(0.34) | benign(0) | TCGA-AA-3846-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| WSB2 | SNV | Missense_Mutation | novel | c.619N>G | p.Ile207Val | p.I207V | Q9NYS7 | protein_coding | tolerated(1) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| WSB2 | SNV | Missense_Mutation | c.104C>A | p.Pro35His | p.P35H | Q9NYS7 | protein_coding | deleterious(0.01) | benign(0.243) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| WSB2 | SNV | Missense_Mutation | c.806N>T | p.Ala269Val | p.A269V | Q9NYS7 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| WSB2 | SNV | Missense_Mutation | c.511G>A | p.Asp171Asn | p.D171N | Q9NYS7 | protein_coding | deleterious(0.02) | possibly_damaging(0.807) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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