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Gene: WDR27 |
Gene summary for WDR27 |
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Gene information | Species | Human | Gene symbol | WDR27 | Gene ID | 253769 |
Gene name | WD repeat domain 27 | |
Gene Alias | WDR27 | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A2RRH5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
253769 | WDR27 | A015-C-005 | Human | Colorectum | FAP | 5.04e-04 | -1.17e-01 | -0.0336 |
253769 | WDR27 | A015-C-006 | Human | Colorectum | FAP | 2.70e-14 | -2.88e-01 | -0.0994 |
253769 | WDR27 | A015-C-106 | Human | Colorectum | FAP | 2.06e-02 | -1.45e-01 | -0.0511 |
253769 | WDR27 | A002-C-114 | Human | Colorectum | FAP | 3.94e-18 | -3.48e-01 | -0.1561 |
253769 | WDR27 | A015-C-104 | Human | Colorectum | FAP | 5.56e-14 | -2.45e-01 | -0.1899 |
253769 | WDR27 | A001-C-014 | Human | Colorectum | FAP | 1.27e-05 | -2.85e-01 | 0.0135 |
253769 | WDR27 | A002-C-016 | Human | Colorectum | FAP | 3.32e-12 | -2.89e-01 | 0.0521 |
253769 | WDR27 | A015-C-002 | Human | Colorectum | FAP | 2.17e-10 | -3.36e-01 | -0.0763 |
253769 | WDR27 | A001-C-203 | Human | Colorectum | FAP | 4.59e-03 | -8.21e-02 | -0.0481 |
253769 | WDR27 | A002-C-116 | Human | Colorectum | FAP | 2.21e-21 | -4.28e-01 | -0.0452 |
253769 | WDR27 | A014-C-008 | Human | Colorectum | FAP | 9.75e-12 | -1.49e-01 | -0.191 |
253769 | WDR27 | A018-E-020 | Human | Colorectum | FAP | 6.41e-16 | -1.71e-01 | -0.2034 |
253769 | WDR27 | F034 | Human | Colorectum | FAP | 7.58e-08 | -1.83e-01 | -0.0665 |
253769 | WDR27 | F072B | Human | Colorectum | FAP | 5.66e-03 | -2.71e-01 | 0.257 |
253769 | WDR27 | CRC-3-11773 | Human | Colorectum | CRC | 3.55e-07 | -3.66e-01 | 0.2564 |
253769 | WDR27 | LZE4T | Human | Esophagus | ESCC | 9.34e-08 | 1.47e-01 | 0.0811 |
253769 | WDR27 | LZE7T | Human | Esophagus | ESCC | 8.16e-07 | 2.48e-01 | 0.0667 |
253769 | WDR27 | LZE24T | Human | Esophagus | ESCC | 1.10e-04 | 1.56e-01 | 0.0596 |
253769 | WDR27 | P1T-E | Human | Esophagus | ESCC | 2.03e-04 | 2.05e-01 | 0.0875 |
253769 | WDR27 | P2T-E | Human | Esophagus | ESCC | 2.98e-11 | 1.44e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR27 | SNV | Missense_Mutation | novel | c.1472N>T | p.Ser491Leu | p.S491L | A2RRH5 | protein_coding | tolerated(0.11) | benign(0.104) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR27 | SNV | Missense_Mutation | c.412N>T | p.Val138Phe | p.V138F | A2RRH5 | protein_coding | deleterious(0) | possibly_damaging(0.595) | TCGA-D8-A1JM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | ChemotherapyHormone Therapy | doxorubicine | SD | |
WDR27 | SNV | Missense_Mutation | novel | c.1618G>A | p.Ala540Thr | p.A540T | A2RRH5 | protein_coding | tolerated(0.29) | possibly_damaging(0.573) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR27 | SNV | Missense_Mutation | rs377380907 | c.1081G>A | p.Val361Ile | p.V361I | A2RRH5 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR27 | SNV | Missense_Mutation | novel | c.739N>A | p.Asp247Asn | p.D247N | A2RRH5 | protein_coding | tolerated(0.12) | benign(0.111) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WDR27 | SNV | Missense_Mutation | c.2211N>G | p.Ile737Met | p.I737M | A2RRH5 | protein_coding | deleterious(0) | benign(0.329) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
WDR27 | SNV | Missense_Mutation | c.1745C>T | p.Ser582Leu | p.S582L | A2RRH5 | protein_coding | deleterious(0.04) | possibly_damaging(0.744) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
WDR27 | insertion | In_Frame_Ins | novel | c.50_51insATATTTTTCTCC | p.Asp17delinsGluTyrPheSerPro | p.D17delinsEYFSP | A2RRH5 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
WDR27 | SNV | Missense_Mutation | novel | c.1147A>C | p.Ile383Leu | p.I383L | A2RRH5 | protein_coding | deleterious(0.01) | possibly_damaging(0.606) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WDR27 | SNV | Missense_Mutation | rs370224643 | c.2465N>A | p.Arg822Gln | p.R822Q | A2RRH5 | protein_coding | deleterious(0.01) | possibly_damaging(0.806) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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