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Gene: TXNL1 |
Gene summary for TXNL1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TXNL1 | Gene ID | 9352 |
Gene name | thioredoxin like 1 | |
Gene Alias | HEL-S-114 | |
Cytomap | 18q21.31 | |
Gene Type | protein-coding | GO ID | GO:0000502 | UniProtAcc | O43396 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9352 | TXNL1 | P21T-E | Human | Esophagus | ESCC | 8.18e-63 | 1.26e+00 | 0.1617 |
9352 | TXNL1 | P22T-E | Human | Esophagus | ESCC | 1.70e-48 | 8.62e-01 | 0.1236 |
9352 | TXNL1 | P23T-E | Human | Esophagus | ESCC | 8.12e-36 | 1.29e+00 | 0.108 |
9352 | TXNL1 | P24T-E | Human | Esophagus | ESCC | 1.19e-43 | 9.27e-01 | 0.1287 |
9352 | TXNL1 | P26T-E | Human | Esophagus | ESCC | 9.04e-104 | 2.01e+00 | 0.1276 |
9352 | TXNL1 | P27T-E | Human | Esophagus | ESCC | 4.82e-23 | 7.06e-01 | 0.1055 |
9352 | TXNL1 | P28T-E | Human | Esophagus | ESCC | 8.33e-19 | 5.44e-01 | 0.1149 |
9352 | TXNL1 | P30T-E | Human | Esophagus | ESCC | 2.91e-28 | 1.45e+00 | 0.137 |
9352 | TXNL1 | P31T-E | Human | Esophagus | ESCC | 2.43e-54 | 1.07e+00 | 0.1251 |
9352 | TXNL1 | P32T-E | Human | Esophagus | ESCC | 4.60e-52 | 1.23e+00 | 0.1666 |
9352 | TXNL1 | P36T-E | Human | Esophagus | ESCC | 2.18e-19 | 1.01e+00 | 0.1187 |
9352 | TXNL1 | P37T-E | Human | Esophagus | ESCC | 1.14e-26 | 9.43e-01 | 0.1371 |
9352 | TXNL1 | P38T-E | Human | Esophagus | ESCC | 2.35e-07 | 4.30e-01 | 0.127 |
9352 | TXNL1 | P39T-E | Human | Esophagus | ESCC | 2.40e-29 | 7.61e-01 | 0.0894 |
9352 | TXNL1 | P40T-E | Human | Esophagus | ESCC | 2.58e-12 | 5.94e-01 | 0.109 |
9352 | TXNL1 | P42T-E | Human | Esophagus | ESCC | 1.06e-10 | 5.82e-01 | 0.1175 |
9352 | TXNL1 | P44T-E | Human | Esophagus | ESCC | 7.53e-12 | 5.10e-01 | 0.1096 |
9352 | TXNL1 | P47T-E | Human | Esophagus | ESCC | 1.61e-21 | 4.52e-01 | 0.1067 |
9352 | TXNL1 | P48T-E | Human | Esophagus | ESCC | 5.44e-22 | 5.77e-01 | 0.0959 |
9352 | TXNL1 | P49T-E | Human | Esophagus | ESCC | 1.06e-18 | 2.33e+00 | 0.1768 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TXNL1 | SNV | Missense_Mutation | novel | c.484N>A | p.Asp162Asn | p.D162N | O43396 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AN-A0AM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TXNL1 | SNV | Missense_Mutation | c.659N>C | p.Leu220Pro | p.L220P | O43396 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TXNL1 | SNV | Missense_Mutation | c.585A>C | p.Lys195Asn | p.K195N | O43396 | protein_coding | deleterious(0) | possibly_damaging(0.814) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TXNL1 | SNV | Missense_Mutation | novel | c.93N>A | p.Met31Ile | p.M31I | O43396 | protein_coding | tolerated(0.05) | benign(0.001) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TXNL1 | SNV | Missense_Mutation | novel | c.839N>A | p.Arg280Gln | p.R280Q | O43396 | protein_coding | deleterious(0) | possibly_damaging(0.848) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TXNL1 | SNV | Missense_Mutation | c.585N>C | p.Lys195Asn | p.K195N | O43396 | protein_coding | deleterious(0) | possibly_damaging(0.814) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TXNL1 | SNV | Missense_Mutation | rs745346344 | c.479N>G | p.Asp160Gly | p.D160G | O43396 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TXNL1 | SNV | Missense_Mutation | c.700N>T | p.Arg234Cys | p.R234C | O43396 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TXNL1 | deletion | Frame_Shift_Del | novel | c.482delG | p.Cys161LeufsTer20 | p.C161Lfs*20 | O43396 | protein_coding | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
TXNL1 | deletion | Frame_Shift_Del | c.855delA | p.Gly286GlufsTer23 | p.G286Efs*23 | O43396 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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