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Gene: UNKL |
Gene summary for UNKL |
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Gene information | Species | Human | Gene symbol | UNKL | Gene ID | 64718 |
Gene name | unk like zinc finger | |
Gene Alias | C16orf28 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9H9P5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64718 | UNKL | P28T-E | Human | Esophagus | ESCC | 5.49e-08 | 1.84e-01 | 0.1149 |
64718 | UNKL | P30T-E | Human | Esophagus | ESCC | 2.95e-13 | 4.66e-01 | 0.137 |
64718 | UNKL | P31T-E | Human | Esophagus | ESCC | 1.79e-08 | 1.22e-01 | 0.1251 |
64718 | UNKL | P32T-E | Human | Esophagus | ESCC | 8.15e-07 | 2.22e-01 | 0.1666 |
64718 | UNKL | P36T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.35e-01 | 0.1187 |
64718 | UNKL | P37T-E | Human | Esophagus | ESCC | 8.82e-10 | 1.50e-01 | 0.1371 |
64718 | UNKL | P39T-E | Human | Esophagus | ESCC | 1.45e-04 | 1.04e-01 | 0.0894 |
64718 | UNKL | P42T-E | Human | Esophagus | ESCC | 1.95e-05 | 1.04e-01 | 0.1175 |
64718 | UNKL | P44T-E | Human | Esophagus | ESCC | 3.18e-02 | 4.50e-02 | 0.1096 |
64718 | UNKL | P47T-E | Human | Esophagus | ESCC | 1.13e-06 | 1.08e-01 | 0.1067 |
64718 | UNKL | P48T-E | Human | Esophagus | ESCC | 7.92e-06 | 8.72e-02 | 0.0959 |
64718 | UNKL | P49T-E | Human | Esophagus | ESCC | 1.32e-09 | 8.17e-01 | 0.1768 |
64718 | UNKL | P52T-E | Human | Esophagus | ESCC | 1.39e-07 | 1.84e-01 | 0.1555 |
64718 | UNKL | P54T-E | Human | Esophagus | ESCC | 9.30e-07 | 6.95e-02 | 0.0975 |
64718 | UNKL | P56T-E | Human | Esophagus | ESCC | 1.85e-07 | 6.97e-01 | 0.1613 |
64718 | UNKL | P57T-E | Human | Esophagus | ESCC | 5.40e-06 | 9.08e-02 | 0.0926 |
64718 | UNKL | P61T-E | Human | Esophagus | ESCC | 5.69e-03 | 7.59e-02 | 0.099 |
64718 | UNKL | P62T-E | Human | Esophagus | ESCC | 1.19e-14 | 2.40e-01 | 0.1302 |
64718 | UNKL | P65T-E | Human | Esophagus | ESCC | 4.22e-02 | 4.53e-02 | 0.0978 |
64718 | UNKL | P74T-E | Human | Esophagus | ESCC | 1.12e-05 | 1.20e-01 | 0.1479 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UNKL | SNV | Missense_Mutation | novel | c.534N>C | p.Gln178His | p.Q178H | Q9H9P5 | protein_coding | deleterious_low_confidence(0) | benign(0.03) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
UNKL | SNV | Missense_Mutation | novel | c.814G>A | p.Gly272Arg | p.G272R | Q9H9P5 | protein_coding | probably_damaging(0.979) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
UNKL | SNV | Missense_Mutation | c.569N>C | p.Lys190Thr | p.K190T | Q9H9P5 | protein_coding | tolerated_low_confidence(0.07) | benign(0.09) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UNKL | SNV | Missense_Mutation | c.1579C>A | p.Pro527Thr | p.P527T | protein_coding | tolerated(0.05) | benign(0.024) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
UNKL | SNV | Missense_Mutation | rs574875280 | c.524C>T | p.Pro175Leu | p.P175L | Q9H9P5 | protein_coding | tolerated_low_confidence(0.22) | benign(0.149) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UNKL | SNV | Missense_Mutation | c.340N>T | p.Arg114Cys | p.R114C | Q9H9P5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
UNKL | SNV | Missense_Mutation | c.428N>A | p.Gly143Asp | p.G143D | Q9H9P5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
UNKL | SNV | Missense_Mutation | novel | c.1546N>A | p.Gly516Ser | p.G516S | protein_coding | tolerated(0.67) | benign(0.058) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
UNKL | SNV | Missense_Mutation | novel | c.535N>T | p.Pro179Ser | p.P179S | Q9H9P5 | protein_coding | tolerated_low_confidence(0.3) | benign(0.042) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNKL | SNV | Missense_Mutation | c.409N>T | p.His137Tyr | p.H137Y | Q9H9P5 | protein_coding | tolerated(0.12) | possibly_damaging(0.879) | TCGA-AP-A1DP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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