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Gene: UBE2G2 |
Gene summary for UBE2G2 |
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Gene information | Species | Human | Gene symbol | UBE2G2 | Gene ID | 7327 |
Gene name | ubiquitin conjugating enzyme E2 G2 | |
Gene Alias | UBC7 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | P60604 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7327 | UBE2G2 | P22T-E | Human | Esophagus | ESCC | 1.03e-22 | 3.34e-01 | 0.1236 |
7327 | UBE2G2 | P23T-E | Human | Esophagus | ESCC | 2.36e-20 | 5.30e-01 | 0.108 |
7327 | UBE2G2 | P24T-E | Human | Esophagus | ESCC | 2.58e-19 | 3.93e-01 | 0.1287 |
7327 | UBE2G2 | P26T-E | Human | Esophagus | ESCC | 2.59e-16 | 3.59e-01 | 0.1276 |
7327 | UBE2G2 | P27T-E | Human | Esophagus | ESCC | 4.21e-25 | 6.11e-01 | 0.1055 |
7327 | UBE2G2 | P28T-E | Human | Esophagus | ESCC | 5.04e-31 | 6.18e-01 | 0.1149 |
7327 | UBE2G2 | P30T-E | Human | Esophagus | ESCC | 2.14e-27 | 8.59e-01 | 0.137 |
7327 | UBE2G2 | P31T-E | Human | Esophagus | ESCC | 1.45e-24 | 3.99e-01 | 0.1251 |
7327 | UBE2G2 | P32T-E | Human | Esophagus | ESCC | 5.54e-20 | 3.96e-01 | 0.1666 |
7327 | UBE2G2 | P36T-E | Human | Esophagus | ESCC | 3.27e-20 | 5.51e-01 | 0.1187 |
7327 | UBE2G2 | P37T-E | Human | Esophagus | ESCC | 2.45e-22 | 2.69e-01 | 0.1371 |
7327 | UBE2G2 | P38T-E | Human | Esophagus | ESCC | 3.69e-03 | 1.74e-01 | 0.127 |
7327 | UBE2G2 | P39T-E | Human | Esophagus | ESCC | 3.16e-18 | 2.15e-01 | 0.0894 |
7327 | UBE2G2 | P40T-E | Human | Esophagus | ESCC | 5.13e-14 | 2.98e-01 | 0.109 |
7327 | UBE2G2 | P42T-E | Human | Esophagus | ESCC | 5.21e-13 | 3.60e-01 | 0.1175 |
7327 | UBE2G2 | P44T-E | Human | Esophagus | ESCC | 1.26e-14 | 1.95e-01 | 0.1096 |
7327 | UBE2G2 | P47T-E | Human | Esophagus | ESCC | 3.33e-14 | 1.31e-01 | 0.1067 |
7327 | UBE2G2 | P48T-E | Human | Esophagus | ESCC | 8.19e-17 | 2.00e-01 | 0.0959 |
7327 | UBE2G2 | P49T-E | Human | Esophagus | ESCC | 3.74e-06 | 8.83e-01 | 0.1768 |
7327 | UBE2G2 | P52T-E | Human | Esophagus | ESCC | 4.87e-31 | 6.17e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:0033157110 | Esophagus | ESCC | regulation of intracellular protein transport | 169/8552 | 229/18723 | 3.31e-18 | 3.23e-16 | 169 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:003650315 | Esophagus | ESCC | ERAD pathway | 82/8552 | 107/18723 | 5.80e-11 | 1.84e-09 | 82 |
GO:007093617 | Esophagus | ESCC | protein K48-linked ubiquitination | 55/8552 | 65/18723 | 8.42e-11 | 2.58e-09 | 55 |
GO:003043314 | Esophagus | ESCC | ubiquitin-dependent ERAD pathway | 66/8552 | 85/18723 | 1.64e-09 | 3.78e-08 | 66 |
GO:003252714 | Esophagus | ESCC | protein exit from endoplasmic reticulum | 37/8552 | 48/18723 | 8.99e-06 | 8.65e-05 | 37 |
GO:19038289 | Esophagus | ESCC | negative regulation of cellular protein localization | 76/8552 | 117/18723 | 1.97e-05 | 1.72e-04 | 76 |
GO:003097014 | Esophagus | ESCC | retrograde protein transport, ER to cytosol | 23/8552 | 29/18723 | 2.25e-04 | 1.40e-03 | 23 |
GO:190351314 | Esophagus | ESCC | endoplasmic reticulum to cytosol transport | 23/8552 | 29/18723 | 2.25e-04 | 1.40e-03 | 23 |
GO:00512244 | Esophagus | ESCC | negative regulation of protein transport | 74/8552 | 127/18723 | 2.86e-03 | 1.21e-02 | 74 |
GO:19049505 | Esophagus | ESCC | negative regulation of establishment of protein localization | 76/8552 | 131/18723 | 2.96e-03 | 1.24e-02 | 76 |
GO:00323875 | Esophagus | ESCC | negative regulation of intracellular transport | 37/8552 | 58/18723 | 4.12e-03 | 1.64e-02 | 37 |
GO:00903174 | Esophagus | ESCC | negative regulation of intracellular protein transport | 28/8552 | 42/18723 | 4.90e-03 | 1.89e-02 | 28 |
GO:00708624 | Esophagus | ESCC | negative regulation of protein exit from endoplasmic reticulum | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:00708615 | Esophagus | ESCC | regulation of protein exit from endoplasmic reticulum | 19/8552 | 27/18723 | 8.35e-03 | 2.95e-02 | 19 |
GO:001049812 | Liver | Cirrhotic | proteasomal protein catabolic process | 216/4634 | 490/18723 | 2.52e-21 | 9.29e-19 | 216 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa05012211 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa05012310 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0412021 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0412031 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0501222 | Liver | HCC | Parkinson disease | 198/4020 | 266/8465 | 9.40e-20 | 1.58e-17 | 8.76e-18 | 198 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0501232 | Liver | HCC | Parkinson disease | 198/4020 | 266/8465 | 9.40e-20 | 1.58e-17 | 8.76e-18 | 198 |
hsa0412051 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa0501230 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE2G2 | SNV | Missense_Mutation | novel | c.235N>T | p.His79Tyr | p.H79Y | P60604 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A73U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
UBE2G2 | SNV | Missense_Mutation | rs782636745 | c.434N>A | p.Arg145His | p.R145H | P60604 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UBE2G2 | SNV | Missense_Mutation | rs782079899 | c.62N>T | p.Pro21Leu | p.P21L | P60604 | protein_coding | tolerated(0.3) | possibly_damaging(0.742) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBE2G2 | SNV | Missense_Mutation | c.236N>G | p.His79Arg | p.H79R | P60604 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6322-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | PD | |
UBE2G2 | SNV | Missense_Mutation | novel | c.412G>A | p.Val138Met | p.V138M | P60604 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE2G2 | SNV | Missense_Mutation | novel | c.260N>T | p.Arg87Ile | p.R87I | P60604 | protein_coding | deleterious(0.04) | benign(0.136) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
UBE2G2 | SNV | Missense_Mutation | novel | c.436N>A | p.Asp146Asn | p.D146N | P60604 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
UBE2G2 | SNV | Missense_Mutation | novel | c.128N>A | p.Gly43Asp | p.G43D | P60604 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
UBE2G2 | SNV | Missense_Mutation | novel | c.365N>G | p.Ser122Trp | p.S122W | P60604 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A3EW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
UBE2G2 | SNV | Missense_Mutation | novel | c.494N>C | p.Leu165Pro | p.L165P | P60604 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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