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Gene: USP31 |
Gene summary for USP31 |
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Gene information | Species | Human | Gene symbol | USP31 | Gene ID | 57478 |
Gene name | ubiquitin specific peptidase 31 | |
Gene Alias | USP31 | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q70CQ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57478 | USP31 | P26T-E | Human | Esophagus | ESCC | 2.60e-27 | 4.11e-01 | 0.1276 |
57478 | USP31 | P27T-E | Human | Esophagus | ESCC | 3.07e-09 | 1.25e-01 | 0.1055 |
57478 | USP31 | P28T-E | Human | Esophagus | ESCC | 2.60e-14 | 2.83e-01 | 0.1149 |
57478 | USP31 | P30T-E | Human | Esophagus | ESCC | 1.59e-28 | 9.48e-01 | 0.137 |
57478 | USP31 | P31T-E | Human | Esophagus | ESCC | 1.31e-15 | 2.62e-01 | 0.1251 |
57478 | USP31 | P32T-E | Human | Esophagus | ESCC | 2.95e-10 | 2.03e-01 | 0.1666 |
57478 | USP31 | P36T-E | Human | Esophagus | ESCC | 1.84e-11 | 4.20e-01 | 0.1187 |
57478 | USP31 | P37T-E | Human | Esophagus | ESCC | 9.75e-19 | 3.51e-01 | 0.1371 |
57478 | USP31 | P39T-E | Human | Esophagus | ESCC | 7.29e-05 | 8.88e-02 | 0.0894 |
57478 | USP31 | P40T-E | Human | Esophagus | ESCC | 2.14e-06 | 2.36e-01 | 0.109 |
57478 | USP31 | P42T-E | Human | Esophagus | ESCC | 3.56e-09 | 2.53e-01 | 0.1175 |
57478 | USP31 | P44T-E | Human | Esophagus | ESCC | 9.72e-03 | 1.29e-01 | 0.1096 |
57478 | USP31 | P47T-E | Human | Esophagus | ESCC | 8.92e-20 | 3.70e-01 | 0.1067 |
57478 | USP31 | P48T-E | Human | Esophagus | ESCC | 8.02e-16 | 2.78e-01 | 0.0959 |
57478 | USP31 | P52T-E | Human | Esophagus | ESCC | 1.62e-20 | 3.38e-01 | 0.1555 |
57478 | USP31 | P54T-E | Human | Esophagus | ESCC | 1.11e-11 | 2.73e-01 | 0.0975 |
57478 | USP31 | P57T-E | Human | Esophagus | ESCC | 2.09e-03 | 1.27e-01 | 0.0926 |
57478 | USP31 | P61T-E | Human | Esophagus | ESCC | 1.60e-14 | 4.76e-01 | 0.099 |
57478 | USP31 | P62T-E | Human | Esophagus | ESCC | 2.21e-18 | 3.87e-01 | 0.1302 |
57478 | USP31 | P65T-E | Human | Esophagus | ESCC | 1.60e-12 | 3.04e-01 | 0.0978 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:00706462 | Oral cavity | OSCC | protein modification by small protein removal | 77/7305 | 157/18723 | 6.55e-03 | 2.43e-02 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP31 | SNV | Missense_Mutation | c.2254G>T | p.Val752Phe | p.V752F | Q70CQ4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A06Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | PD | |
USP31 | SNV | Missense_Mutation | c.2597N>T | p.Ser866Leu | p.S866L | Q70CQ4 | protein_coding | tolerated(0.06) | benign(0.009) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
USP31 | SNV | Missense_Mutation | c.2309N>T | p.Ser770Leu | p.S770L | Q70CQ4 | protein_coding | deleterious(0.03) | probably_damaging(0.983) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
USP31 | SNV | Missense_Mutation | novel | c.2380N>T | p.Pro794Ser | p.P794S | Q70CQ4 | protein_coding | tolerated(0.22) | possibly_damaging(0.841) | TCGA-AC-A62Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP31 | SNV | Missense_Mutation | novel | c.2504G>A | p.Arg835Gln | p.R835Q | Q70CQ4 | protein_coding | deleterious(0.01) | benign(0.049) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP31 | SNV | Missense_Mutation | c.1337N>T | p.Ser446Phe | p.S446F | Q70CQ4 | protein_coding | tolerated(0.19) | benign(0.066) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
USP31 | SNV | Missense_Mutation | c.1751G>A | p.Arg584His | p.R584H | Q70CQ4 | protein_coding | deleterious(0.02) | probably_damaging(0.961) | TCGA-E2-A14T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
USP31 | insertion | Frame_Shift_Ins | novel | c.1063_1064insATGCTCCTGTGAACATTCCACACAAGTTTTTGTGTGG | p.Met355AsnfsTer20 | p.M355Nfs*20 | Q70CQ4 | protein_coding | TCGA-A8-A0A2-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
USP31 | deletion | Frame_Shift_Del | novel | c.2458delG | p.Glu820ArgfsTer2 | p.E820Rfs*2 | Q70CQ4 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
USP31 | deletion | Frame_Shift_Del | novel | c.2138delG | p.Cys713SerfsTer78 | p.C713Sfs*78 | Q70CQ4 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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