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Gene: WDR12 |
Gene summary for WDR12 |
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Gene information | Species | Human | Gene symbol | WDR12 | Gene ID | 55759 |
Gene name | WD repeat domain 12 | |
Gene Alias | YTM1 | |
Cytomap | 2q33.2 | |
Gene Type | protein-coding | GO ID | GO:0000460 | UniProtAcc | Q53T99 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55759 | WDR12 | P24T-E | Human | Esophagus | ESCC | 4.57e-15 | 3.21e-01 | 0.1287 |
55759 | WDR12 | P26T-E | Human | Esophagus | ESCC | 6.80e-17 | 3.04e-01 | 0.1276 |
55759 | WDR12 | P27T-E | Human | Esophagus | ESCC | 9.69e-15 | 2.47e-01 | 0.1055 |
55759 | WDR12 | P28T-E | Human | Esophagus | ESCC | 1.20e-15 | 2.71e-01 | 0.1149 |
55759 | WDR12 | P30T-E | Human | Esophagus | ESCC | 3.29e-17 | 5.34e-01 | 0.137 |
55759 | WDR12 | P31T-E | Human | Esophagus | ESCC | 7.00e-18 | 3.26e-01 | 0.1251 |
55759 | WDR12 | P32T-E | Human | Esophagus | ESCC | 2.09e-24 | 5.60e-01 | 0.1666 |
55759 | WDR12 | P36T-E | Human | Esophagus | ESCC | 5.03e-16 | 3.58e-01 | 0.1187 |
55759 | WDR12 | P37T-E | Human | Esophagus | ESCC | 5.41e-17 | 3.01e-01 | 0.1371 |
55759 | WDR12 | P39T-E | Human | Esophagus | ESCC | 1.37e-19 | 2.91e-01 | 0.0894 |
55759 | WDR12 | P40T-E | Human | Esophagus | ESCC | 1.44e-05 | 9.61e-02 | 0.109 |
55759 | WDR12 | P42T-E | Human | Esophagus | ESCC | 6.56e-11 | 4.56e-01 | 0.1175 |
55759 | WDR12 | P44T-E | Human | Esophagus | ESCC | 1.21e-03 | 1.17e-01 | 0.1096 |
55759 | WDR12 | P47T-E | Human | Esophagus | ESCC | 1.33e-07 | 4.33e-02 | 0.1067 |
55759 | WDR12 | P48T-E | Human | Esophagus | ESCC | 1.08e-09 | 1.77e-01 | 0.0959 |
55759 | WDR12 | P49T-E | Human | Esophagus | ESCC | 8.78e-05 | 6.61e-01 | 0.1768 |
55759 | WDR12 | P52T-E | Human | Esophagus | ESCC | 2.76e-28 | 5.65e-01 | 0.1555 |
55759 | WDR12 | P54T-E | Human | Esophagus | ESCC | 4.94e-38 | 8.90e-01 | 0.0975 |
55759 | WDR12 | P56T-E | Human | Esophagus | ESCC | 4.84e-08 | 9.20e-01 | 0.1613 |
55759 | WDR12 | P57T-E | Human | Esophagus | ESCC | 1.86e-11 | 1.33e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042273111 | Esophagus | ESCC | ribosomal large subunit biogenesis | 65/8552 | 72/18723 | 1.53e-15 | 9.82e-14 | 65 |
GO:000047016 | Esophagus | ESCC | maturation of LSU-rRNA | 27/8552 | 28/18723 | 9.94e-09 | 2.00e-07 | 27 |
GO:00004603 | Esophagus | ESCC | maturation of 5.8S rRNA | 30/8552 | 35/18723 | 1.07e-06 | 1.34e-05 | 30 |
GO:00004634 | Esophagus | ESCC | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 15/8552 | 15/18723 | 7.81e-06 | 7.69e-05 | 15 |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
GO:00004663 | Esophagus | ESCC | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 21/8552 | 24/18723 | 2.57e-05 | 2.17e-04 | 21 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:004227322 | Liver | HCC | ribosomal large subunit biogenesis | 64/7958 | 72/18723 | 2.31e-16 | 2.03e-14 | 64 |
GO:000047011 | Liver | HCC | maturation of LSU-rRNA | 26/7958 | 28/18723 | 2.82e-08 | 6.43e-07 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR12 | SNV | Missense_Mutation | c.154G>C | p.Glu52Gln | p.E52Q | Q9GZL7 | protein_coding | deleterious(0.03) | possibly_damaging(0.784) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
WDR12 | SNV | Missense_Mutation | novel | c.236A>G | p.Glu79Gly | p.E79G | Q9GZL7 | protein_coding | tolerated(0.12) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR12 | SNV | Missense_Mutation | c.645C>G | p.Ile215Met | p.I215M | Q9GZL7 | protein_coding | deleterious(0) | possibly_damaging(0.891) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
WDR12 | SNV | Missense_Mutation | rs145165057 | c.419N>T | p.Thr140Met | p.T140M | Q9GZL7 | protein_coding | deleterious(0.04) | benign(0.397) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR12 | SNV | Missense_Mutation | novel | c.514N>C | p.Trp172Arg | p.W172R | Q9GZL7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
WDR12 | SNV | Missense_Mutation | novel | c.1262T>C | p.Val421Ala | p.V421A | Q9GZL7 | protein_coding | tolerated_low_confidence(0.48) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR12 | SNV | Missense_Mutation | novel | c.1118N>T | p.Arg373Ile | p.R373I | Q9GZL7 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR12 | SNV | Missense_Mutation | rs767414812 | c.895G>A | p.Val299Met | p.V299M | Q9GZL7 | protein_coding | deleterious(0.04) | possibly_damaging(0.9) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR12 | SNV | Missense_Mutation | c.246N>C | p.Glu82Asp | p.E82D | Q9GZL7 | protein_coding | tolerated(0.29) | benign(0.012) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
WDR12 | SNV | Missense_Mutation | c.536N>G | p.Val179Gly | p.V179G | Q9GZL7 | protein_coding | deleterious(0) | benign(0.129) | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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