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Gene: USP53 |
Gene summary for USP53 |
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Gene information | Species | Human | Gene symbol | USP53 | Gene ID | 54532 |
Gene name | ubiquitin specific peptidase 53 | |
Gene Alias | USP53 | |
Cytomap | 4q26 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | Q70EK8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54532 | USP53 | GSM4909319 | Human | Breast | IDC | 1.03e-19 | -3.97e-01 | 0.1563 |
54532 | USP53 | GSM4909320 | Human | Breast | IDC | 3.79e-05 | -4.10e-01 | 0.1575 |
54532 | USP53 | GSM4909321 | Human | Breast | IDC | 1.56e-15 | -4.54e-01 | 0.1559 |
54532 | USP53 | ctrl6 | Human | Breast | Precancer | 9.23e-16 | 8.20e-01 | -0.0061 |
54532 | USP53 | brca3 | Human | Breast | Precancer | 4.73e-05 | 3.06e-01 | -0.0263 |
54532 | USP53 | brca10 | Human | Breast | Precancer | 1.05e-07 | 5.64e-01 | -0.0029 |
54532 | USP53 | M2 | Human | Breast | IDC | 4.90e-02 | -4.03e-01 | 0.21 |
54532 | USP53 | NCCBC11 | Human | Breast | DCIS | 3.76e-02 | -4.38e-01 | 0.1232 |
54532 | USP53 | NCCBC14 | Human | Breast | DCIS | 1.58e-07 | -2.75e-01 | 0.2021 |
54532 | USP53 | NCCBC5 | Human | Breast | DCIS | 8.40e-12 | -4.24e-01 | 0.2046 |
54532 | USP53 | P1 | Human | Breast | IDC | 4.04e-08 | -2.98e-01 | 0.1527 |
54532 | USP53 | P2 | Human | Breast | IDC | 9.34e-07 | -3.99e-01 | 0.21 |
54532 | USP53 | DCIS2 | Human | Breast | DCIS | 2.90e-48 | 7.02e-01 | 0.0085 |
54532 | USP53 | CCI_1 | Human | Cervix | CC | 1.02e-03 | 1.20e+00 | 0.528 |
54532 | USP53 | CCI_2 | Human | Cervix | CC | 5.53e-03 | 1.02e+00 | 0.5249 |
54532 | USP53 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.07e-24 | -7.54e-01 | 0.0155 |
54532 | USP53 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.87e-17 | 7.45e-01 | -0.1954 |
54532 | USP53 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.27e-05 | 1.01e+00 | -0.2602 |
54532 | USP53 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.02e-16 | -7.52e-01 | 0.096 |
54532 | USP53 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.65e-03 | -8.07e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:00096126 | Breast | Precancer | response to mechanical stimulus | 23/1080 | 216/18723 | 3.41e-03 | 2.85e-02 | 23 |
GO:007099714 | Breast | IDC | neuron death | 57/1434 | 361/18723 | 1.31e-07 | 7.38e-06 | 57 |
GO:005140213 | Breast | IDC | neuron apoptotic process | 42/1434 | 246/18723 | 7.21e-07 | 3.35e-05 | 42 |
GO:000961211 | Breast | IDC | response to mechanical stimulus | 34/1434 | 216/18723 | 4.59e-05 | 1.03e-03 | 34 |
GO:00423912 | Breast | IDC | regulation of membrane potential | 49/1434 | 434/18723 | 4.04e-03 | 3.25e-02 | 49 |
GO:00015082 | Breast | IDC | action potential | 19/1434 | 134/18723 | 6.62e-03 | 4.62e-02 | 19 |
GO:007099724 | Breast | DCIS | neuron death | 57/1390 | 361/18723 | 4.56e-08 | 2.84e-06 | 57 |
GO:005140222 | Breast | DCIS | neuron apoptotic process | 43/1390 | 246/18723 | 1.16e-07 | 6.13e-06 | 43 |
GO:000961221 | Breast | DCIS | response to mechanical stimulus | 32/1390 | 216/18723 | 1.36e-04 | 2.33e-03 | 32 |
GO:00423911 | Breast | DCIS | regulation of membrane potential | 47/1390 | 434/18723 | 5.87e-03 | 4.20e-02 | 47 |
GO:00096127 | Cervix | CC | response to mechanical stimulus | 48/2311 | 216/18723 | 3.23e-05 | 5.29e-04 | 48 |
GO:007099710 | Cervix | CC | neuron death | 70/2311 | 361/18723 | 7.50e-05 | 1.03e-03 | 70 |
GO:005140210 | Cervix | CC | neuron apoptotic process | 49/2311 | 246/18723 | 4.48e-04 | 4.48e-03 | 49 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
GO:00709971 | Colorectum | SER | neuron death | 84/2897 | 361/18723 | 5.76e-05 | 1.35e-03 | 84 |
GO:00514021 | Colorectum | SER | neuron apoptotic process | 60/2897 | 246/18723 | 1.65e-04 | 3.13e-03 | 60 |
GO:00709972 | Colorectum | MSS | neuron death | 97/3467 | 361/18723 | 5.21e-05 | 9.31e-04 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP53 | SNV | Missense_Mutation | novel | c.268N>A | p.Glu90Lys | p.E90K | Q70EK8 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-5T-A9QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
USP53 | SNV | Missense_Mutation | novel | c.671N>T | p.Cys224Phe | p.C224F | Q70EK8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A8OQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP53 | SNV | Missense_Mutation | c.383N>C | p.Leu128Ser | p.L128S | Q70EK8 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
USP53 | SNV | Missense_Mutation | c.1505N>G | p.His502Arg | p.H502R | Q70EK8 | protein_coding | tolerated(0.19) | benign(0.024) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
USP53 | SNV | Missense_Mutation | c.884N>A | p.Ile295Asn | p.I295N | Q70EK8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A0TR-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
USP53 | SNV | Missense_Mutation | c.1348C>G | p.Leu450Val | p.L450V | Q70EK8 | protein_coding | tolerated(0.21) | benign(0.039) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
USP53 | SNV | Missense_Mutation | rs749089898 | c.2362G>A | p.Glu788Lys | p.E788K | Q70EK8 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.551) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
USP53 | SNV | Missense_Mutation | c.2780N>T | p.Lys927Met | p.K927M | Q70EK8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-D8-A1Y0-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide+methotrexatum+fluorouracillum | SD | |
USP53 | SNV | Missense_Mutation | rs766783806 | c.2210G>A | p.Arg737His | p.R737H | Q70EK8 | protein_coding | tolerated_low_confidence(0.66) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
USP53 | SNV | Missense_Mutation | c.310N>A | p.Glu104Lys | p.E104K | Q70EK8 | protein_coding | tolerated(0.22) | possibly_damaging(0.759) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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