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Gene: TYW1 |
Gene summary for TYW1 |
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Gene information | Species | Human | Gene symbol | TYW1 | Gene ID | 55253 |
Gene name | tRNA-yW synthesizing protein 1 homolog | |
Gene Alias | RSAFD1 | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NV66 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55253 | TYW1 | A001-C-014 | Human | Colorectum | FAP | 3.02e-20 | -4.30e-01 | 0.0135 |
55253 | TYW1 | A002-C-016 | Human | Colorectum | FAP | 1.02e-21 | -4.15e-01 | 0.0521 |
55253 | TYW1 | A015-C-002 | Human | Colorectum | FAP | 8.04e-15 | -5.58e-01 | -0.0763 |
55253 | TYW1 | A001-C-203 | Human | Colorectum | FAP | 5.97e-11 | -2.77e-01 | -0.0481 |
55253 | TYW1 | A002-C-116 | Human | Colorectum | FAP | 2.78e-33 | -4.41e-01 | -0.0452 |
55253 | TYW1 | A014-C-008 | Human | Colorectum | FAP | 6.64e-14 | -4.02e-01 | -0.191 |
55253 | TYW1 | A018-E-020 | Human | Colorectum | FAP | 1.71e-20 | -3.93e-01 | -0.2034 |
55253 | TYW1 | F034 | Human | Colorectum | FAP | 1.66e-20 | -3.14e-01 | -0.0665 |
55253 | TYW1 | F072B | Human | Colorectum | FAP | 8.22e-07 | -2.69e-02 | 0.257 |
55253 | TYW1 | CRC-1-8810 | Human | Colorectum | CRC | 2.20e-02 | 6.25e-02 | 0.6257 |
55253 | TYW1 | CRC-3-11773 | Human | Colorectum | CRC | 9.82e-08 | -2.63e-01 | 0.2564 |
55253 | TYW1 | AEH-subject4 | Human | Endometrium | AEH | 3.50e-03 | 2.60e-01 | -0.2657 |
55253 | TYW1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.44e-04 | -7.31e-02 | -0.1916 |
55253 | TYW1 | LZE2T | Human | Esophagus | ESCC | 1.53e-12 | 6.29e-01 | 0.082 |
55253 | TYW1 | LZE4T | Human | Esophagus | ESCC | 7.44e-10 | 2.94e-01 | 0.0811 |
55253 | TYW1 | LZE7T | Human | Esophagus | ESCC | 7.15e-11 | 3.76e-01 | 0.0667 |
55253 | TYW1 | LZE8T | Human | Esophagus | ESCC | 3.62e-03 | 1.09e-01 | 0.067 |
55253 | TYW1 | LZE20T | Human | Esophagus | ESCC | 1.73e-05 | 1.41e-01 | 0.0662 |
55253 | TYW1 | LZE22T | Human | Esophagus | ESCC | 4.66e-03 | 4.17e-01 | 0.068 |
55253 | TYW1 | LZE24T | Human | Esophagus | ESCC | 2.01e-13 | 3.56e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00344707 | Endometrium | AEH | ncRNA processing | 62/2100 | 395/18723 | 3.93e-03 | 2.65e-02 | 62 |
GO:003447012 | Endometrium | EEC | ncRNA processing | 63/2168 | 395/18723 | 5.20e-03 | 3.26e-02 | 63 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:19016574 | Esophagus | ESCC | glycosyl compound metabolic process | 57/8552 | 88/18723 | 2.32e-04 | 1.44e-03 | 57 |
GO:00344704 | Liver | NAFLD | ncRNA processing | 57/1882 | 395/18723 | 3.34e-03 | 2.93e-02 | 57 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:19016572 | Liver | Cirrhotic | glycosyl compound metabolic process | 37/4634 | 88/18723 | 2.70e-04 | 2.40e-03 | 37 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
GO:19016571 | Liver | HCC | glycosyl compound metabolic process | 55/7958 | 88/18723 | 1.20e-04 | 1.01e-03 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TYW1 | SNV | Missense_Mutation | c.126N>G | p.Ile42Met | p.I42M | Q9NV66 | protein_coding | tolerated_low_confidence(0.2) | benign(0.001) | TCGA-AC-A2B8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD | |
TYW1 | SNV | Missense_Mutation | rs762930253 | c.1942G>A | p.Glu648Lys | p.E648K | Q9NV66 | protein_coding | tolerated(0.06) | benign(0.106) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TYW1 | SNV | Missense_Mutation | rs748628175 | c.308N>A | p.Ser103Tyr | p.S103Y | Q9NV66 | protein_coding | deleterious(0.01) | possibly_damaging(0.567) | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TYW1 | SNV | Missense_Mutation | c.2072N>G | p.Phe691Cys | p.F691C | Q9NV66 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AO-A0J8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
TYW1 | SNV | Missense_Mutation | c.1197C>A | p.Phe399Leu | p.F399L | Q9NV66 | protein_coding | deleterious(0.03) | benign(0.102) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TYW1 | SNV | Missense_Mutation | c.810G>T | p.Glu270Asp | p.E270D | Q9NV66 | protein_coding | tolerated(0.29) | benign(0.007) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TYW1 | SNV | Missense_Mutation | novel | c.1748A>G | p.Asp583Gly | p.D583G | Q9NV66 | protein_coding | deleterious(0) | benign(0.098) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TYW1 | SNV | Missense_Mutation | c.2032N>A | p.Leu678Ile | p.L678I | Q9NV66 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TYW1 | SNV | Missense_Mutation | c.217G>A | p.Asp73Asn | p.D73N | Q9NV66 | protein_coding | tolerated_low_confidence(0.2) | benign(0.014) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TYW1 | SNV | Missense_Mutation | c.47C>T | p.Ser16Leu | p.S16L | Q9NV66 | protein_coding | tolerated_low_confidence(0.25) | benign(0.006) | TCGA-AA-A02H-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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