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Gene: WRNIP1 |
Gene summary for WRNIP1 |
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Gene information | Species | Human | Gene symbol | WRNIP1 | Gene ID | 56897 |
Gene name | WRN helicase interacting protein 1 | |
Gene Alias | CFAP93 | |
Cytomap | 6p25.2 | |
Gene Type | protein-coding | GO ID | GO:0000731 | UniProtAcc | Q96S55 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56897 | WRNIP1 | P28T-E | Human | Esophagus | ESCC | 1.57e-19 | 3.09e-01 | 0.1149 |
56897 | WRNIP1 | P30T-E | Human | Esophagus | ESCC | 3.63e-30 | 6.45e-01 | 0.137 |
56897 | WRNIP1 | P31T-E | Human | Esophagus | ESCC | 6.34e-16 | 1.56e-01 | 0.1251 |
56897 | WRNIP1 | P32T-E | Human | Esophagus | ESCC | 4.84e-11 | 2.69e-02 | 0.1666 |
56897 | WRNIP1 | P36T-E | Human | Esophagus | ESCC | 1.18e-03 | 1.24e-02 | 0.1187 |
56897 | WRNIP1 | P37T-E | Human | Esophagus | ESCC | 5.00e-15 | 1.74e-01 | 0.1371 |
56897 | WRNIP1 | P38T-E | Human | Esophagus | ESCC | 1.23e-08 | 2.12e-01 | 0.127 |
56897 | WRNIP1 | P39T-E | Human | Esophagus | ESCC | 1.14e-15 | 9.38e-02 | 0.0894 |
56897 | WRNIP1 | P40T-E | Human | Esophagus | ESCC | 1.95e-13 | 1.98e-01 | 0.109 |
56897 | WRNIP1 | P42T-E | Human | Esophagus | ESCC | 1.63e-10 | 1.43e-01 | 0.1175 |
56897 | WRNIP1 | P44T-E | Human | Esophagus | ESCC | 1.46e-08 | 1.42e-01 | 0.1096 |
56897 | WRNIP1 | P47T-E | Human | Esophagus | ESCC | 2.88e-22 | 2.09e-01 | 0.1067 |
56897 | WRNIP1 | P48T-E | Human | Esophagus | ESCC | 1.53e-13 | 1.10e-01 | 0.0959 |
56897 | WRNIP1 | P52T-E | Human | Esophagus | ESCC | 3.54e-13 | 1.82e-01 | 0.1555 |
56897 | WRNIP1 | P54T-E | Human | Esophagus | ESCC | 2.60e-16 | 2.42e-01 | 0.0975 |
56897 | WRNIP1 | P56T-E | Human | Esophagus | ESCC | 1.86e-08 | 5.91e-01 | 0.1613 |
56897 | WRNIP1 | P57T-E | Human | Esophagus | ESCC | 2.57e-10 | 5.40e-02 | 0.0926 |
56897 | WRNIP1 | P61T-E | Human | Esophagus | ESCC | 6.62e-08 | 1.50e-01 | 0.099 |
56897 | WRNIP1 | P62T-E | Human | Esophagus | ESCC | 1.39e-15 | 2.01e-01 | 0.1302 |
56897 | WRNIP1 | P65T-E | Human | Esophagus | ESCC | 1.64e-16 | 1.93e-01 | 0.0978 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:007189716 | Esophagus | ESCC | DNA biosynthetic process | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:00062754 | Esophagus | ESCC | regulation of DNA replication | 73/8552 | 107/18723 | 1.97e-06 | 2.28e-05 | 73 |
GO:003239214 | Esophagus | ESCC | DNA geometric change | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:003250813 | Esophagus | ESCC | DNA duplex unwinding | 58/8552 | 84/18723 | 1.23e-05 | 1.14e-04 | 58 |
GO:00062826 | Esophagus | ESCC | regulation of DNA repair | 82/8552 | 130/18723 | 4.65e-05 | 3.66e-04 | 82 |
GO:00062701 | Esophagus | ESCC | DNA replication initiation | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
GO:0090329 | Esophagus | ESCC | regulation of DNA-dependent DNA replication | 30/8552 | 46/18723 | 5.91e-03 | 2.18e-02 | 30 |
GO:005105221 | Liver | HCC | regulation of DNA metabolic process | 198/7958 | 359/18723 | 7.62e-07 | 1.17e-05 | 198 |
GO:200102021 | Liver | HCC | regulation of response to DNA damage stimulus | 128/7958 | 219/18723 | 1.31e-06 | 1.90e-05 | 128 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:00718975 | Liver | HCC | DNA biosynthetic process | 99/7958 | 180/18723 | 4.66e-04 | 3.08e-03 | 99 |
GO:003239211 | Liver | HCC | DNA geometric change | 54/7958 | 90/18723 | 6.04e-04 | 3.79e-03 | 54 |
GO:00062824 | Liver | HCC | regulation of DNA repair | 74/7958 | 130/18723 | 6.27e-04 | 3.89e-03 | 74 |
GO:00325081 | Liver | HCC | DNA duplex unwinding | 49/7958 | 84/18723 | 2.46e-03 | 1.19e-02 | 49 |
GO:00062751 | Liver | HCC | regulation of DNA replication | 60/7958 | 107/18723 | 3.15e-03 | 1.46e-02 | 60 |
GO:0006261 | Liver | HCC | DNA-dependent DNA replication | 80/7958 | 151/18723 | 5.91e-03 | 2.44e-02 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WRNIP1 | SNV | Missense_Mutation | novel | c.1060N>T | p.Gly354Trp | p.G354W | Q96S55 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
WRNIP1 | SNV | Missense_Mutation | novel | c.1585G>A | p.Gly529Arg | p.G529R | Q96S55 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
WRNIP1 | SNV | Missense_Mutation | c.1004A>C | p.Lys335Thr | p.K335T | Q96S55 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WRNIP1 | SNV | Missense_Mutation | c.1871G>A | p.Arg624Lys | p.R624K | Q96S55 | protein_coding | tolerated(0.83) | benign(0.023) | TCGA-E2-A10A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | zoladex | SD | |
WRNIP1 | SNV | Missense_Mutation | novel | c.1054N>G | p.Leu352Val | p.L352V | Q96S55 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WRNIP1 | SNV | Missense_Mutation | rs369024379 | c.1861N>A | p.Ala621Thr | p.A621T | Q96S55 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
WRNIP1 | SNV | Missense_Mutation | c.878N>C | p.Val293Ala | p.V293A | Q96S55 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WRNIP1 | SNV | Missense_Mutation | rs757603585 | c.1318N>A | p.Ala440Thr | p.A440T | Q96S55 | protein_coding | deleterious(0) | possibly_damaging(0.76) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
WRNIP1 | SNV | Missense_Mutation | rs761279595 | c.1786G>A | p.Ala596Thr | p.A596T | Q96S55 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-G4-6627-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
WRNIP1 | SNV | Missense_Mutation | c.1130N>C | p.Leu377Pro | p.L377P | Q96S55 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0GA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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