![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: USP21 |
Gene summary for USP21 |
![]() |
Gene information | Species | Human | Gene symbol | USP21 | Gene ID | 27005 |
Gene name | ubiquitin specific peptidase 21 | |
Gene Alias | USP16 | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9UK80 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27005 | USP21 | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 3.08e-01 | 0.1662 |
27005 | USP21 | P20T-E | Human | Esophagus | ESCC | 3.16e-23 | 4.06e-01 | 0.1124 |
27005 | USP21 | P21T-E | Human | Esophagus | ESCC | 5.74e-20 | 3.26e-01 | 0.1617 |
27005 | USP21 | P22T-E | Human | Esophagus | ESCC | 8.61e-18 | 1.73e-01 | 0.1236 |
27005 | USP21 | P23T-E | Human | Esophagus | ESCC | 2.12e-16 | 3.45e-01 | 0.108 |
27005 | USP21 | P24T-E | Human | Esophagus | ESCC | 8.49e-10 | 1.29e-01 | 0.1287 |
27005 | USP21 | P26T-E | Human | Esophagus | ESCC | 3.17e-17 | 2.50e-01 | 0.1276 |
27005 | USP21 | P27T-E | Human | Esophagus | ESCC | 8.81e-24 | 2.41e-01 | 0.1055 |
27005 | USP21 | P28T-E | Human | Esophagus | ESCC | 1.16e-16 | 3.11e-01 | 0.1149 |
27005 | USP21 | P30T-E | Human | Esophagus | ESCC | 1.16e-21 | 5.43e-01 | 0.137 |
27005 | USP21 | P31T-E | Human | Esophagus | ESCC | 2.19e-20 | 2.20e-01 | 0.1251 |
27005 | USP21 | P32T-E | Human | Esophagus | ESCC | 6.05e-15 | 2.42e-01 | 0.1666 |
27005 | USP21 | P36T-E | Human | Esophagus | ESCC | 9.86e-13 | 3.27e-01 | 0.1187 |
27005 | USP21 | P37T-E | Human | Esophagus | ESCC | 2.57e-08 | 1.47e-01 | 0.1371 |
27005 | USP21 | P39T-E | Human | Esophagus | ESCC | 8.16e-11 | 1.12e-01 | 0.0894 |
27005 | USP21 | P40T-E | Human | Esophagus | ESCC | 5.68e-07 | 1.76e-01 | 0.109 |
27005 | USP21 | P42T-E | Human | Esophagus | ESCC | 1.25e-11 | 2.53e-01 | 0.1175 |
27005 | USP21 | P44T-E | Human | Esophagus | ESCC | 6.93e-04 | 1.10e-01 | 0.1096 |
27005 | USP21 | P47T-E | Human | Esophagus | ESCC | 2.35e-12 | 1.05e-01 | 0.1067 |
27005 | USP21 | P48T-E | Human | Esophagus | ESCC | 2.73e-14 | 1.99e-01 | 0.0959 |
Page: 1 2 3 4 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00165708 | Esophagus | HGIN | histone modification | 92/2587 | 463/18723 | 1.70e-04 | 3.30e-03 | 92 |
GO:00706463 | Esophagus | HGIN | protein modification by small protein removal | 34/2587 | 157/18723 | 4.68e-03 | 4.02e-02 | 34 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00165783 | Esophagus | ESCC | histone deubiquitination | 18/8552 | 23/18723 | 1.50e-03 | 7.06e-03 | 18 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP21 | SNV | Missense_Mutation | c.1054G>T | p.Asp352Tyr | p.D352Y | Q9UK80 | protein_coding | deleterious(0) | possibly_damaging(0.583) | TCGA-AN-A0FV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
USP21 | SNV | Missense_Mutation | novel | c.181G>C | p.Glu61Gln | p.E61Q | Q9UK80 | protein_coding | deleterious_low_confidence(0.01) | benign(0.102) | TCGA-BH-A0DP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
USP21 | SNV | Missense_Mutation | c.790N>C | p.Asp264His | p.D264H | Q9UK80 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
USP21 | deletion | Frame_Shift_Del | novel | c.214_286delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Arg72GlnfsTer13 | p.R72Qfs*13 | Q9UK80 | protein_coding | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
USP21 | insertion | Frame_Shift_Ins | novel | c.536_537insGGGAGGGGTCGGGAGTATAGAAAGGGTCAAAG | p.His180GlyfsTer17 | p.H180Gfs*17 | Q9UK80 | protein_coding | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
USP21 | insertion | Nonsense_Mutation | novel | c.182_183insCATCCTACTTTACTAGCCGGGTATGGGGTCCC | p.Glu61AspfsTer6 | p.E61Dfs*6 | Q9UK80 | protein_coding | TCGA-BH-A0DP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
USP21 | SNV | Missense_Mutation | c.1057N>A | p.Asp353Asn | p.D353N | Q9UK80 | protein_coding | deleterious(0.01) | benign(0.093) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
USP21 | SNV | Missense_Mutation | rs760197993 | c.565N>T | p.Arg189Trp | p.R189W | Q9UK80 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
USP21 | SNV | Missense_Mutation | c.1381N>T | p.Leu461Phe | p.L461F | Q9UK80 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-EK-A2RO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
USP21 | SNV | Missense_Mutation | novel | c.555G>A | p.Met185Ile | p.M185I | Q9UK80 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-ZX-AA5X-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |