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Gene: UBE2R2 |
Gene summary for UBE2R2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | UBE2R2 | Gene ID | 54926 |
Gene name | ubiquitin conjugating enzyme E2 R2 | |
Gene Alias | CDC34B | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q712K3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54926 | UBE2R2 | A015-C-106 | Human | Colorectum | FAP | 2.74e-08 | -2.48e-01 | -0.0511 |
54926 | UBE2R2 | A002-C-114 | Human | Colorectum | FAP | 5.41e-19 | -3.16e-01 | -0.1561 |
54926 | UBE2R2 | A015-C-104 | Human | Colorectum | FAP | 1.92e-23 | -3.83e-01 | -0.1899 |
54926 | UBE2R2 | A001-C-014 | Human | Colorectum | FAP | 2.99e-10 | -3.16e-01 | 0.0135 |
54926 | UBE2R2 | A002-C-016 | Human | Colorectum | FAP | 6.28e-18 | -2.33e-01 | 0.0521 |
54926 | UBE2R2 | A015-C-002 | Human | Colorectum | FAP | 1.29e-11 | -3.88e-01 | -0.0763 |
54926 | UBE2R2 | A001-C-203 | Human | Colorectum | FAP | 5.49e-08 | -1.66e-01 | -0.0481 |
54926 | UBE2R2 | A002-C-116 | Human | Colorectum | FAP | 1.17e-26 | -1.93e-01 | -0.0452 |
54926 | UBE2R2 | A014-C-008 | Human | Colorectum | FAP | 1.86e-11 | -3.90e-01 | -0.191 |
54926 | UBE2R2 | A018-E-020 | Human | Colorectum | FAP | 5.70e-19 | -4.17e-01 | -0.2034 |
54926 | UBE2R2 | F034 | Human | Colorectum | FAP | 3.99e-16 | -2.23e-01 | -0.0665 |
54926 | UBE2R2 | F072B | Human | Colorectum | FAP | 2.69e-06 | -2.25e-01 | 0.257 |
54926 | UBE2R2 | CRC-1-8810 | Human | Colorectum | CRC | 4.57e-04 | 2.72e-01 | 0.6257 |
54926 | UBE2R2 | CRC-3-11773 | Human | Colorectum | CRC | 5.30e-07 | 1.00e-01 | 0.2564 |
54926 | UBE2R2 | LZE4T | Human | Esophagus | ESCC | 2.61e-08 | 1.54e-01 | 0.0811 |
54926 | UBE2R2 | LZE5T | Human | Esophagus | ESCC | 1.27e-03 | 1.10e-01 | 0.0514 |
54926 | UBE2R2 | LZE7T | Human | Esophagus | ESCC | 1.23e-05 | 3.53e-01 | 0.0667 |
54926 | UBE2R2 | LZE8T | Human | Esophagus | ESCC | 1.59e-06 | 2.28e-02 | 0.067 |
54926 | UBE2R2 | LZE20T | Human | Esophagus | ESCC | 4.61e-04 | 1.85e-02 | 0.0662 |
54926 | UBE2R2 | LZE24T | Human | Esophagus | ESCC | 6.85e-11 | 3.66e-01 | 0.0596 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00002097 | Cervix | CC | protein polyubiquitination | 58/2311 | 236/18723 | 1.57e-07 | 7.41e-06 | 58 |
GO:00709366 | Cervix | CC | protein K48-linked ubiquitination | 22/2311 | 65/18723 | 5.56e-06 | 1.38e-04 | 22 |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:0070936 | Colorectum | AD | protein K48-linked ubiquitination | 27/3918 | 65/18723 | 1.31e-04 | 1.88e-03 | 27 |
GO:0006513 | Colorectum | AD | protein monoubiquitination | 23/3918 | 67/18723 | 7.55e-03 | 4.58e-02 | 23 |
GO:00002092 | Colorectum | MSS | protein polyubiquitination | 72/3467 | 236/18723 | 5.19e-06 | 1.42e-04 | 72 |
GO:00709361 | Colorectum | MSS | protein K48-linked ubiquitination | 27/3467 | 65/18723 | 1.40e-05 | 3.18e-04 | 27 |
GO:00065131 | Colorectum | MSS | protein monoubiquitination | 21/3467 | 67/18723 | 7.90e-03 | 4.84e-02 | 21 |
GO:00709362 | Colorectum | FAP | protein K48-linked ubiquitination | 24/2622 | 65/18723 | 3.42e-06 | 1.23e-04 | 24 |
GO:00002093 | Colorectum | FAP | protein polyubiquitination | 59/2622 | 236/18723 | 4.53e-06 | 1.52e-04 | 59 |
GO:00065132 | Colorectum | FAP | protein monoubiquitination | 18/2622 | 67/18723 | 4.08e-03 | 2.81e-02 | 18 |
GO:00709363 | Colorectum | CRC | protein K48-linked ubiquitination | 19/2078 | 65/18723 | 5.34e-05 | 1.22e-03 | 19 |
GO:00002094 | Colorectum | CRC | protein polyubiquitination | 46/2078 | 236/18723 | 9.91e-05 | 1.98e-03 | 46 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:007093617 | Esophagus | ESCC | protein K48-linked ubiquitination | 55/8552 | 65/18723 | 8.42e-11 | 2.58e-09 | 55 |
GO:00065136 | Esophagus | ESCC | protein monoubiquitination | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:00002095 | Liver | NAFLD | protein polyubiquitination | 51/1882 | 236/18723 | 1.04e-07 | 8.10e-06 | 51 |
GO:00709364 | Liver | NAFLD | protein K48-linked ubiquitination | 19/1882 | 65/18723 | 1.33e-05 | 3.97e-04 | 19 |
GO:007093611 | Liver | Cirrhotic | protein K48-linked ubiquitination | 36/4634 | 65/18723 | 1.23e-07 | 3.41e-06 | 36 |
GO:000020911 | Liver | Cirrhotic | protein polyubiquitination | 89/4634 | 236/18723 | 6.09e-06 | 9.80e-05 | 89 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041204 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa041205 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa041206 | Colorectum | FAP | Ubiquitin mediated proteolysis | 51/1404 | 142/8465 | 1.55e-08 | 5.84e-07 | 3.55e-07 | 51 |
hsa041207 | Colorectum | FAP | Ubiquitin mediated proteolysis | 51/1404 | 142/8465 | 1.55e-08 | 5.84e-07 | 3.55e-07 | 51 |
hsa041208 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa041209 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412010 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0412011 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0412021 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0412031 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412051 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412020 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa04120110 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE2R2 | SNV | Missense_Mutation | rs372565481 | c.603N>G | p.Asn201Lys | p.N201K | Q712K3 | protein_coding | tolerated(0.22) | benign(0.01) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
UBE2R2 | SNV | Missense_Mutation | c.334N>A | p.Glu112Lys | p.E112K | Q712K3 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
UBE2R2 | SNV | Missense_Mutation | novel | c.548T>C | p.Val183Ala | p.V183A | Q712K3 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
UBE2R2 | SNV | Missense_Mutation | c.622G>A | p.Asp208Asn | p.D208N | Q712K3 | protein_coding | tolerated(0.12) | probably_damaging(0.978) | TCGA-A6-3807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD | |
UBE2R2 | SNV | Missense_Mutation | novel | c.489N>C | p.Glu163Asp | p.E163D | Q712K3 | protein_coding | tolerated(0.87) | benign(0.006) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBE2R2 | SNV | Missense_Mutation | c.169T>C | p.Tyr57His | p.Y57H | Q712K3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBE2R2 | SNV | Missense_Mutation | novel | c.444N>A | p.Phe148Leu | p.F148L | Q712K3 | protein_coding | tolerated(0.1) | benign(0.309) | TCGA-D5-6537-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
UBE2R2 | SNV | Missense_Mutation | c.616C>A | p.Leu206Ile | p.L206I | Q712K3 | protein_coding | tolerated(0.18) | benign(0.042) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBE2R2 | SNV | Missense_Mutation | c.284N>T | p.Ser95Leu | p.S95L | Q712K3 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBE2R2 | SNV | Missense_Mutation | novel | c.563N>T | p.Ala188Val | p.A188V | Q712K3 | protein_coding | tolerated(0.07) | benign(0.428) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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