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Gene: UCHL1 |
Gene summary for UCHL1 |
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Gene information | Species | Human | Gene symbol | UCHL1 | Gene ID | 7345 |
Gene name | ubiquitin C-terminal hydrolase L1 | |
Gene Alias | HEL-117 | |
Cytomap | 4p13 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P09936 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7345 | UCHL1 | P30T-E | Human | Esophagus | ESCC | 1.14e-30 | 2.78e+00 | 0.137 |
7345 | UCHL1 | P32T-E | Human | Esophagus | ESCC | 7.62e-114 | 3.62e+00 | 0.1666 |
7345 | UCHL1 | P37T-E | Human | Esophagus | ESCC | 5.08e-38 | 1.79e+00 | 0.1371 |
7345 | UCHL1 | P38T-E | Human | Esophagus | ESCC | 2.58e-36 | 2.40e+00 | 0.127 |
7345 | UCHL1 | P39T-E | Human | Esophagus | ESCC | 6.83e-32 | 1.22e+00 | 0.0894 |
7345 | UCHL1 | P40T-E | Human | Esophagus | ESCC | 6.62e-11 | 8.95e-01 | 0.109 |
7345 | UCHL1 | P44T-E | Human | Esophagus | ESCC | 2.34e-06 | 5.79e-01 | 0.1096 |
7345 | UCHL1 | P47T-E | Human | Esophagus | ESCC | 9.95e-07 | 3.36e-01 | 0.1067 |
7345 | UCHL1 | P49T-E | Human | Esophagus | ESCC | 2.12e-20 | 3.45e+00 | 0.1768 |
7345 | UCHL1 | P52T-E | Human | Esophagus | ESCC | 1.27e-29 | 2.59e+00 | 0.1555 |
7345 | UCHL1 | P56T-E | Human | Esophagus | ESCC | 6.63e-15 | 4.06e+00 | 0.1613 |
7345 | UCHL1 | P61T-E | Human | Esophagus | ESCC | 1.20e-32 | 1.11e+00 | 0.099 |
7345 | UCHL1 | P65T-E | Human | Esophagus | ESCC | 2.47e-02 | 1.52e-01 | 0.0978 |
7345 | UCHL1 | P74T-E | Human | Esophagus | ESCC | 5.93e-52 | 2.37e+00 | 0.1479 |
7345 | UCHL1 | P76T-E | Human | Esophagus | ESCC | 2.95e-30 | 1.33e+00 | 0.1207 |
7345 | UCHL1 | P79T-E | Human | Esophagus | ESCC | 3.09e-41 | 1.26e+00 | 0.1154 |
7345 | UCHL1 | P80T-E | Human | Esophagus | ESCC | 9.30e-05 | 1.61e-01 | 0.155 |
7345 | UCHL1 | P83T-E | Human | Esophagus | ESCC | 2.50e-68 | 2.57e+00 | 0.1738 |
7345 | UCHL1 | P107T-E | Human | Esophagus | ESCC | 8.39e-110 | 4.83e+00 | 0.171 |
7345 | UCHL1 | P126T-E | Human | Esophagus | ESCC | 6.58e-03 | 5.63e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00719007 | Cervix | CC | regulation of protein serine/threonine kinase activity | 75/2311 | 359/18723 | 2.76e-06 | 8.02e-05 | 75 |
GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:000193310 | Cervix | CC | negative regulation of protein phosphorylation | 69/2311 | 342/18723 | 2.29e-05 | 4.01e-04 | 69 |
GO:00516567 | Cervix | CC | establishment of organelle localization | 76/2311 | 390/18723 | 3.17e-05 | 5.21e-04 | 76 |
GO:000646910 | Cervix | CC | negative regulation of protein kinase activity | 47/2311 | 212/18723 | 4.13e-05 | 6.36e-04 | 47 |
GO:00336739 | Cervix | CC | negative regulation of kinase activity | 50/2311 | 237/18723 | 9.22e-05 | 1.21e-03 | 50 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00162367 | Cervix | CC | macroautophagy | 58/2311 | 291/18723 | 1.40e-04 | 1.70e-03 | 58 |
GO:00105067 | Cervix | CC | regulation of autophagy | 61/2311 | 317/18723 | 2.61e-04 | 2.87e-03 | 61 |
GO:00307057 | Cervix | CC | cytoskeleton-dependent intracellular transport | 40/2311 | 195/18723 | 7.92e-04 | 6.99e-03 | 40 |
GO:00426924 | Cervix | CC | muscle cell differentiation | 69/2311 | 384/18723 | 8.12e-04 | 7.09e-03 | 69 |
GO:00434099 | Cervix | CC | negative regulation of MAPK cascade | 37/2311 | 180/18723 | 1.17e-03 | 9.50e-03 | 37 |
GO:00516541 | Cervix | CC | establishment of mitochondrion localization | 10/2311 | 29/18723 | 1.74e-03 | 1.31e-02 | 10 |
GO:00094109 | Cervix | CC | response to xenobiotic stimulus | 78/2311 | 462/18723 | 2.39e-03 | 1.70e-02 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0502219 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa05012211 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05012310 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501222 | Liver | HCC | Parkinson disease | 198/4020 | 266/8465 | 9.40e-20 | 1.58e-17 | 8.76e-18 | 198 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501232 | Liver | HCC | Parkinson disease | 198/4020 | 266/8465 | 9.40e-20 | 1.58e-17 | 8.76e-18 | 198 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501230 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
hsa0502228 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa05012113 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
hsa05022112 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa05012210 | Oral cavity | LP | Parkinson disease | 166/2418 | 266/8465 | 2.02e-31 | 3.36e-29 | 2.17e-29 | 166 |
hsa0502229 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
hsa0501238 | Oral cavity | LP | Parkinson disease | 166/2418 | 266/8465 | 2.02e-31 | 3.36e-29 | 2.17e-29 | 166 |
hsa0502237 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UCHL1 | SNV | Missense_Mutation | novel | c.31G>C | p.Glu11Gln | p.E11Q | P09936 | protein_coding | tolerated(0.07) | benign(0.037) | TCGA-Q1-A73R-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | rs139583787 | c.457C>T | p.Arg153Trp | p.R153W | P09936 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
UCHL1 | SNV | Missense_Mutation | rs770039881 | c.649N>A | p.Val217Met | p.V217M | P09936 | protein_coding | tolerated(0.13) | possibly_damaging(0.696) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | novel | c.466G>T | p.Asp156Tyr | p.D156Y | P09936 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
UCHL1 | SNV | Missense_Mutation | novel | c.420G>T | p.Gln140His | p.Q140H | P09936 | protein_coding | tolerated(0.54) | possibly_damaging(0.745) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | c.458G>A | p.Arg153Gln | p.R153Q | P09936 | protein_coding | tolerated(0.16) | possibly_damaging(0.753) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UCHL1 | SNV | Missense_Mutation | rs139583787 | c.457N>T | p.Arg153Trp | p.R153W | P09936 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | rs139583787 | c.457N>T | p.Arg153Trp | p.R153W | P09936 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | novel | c.522N>C | p.Glu174Asp | p.E174D | P09936 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UCHL1 | SNV | Missense_Mutation | novel | c.23T>C | p.Ile8Thr | p.I8T | P09936 | protein_coding | tolerated(0.28) | probably_damaging(0.992) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7345 | UCHL1 | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 252166861 |
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