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Gene: USP32 |
Gene summary for USP32 |
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Gene information | Species | Human | Gene symbol | USP32 | Gene ID | 84669 |
Gene name | ubiquitin specific peptidase 32 | |
Gene Alias | NY-REN-60 | |
Cytomap | 17q23.1-q23.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NFA0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84669 | USP32 | A015-C-005 | Human | Colorectum | FAP | 5.99e-03 | -1.60e-01 | -0.0336 |
84669 | USP32 | A015-C-006 | Human | Colorectum | FAP | 3.71e-13 | -4.46e-01 | -0.0994 |
84669 | USP32 | A015-C-106 | Human | Colorectum | FAP | 1.70e-14 | -2.54e-01 | -0.0511 |
84669 | USP32 | A002-C-114 | Human | Colorectum | FAP | 5.98e-16 | -3.64e-01 | -0.1561 |
84669 | USP32 | A015-C-104 | Human | Colorectum | FAP | 7.68e-26 | -2.91e-01 | -0.1899 |
84669 | USP32 | A001-C-014 | Human | Colorectum | FAP | 4.90e-15 | -3.01e-01 | 0.0135 |
84669 | USP32 | A002-C-016 | Human | Colorectum | FAP | 3.53e-21 | -3.59e-01 | 0.0521 |
84669 | USP32 | A015-C-002 | Human | Colorectum | FAP | 4.07e-10 | -4.60e-01 | -0.0763 |
84669 | USP32 | A001-C-203 | Human | Colorectum | FAP | 2.08e-11 | -1.68e-01 | -0.0481 |
84669 | USP32 | A002-C-116 | Human | Colorectum | FAP | 1.03e-31 | -3.41e-01 | -0.0452 |
84669 | USP32 | A014-C-008 | Human | Colorectum | FAP | 4.42e-12 | -3.40e-01 | -0.191 |
84669 | USP32 | A018-E-020 | Human | Colorectum | FAP | 4.26e-16 | -3.61e-01 | -0.2034 |
84669 | USP32 | F034 | Human | Colorectum | FAP | 3.02e-16 | -2.29e-01 | -0.0665 |
84669 | USP32 | F072B | Human | Colorectum | FAP | 1.25e-08 | -2.75e-01 | 0.257 |
84669 | USP32 | CRC-1-8810 | Human | Colorectum | CRC | 5.15e-05 | -2.82e-01 | 0.6257 |
84669 | USP32 | CRC-3-11773 | Human | Colorectum | CRC | 3.22e-08 | -1.84e-01 | 0.2564 |
84669 | USP32 | AEH-subject1 | Human | Endometrium | AEH | 5.35e-13 | 4.00e-01 | -0.3059 |
84669 | USP32 | AEH-subject3 | Human | Endometrium | AEH | 5.65e-08 | 3.45e-01 | -0.2576 |
84669 | USP32 | AEH-subject4 | Human | Endometrium | AEH | 2.13e-05 | 3.68e-01 | -0.2657 |
84669 | USP32 | AEH-subject5 | Human | Endometrium | AEH | 5.40e-14 | 4.78e-01 | -0.2953 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:0070646 | Liver | NAFLD | protein modification by small protein removal | 29/1882 | 157/18723 | 9.11e-04 | 1.09e-02 | 29 |
GO:0016579 | Liver | NAFLD | protein deubiquitination | 26/1882 | 139/18723 | 1.35e-03 | 1.52e-02 | 26 |
GO:00706461 | Liver | HCC | protein modification by small protein removal | 91/7958 | 157/18723 | 6.50e-05 | 5.92e-04 | 91 |
GO:00165791 | Liver | HCC | protein deubiquitination | 78/7958 | 139/18723 | 8.13e-04 | 4.87e-03 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP32 | SNV | Missense_Mutation | novel | c.829G>A | p.Asp277Asn | p.D277N | Q8NFA0 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-3C-AALK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
USP32 | SNV | Missense_Mutation | c.1672N>C | p.Asp558His | p.D558H | Q8NFA0 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
USP32 | SNV | Missense_Mutation | rs138623701 | c.590N>C | p.Ile197Thr | p.I197T | Q8NFA0 | protein_coding | tolerated(0.19) | benign(0.158) | TCGA-A7-A26E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | SD |
USP32 | SNV | Missense_Mutation | c.40N>A | p.Glu14Lys | p.E14K | Q8NFA0 | protein_coding | deleterious(0.01) | benign(0.005) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
USP32 | SNV | Missense_Mutation | novel | c.2146N>G | p.Ile716Val | p.I716V | Q8NFA0 | protein_coding | deleterious(0.03) | benign(0.063) | TCGA-AC-A3YJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
USP32 | SNV | Missense_Mutation | rs755492407 | c.4049N>T | p.Ser1350Leu | p.S1350L | Q8NFA0 | protein_coding | tolerated_low_confidence(0.28) | benign(0.015) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | novel | c.2308N>A | p.Glu770Lys | p.E770K | Q8NFA0 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-AO-A03P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | PD |
USP32 | SNV | Missense_Mutation | c.3878N>C | p.Ile1293Thr | p.I1293T | Q8NFA0 | protein_coding | deleterious(0) | possibly_damaging(0.696) | TCGA-B6-A1KF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
USP32 | SNV | Missense_Mutation | rs768752626 | c.1883C>T | p.Pro628Leu | p.P628L | Q8NFA0 | protein_coding | tolerated(0.06) | benign(0.048) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
USP32 | SNV | Missense_Mutation | c.4510N>G | p.Thr1504Ala | p.T1504A | Q8NFA0 | protein_coding | tolerated_low_confidence(0.46) | benign(0.006) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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