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Gene: UBE2L3 |
Gene summary for UBE2L3 |
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Gene information | Species | Human | Gene symbol | UBE2L3 | Gene ID | 7332 |
Gene name | ubiquitin conjugating enzyme E2 L3 | |
Gene Alias | E2-F1 | |
Cytomap | 22q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | P68036 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7332 | UBE2L3 | P2 | Human | Breast | IDC | 2.04e-08 | 4.02e-01 | 0.21 |
7332 | UBE2L3 | DCIS2 | Human | Breast | DCIS | 1.28e-56 | 1.35e-01 | 0.0085 |
7332 | UBE2L3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.17e-16 | 7.92e-01 | -0.1808 |
7332 | UBE2L3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.25e-13 | 8.12e-01 | -0.0811 |
7332 | UBE2L3 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.77e-26 | 6.87e-01 | -0.1954 |
7332 | UBE2L3 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.54e-04 | 9.38e-01 | -0.2602 |
7332 | UBE2L3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.17e-04 | 8.22e-01 | -0.2196 |
7332 | UBE2L3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.01e-05 | 5.65e-01 | -0.1207 |
7332 | UBE2L3 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.95e-04 | 4.60e-01 | -0.1526 |
7332 | UBE2L3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.79e-17 | 6.81e-01 | -0.1464 |
7332 | UBE2L3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.76e-02 | 4.00e-01 | -0.1001 |
7332 | UBE2L3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.57e-21 | 8.85e-01 | -0.059 |
7332 | UBE2L3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.59e-03 | 5.39e-01 | -0.1706 |
7332 | UBE2L3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.26e-04 | 6.18e-01 | -0.2061 |
7332 | UBE2L3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.12e-07 | 5.99e-01 | -0.0842 |
7332 | UBE2L3 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.23e-09 | 4.12e-01 | 0.096 |
7332 | UBE2L3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.06e-04 | 5.91e-01 | 0.0446 |
7332 | UBE2L3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.60e-02 | 2.61e-01 | 0.0338 |
7332 | UBE2L3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.69e-03 | 4.51e-01 | 0.0674 |
7332 | UBE2L3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.15e-10 | 5.75e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068398 | Breast | Precancer | mitochondrial transport | 45/1080 | 254/18723 | 1.37e-11 | 1.88e-09 | 45 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:19033209 | Breast | Precancer | regulation of protein modification by small protein conjugation or removal | 38/1080 | 242/18723 | 1.71e-08 | 1.17e-06 | 38 |
GO:00319608 | Breast | Precancer | response to corticosteroid | 30/1080 | 167/18723 | 2.50e-08 | 1.65e-06 | 30 |
GO:00313969 | Breast | Precancer | regulation of protein ubiquitination | 33/1080 | 210/18723 | 1.45e-07 | 7.82e-06 | 33 |
GO:00513848 | Breast | Precancer | response to glucocorticoid | 26/1080 | 148/18723 | 3.32e-07 | 1.57e-05 | 26 |
GO:00705858 | Breast | Precancer | protein localization to mitochondrion | 21/1080 | 125/18723 | 9.07e-06 | 2.42e-04 | 21 |
GO:00726558 | Breast | Precancer | establishment of protein localization to mitochondrion | 20/1080 | 120/18723 | 1.66e-05 | 4.03e-04 | 20 |
GO:00713838 | Breast | Precancer | cellular response to steroid hormone stimulus | 28/1080 | 204/18723 | 1.78e-05 | 4.26e-04 | 28 |
GO:19049519 | Breast | Precancer | positive regulation of establishment of protein localization | 36/1080 | 319/18723 | 9.30e-05 | 1.75e-03 | 36 |
GO:00066268 | Breast | Precancer | protein targeting to mitochondrion | 15/1080 | 100/18723 | 5.94e-04 | 7.48e-03 | 15 |
GO:19038299 | Breast | Precancer | positive regulation of cellular protein localization | 30/1080 | 276/18723 | 6.48e-04 | 7.99e-03 | 30 |
GO:00066059 | Breast | Precancer | protein targeting | 33/1080 | 314/18723 | 6.50e-04 | 7.99e-03 | 33 |
GO:00713846 | Breast | Precancer | cellular response to corticosteroid stimulus | 11/1080 | 61/18723 | 6.54e-04 | 8.01e-03 | 11 |
GO:00725948 | Breast | Precancer | establishment of protein localization to organelle | 41/1080 | 422/18723 | 7.75e-04 | 9.20e-03 | 41 |
GO:00514386 | Breast | Precancer | regulation of ubiquitin-protein transferase activity | 10/1080 | 53/18723 | 7.88e-04 | 9.29e-03 | 10 |
GO:00713856 | Breast | Precancer | cellular response to glucocorticoid stimulus | 10/1080 | 56/18723 | 1.23e-03 | 1.32e-02 | 10 |
GO:00512229 | Breast | Precancer | positive regulation of protein transport | 31/1080 | 303/18723 | 1.44e-03 | 1.50e-02 | 31 |
GO:19037474 | Breast | Precancer | regulation of establishment of protein localization to mitochondrion | 8/1080 | 50/18723 | 7.39e-03 | 4.90e-02 | 8 |
GO:004854514 | Breast | IDC | response to steroid hormone | 70/1434 | 339/18723 | 1.34e-14 | 4.23e-12 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502223 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0501234 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502233 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0501243 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0502243 | Breast | DCIS | Pathways of neurodegeneration - multiple diseases | 114/846 | 476/8465 | 4.74e-20 | 1.53e-18 | 1.13e-18 | 114 |
hsa0501253 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0502253 | Breast | DCIS | Pathways of neurodegeneration - multiple diseases | 114/846 | 476/8465 | 4.74e-20 | 1.53e-18 | 1.13e-18 | 114 |
hsa05012 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa050122 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE2L3 | SNV | Missense_Mutation | novel | c.240C>A | p.Phe80Leu | p.F80L | P68036 | protein_coding | tolerated(0.37) | benign(0.212) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBE2L3 | SNV | Missense_Mutation | c.317A>C | p.Lys106Thr | p.K106T | P68036 | protein_coding | tolerated(0.13) | probably_damaging(0.975) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UBE2L3 | SNV | Missense_Mutation | novel | c.374A>C | p.Lys125Thr | p.K125T | P68036 | protein_coding | tolerated(0.19) | possibly_damaging(0.823) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE2L3 | SNV | Missense_Mutation | c.271N>A | p.Leu91Met | p.L91M | P68036 | protein_coding | deleterious(0.04) | possibly_damaging(0.654) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
UBE2L3 | SNV | Missense_Mutation | novel | c.451N>A | p.Glu151Lys | p.E151K | P68036 | protein_coding | deleterious(0.04) | benign(0.193) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBE2L3 | deletion | In_Frame_Del | c.326_331delNNNNNN | p.Arg110_Ile111del | p.R110_I111del | P68036 | protein_coding | TCGA-CA-6715-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |||
UBE2L3 | SNV | Missense_Mutation | novel | c.571N>T | p.Arg191Cys | p.R191C | P68036 | protein_coding | tolerated(0.06) | benign(0.122) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE2L3 | SNV | Missense_Mutation | novel | c.609N>T | p.Lys203Asn | p.K203N | P68036 | protein_coding | deleterious(0.03) | possibly_damaging(0.736) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE2L3 | SNV | Missense_Mutation | novel | c.576N>C | p.Lys192Asn | p.K192N | P68036 | protein_coding | deleterious(0.04) | probably_damaging(0.917) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
UBE2L3 | insertion | Frame_Shift_Ins | novel | c.579dupA | p.Phe194IlefsTer3 | p.F194Ifs*3 | P68036 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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